Donor support for quality assurance and pharmacovigilance of anti-malarials in malaria-endemic countries
Abstract Background Malaria control efforts have been strengthened by funding from donor groups and government agencies. The Global Fund to Fight AIDS, Tuberculosis and the Malaria (Global Fund), the US President’s Malaria Initiative (PMI) account for the majority of donor support for malaria contro...
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ftdoajarticles:oai:doaj.org/article:e1ffadaee85145f2937791e68989d6e9 2023-05-15T15:17:15+02:00 Donor support for quality assurance and pharmacovigilance of anti-malarials in malaria-endemic countries Stephanie D. Kovacs Brianna M. Mills Andy Stergachis 2017-07-01T00:00:00Z https://doi.org/10.1186/s12936-017-1921-x https://doaj.org/article/e1ffadaee85145f2937791e68989d6e9 EN eng BMC http://link.springer.com/article/10.1186/s12936-017-1921-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1921-x 1475-2875 https://doaj.org/article/e1ffadaee85145f2937791e68989d6e9 Malaria Journal, Vol 16, Iss 1, Pp 1-10 (2017) Malaria Pharmacovigilance Adverse events Health system strengthening Artemisinin-based combination therapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2017 ftdoajarticles https://doi.org/10.1186/s12936-017-1921-x 2022-12-31T16:20:35Z Abstract Background Malaria control efforts have been strengthened by funding from donor groups and government agencies. The Global Fund to Fight AIDS, Tuberculosis and the Malaria (Global Fund), the US President’s Malaria Initiative (PMI) account for the majority of donor support for malaria control and prevention efforts. Pharmacovigilance (PV), which encompasses all activities relating to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problem, is a necessary part of efforts to reduce drug resistance and improve treatment outcomes. This paper reports on an analysis of PV plans in the Global Fund and PMI and World Bank’s grants for malaria prevention and control. Methods All active malaria grants as of September 2015 funded by the Global Fund and World Bank, and fiscal year 2015 and 2016 PMI Malaria Operational Plans (MOP) were identified. The total amount awarded for PV-related activities and drug quality assurance was abstracted. A Key-Word-in-Context (KWIC) analysis was conducted for the content of each grant. Specific search terms consisted of pharmacovigilance, pregn*, registry, safety, adverse drug, mass drug administration, primaquine, counterfeit, sub-standard, and falsified. Grants that mentioned PV activities identified in the KWIC search, listed PV in their budgets, or included the keywords: counterfeit, sub-standard, falsified, mass drug administration, or adverse event were thematically coded using Dedoose software version 7.0. Results The search identified 159 active malaria grants including 107 Global Fund grants, 39 fiscal year 2015 and 2016 PMI grants and 13 World Bank grants. These grants were primarily awarded to low-income countries (57.2%) and in sub-Saharan Africa (SSA) (70.4%). Thirty-seven (23.3%) grants included a budget line for PV- or drug quality assurance–related activities, including 21 PMI grants and 16 Global Fund grants. Only 23 (14.5%) grants directly mentioned PV. The primary focus area was improving drug quality ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 16 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Malaria Pharmacovigilance Adverse events Health system strengthening Artemisinin-based combination therapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Pharmacovigilance Adverse events Health system strengthening Artemisinin-based combination therapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Stephanie D. Kovacs Brianna M. Mills Andy Stergachis Donor support for quality assurance and pharmacovigilance of anti-malarials in malaria-endemic countries |
topic_facet |
Malaria Pharmacovigilance Adverse events Health system strengthening Artemisinin-based combination therapy Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria control efforts have been strengthened by funding from donor groups and government agencies. The Global Fund to Fight AIDS, Tuberculosis and the Malaria (Global Fund), the US President’s Malaria Initiative (PMI) account for the majority of donor support for malaria control and prevention efforts. Pharmacovigilance (PV), which encompasses all activities relating to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problem, is a necessary part of efforts to reduce drug resistance and improve treatment outcomes. This paper reports on an analysis of PV plans in the Global Fund and PMI and World Bank’s grants for malaria prevention and control. Methods All active malaria grants as of September 2015 funded by the Global Fund and World Bank, and fiscal year 2015 and 2016 PMI Malaria Operational Plans (MOP) were identified. The total amount awarded for PV-related activities and drug quality assurance was abstracted. A Key-Word-in-Context (KWIC) analysis was conducted for the content of each grant. Specific search terms consisted of pharmacovigilance, pregn*, registry, safety, adverse drug, mass drug administration, primaquine, counterfeit, sub-standard, and falsified. Grants that mentioned PV activities identified in the KWIC search, listed PV in their budgets, or included the keywords: counterfeit, sub-standard, falsified, mass drug administration, or adverse event were thematically coded using Dedoose software version 7.0. Results The search identified 159 active malaria grants including 107 Global Fund grants, 39 fiscal year 2015 and 2016 PMI grants and 13 World Bank grants. These grants were primarily awarded to low-income countries (57.2%) and in sub-Saharan Africa (SSA) (70.4%). Thirty-seven (23.3%) grants included a budget line for PV- or drug quality assurance–related activities, including 21 PMI grants and 16 Global Fund grants. Only 23 (14.5%) grants directly mentioned PV. The primary focus area was improving drug quality ... |
format |
Article in Journal/Newspaper |
author |
Stephanie D. Kovacs Brianna M. Mills Andy Stergachis |
author_facet |
Stephanie D. Kovacs Brianna M. Mills Andy Stergachis |
author_sort |
Stephanie D. Kovacs |
title |
Donor support for quality assurance and pharmacovigilance of anti-malarials in malaria-endemic countries |
title_short |
Donor support for quality assurance and pharmacovigilance of anti-malarials in malaria-endemic countries |
title_full |
Donor support for quality assurance and pharmacovigilance of anti-malarials in malaria-endemic countries |
title_fullStr |
Donor support for quality assurance and pharmacovigilance of anti-malarials in malaria-endemic countries |
title_full_unstemmed |
Donor support for quality assurance and pharmacovigilance of anti-malarials in malaria-endemic countries |
title_sort |
donor support for quality assurance and pharmacovigilance of anti-malarials in malaria-endemic countries |
publisher |
BMC |
publishDate |
2017 |
url |
https://doi.org/10.1186/s12936-017-1921-x https://doaj.org/article/e1ffadaee85145f2937791e68989d6e9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 16, Iss 1, Pp 1-10 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s12936-017-1921-x https://doaj.org/toc/1475-2875 doi:10.1186/s12936-017-1921-x 1475-2875 https://doaj.org/article/e1ffadaee85145f2937791e68989d6e9 |
op_doi |
https://doi.org/10.1186/s12936-017-1921-x |
container_title |
Malaria Journal |
container_volume |
16 |
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1 |
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1766347508610498560 |