Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting
Abstract Background Therapeutic ineffectiveness of artemisinin-based combination therapy (ACT) increases the risk of malaria-related morbidity and mortality, and raises healthcare costs. Yet, little has been done to promote the pharmacovigilance (PV) of ACT ineffectiveness in sub-Saharan Africa, par...
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ftdoajarticles:oai:doaj.org/article:e1e5422de5a84c6e86317e51291c2fc0 2023-05-15T15:16:12+02:00 Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting Ronald Kiguba Helen Byomire Ndagije Victoria Nambasa Leonard Manirakiza Elijah Kirabira Allan Serwanga Sten Olsson Niko Speybroeck Jackson Mukonzo 2020-11-01T00:00:00Z https://doi.org/10.1186/s12936-020-03463-7 https://doaj.org/article/e1e5422de5a84c6e86317e51291c2fc0 EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03463-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03463-7 1475-2875 https://doaj.org/article/e1e5422de5a84c6e86317e51291c2fc0 Malaria Journal, Vol 19, Iss 1, Pp 1-10 (2020) Artemisinin-based combination therapy Therapeutic inefficacy Therapeutic ineffectiveness Therapeutic efficacy Therapeutic effectiveness Pharmacovigilance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03463-7 2022-12-31T03:24:05Z Abstract Background Therapeutic ineffectiveness of artemisinin-based combination therapy (ACT) increases the risk of malaria-related morbidity and mortality, and raises healthcare costs. Yet, little has been done to promote the pharmacovigilance (PV) of ACT ineffectiveness in sub-Saharan Africa, particularly in Uganda. This study aimed to determine the extent and associated factors of the past 6 months reporting of suspected or confirmed ACT therapeutic ineffectiveness by healthcare professionals (HCPs), and difficulties and potential solutions to the PV of ACT therapeutic ineffectiveness. Methods Survey of 685 HCPs conducted using a self-administered questionnaire from June to July 2018 in a nationally representative sample of public and private health facilities in Uganda. HCPs disclosed if they had spontaneously reported ACT therapeutic ineffectiveness to appropriate authorities in the previous 6 months. Multivariable logistic regression models were used to identify determinants of past 6-months, HCP-reported ACT therapeutic ineffectiveness. Results One in five (20%, 137/685; 95% CI 17–23%) HCPs reported ACT therapeutic ineffectiveness to an appropriate authority in the previous 6 months. HCPs commonly reported ACT therapeutic ineffectiveness to immediate supervisors (72%, 106/147), mostly verbally only (80%, 109/137); none had ever submitted a written report of ACT therapeutic ineffectiveness to Uganda’s National Pharmacovigilance Centre. Common difficulties of reporting ACT therapeutic ineffectiveness were: unavailability of reporting procedures (31%, 129/421), poor follow-up of treated patients (22%, 93/421) and absence of reporting tools (16%, 68/421). Factors associated with reporting ACT therapeutic ineffectiveness in the past 6 months were: hospital-status (vs other; OR = 2.4, 95% CI 1.41–4.21), HCPs aged under 25 years (OR = 2.2, 95% CI 1.29–3.76), suspicion of ACT therapeutic ineffectiveness in the past 4 weeks (OR = 2.3, 95% CI 1.29–3.92), receipt of patient-complaint(s) of ACT therapeutic ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Artemisinin-based combination therapy Therapeutic inefficacy Therapeutic ineffectiveness Therapeutic efficacy Therapeutic effectiveness Pharmacovigilance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Artemisinin-based combination therapy Therapeutic inefficacy Therapeutic ineffectiveness Therapeutic efficacy Therapeutic effectiveness Pharmacovigilance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ronald Kiguba Helen Byomire Ndagije Victoria Nambasa Leonard Manirakiza Elijah Kirabira Allan Serwanga Sten Olsson Niko Speybroeck Jackson Mukonzo Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting |
topic_facet |
Artemisinin-based combination therapy Therapeutic inefficacy Therapeutic ineffectiveness Therapeutic efficacy Therapeutic effectiveness Pharmacovigilance Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Therapeutic ineffectiveness of artemisinin-based combination therapy (ACT) increases the risk of malaria-related morbidity and mortality, and raises healthcare costs. Yet, little has been done to promote the pharmacovigilance (PV) of ACT ineffectiveness in sub-Saharan Africa, particularly in Uganda. This study aimed to determine the extent and associated factors of the past 6 months reporting of suspected or confirmed ACT therapeutic ineffectiveness by healthcare professionals (HCPs), and difficulties and potential solutions to the PV of ACT therapeutic ineffectiveness. Methods Survey of 685 HCPs conducted using a self-administered questionnaire from June to July 2018 in a nationally representative sample of public and private health facilities in Uganda. HCPs disclosed if they had spontaneously reported ACT therapeutic ineffectiveness to appropriate authorities in the previous 6 months. Multivariable logistic regression models were used to identify determinants of past 6-months, HCP-reported ACT therapeutic ineffectiveness. Results One in five (20%, 137/685; 95% CI 17–23%) HCPs reported ACT therapeutic ineffectiveness to an appropriate authority in the previous 6 months. HCPs commonly reported ACT therapeutic ineffectiveness to immediate supervisors (72%, 106/147), mostly verbally only (80%, 109/137); none had ever submitted a written report of ACT therapeutic ineffectiveness to Uganda’s National Pharmacovigilance Centre. Common difficulties of reporting ACT therapeutic ineffectiveness were: unavailability of reporting procedures (31%, 129/421), poor follow-up of treated patients (22%, 93/421) and absence of reporting tools (16%, 68/421). Factors associated with reporting ACT therapeutic ineffectiveness in the past 6 months were: hospital-status (vs other; OR = 2.4, 95% CI 1.41–4.21), HCPs aged under 25 years (OR = 2.2, 95% CI 1.29–3.76), suspicion of ACT therapeutic ineffectiveness in the past 4 weeks (OR = 2.3, 95% CI 1.29–3.92), receipt of patient-complaint(s) of ACT therapeutic ... |
format |
Article in Journal/Newspaper |
author |
Ronald Kiguba Helen Byomire Ndagije Victoria Nambasa Leonard Manirakiza Elijah Kirabira Allan Serwanga Sten Olsson Niko Speybroeck Jackson Mukonzo |
author_facet |
Ronald Kiguba Helen Byomire Ndagije Victoria Nambasa Leonard Manirakiza Elijah Kirabira Allan Serwanga Sten Olsson Niko Speybroeck Jackson Mukonzo |
author_sort |
Ronald Kiguba |
title |
Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting |
title_short |
Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting |
title_full |
Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting |
title_fullStr |
Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting |
title_full_unstemmed |
Pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting |
title_sort |
pharmacovigilance of suspected or confirmed therapeutic ineffectiveness of artemisinin-based combination therapy: extent, associated factors, challenges and solutions to reporting |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03463-7 https://doaj.org/article/e1e5422de5a84c6e86317e51291c2fc0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-10 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03463-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03463-7 1475-2875 https://doaj.org/article/e1e5422de5a84c6e86317e51291c2fc0 |
op_doi |
https://doi.org/10.1186/s12936-020-03463-7 |
container_title |
Malaria Journal |
container_volume |
19 |
container_issue |
1 |
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1766346495935643648 |