Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response.
Mayaro virus (MAYV), an alphavirus similar to chikungunya virus (CHIKV), causes an acute debilitating disease which results in the development of long-term arthralgia in more than 50% of infected individuals. Currently, the immune response and its role in the development of MAYV-induced persistent a...
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ftdoajarticles:oai:doaj.org/article:e1db52caad0747d7a3ffa45014823f22 2023-05-15T15:06:41+02:00 Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. Felix W Santiago Eric S Halsey Crystyan Siles Stalin Vilcarromero Carolina Guevara Jesus A Silvas Cesar Ramal Julia S Ampuero Patricia V Aguilar 2015-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004104 https://doaj.org/article/e1db52caad0747d7a3ffa45014823f22 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4619727?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004104 https://doaj.org/article/e1db52caad0747d7a3ffa45014823f22 PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004104 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004104 2022-12-31T08:17:05Z Mayaro virus (MAYV), an alphavirus similar to chikungunya virus (CHIKV), causes an acute debilitating disease which results in the development of long-term arthralgia in more than 50% of infected individuals. Currently, the immune response and its role in the development of MAYV-induced persistent arthralgia remain unknown. In this study, we evaluated the immune response of individuals with confirmed MAYV infection in a one-year longitudinal study carried out in Loreto, Peru. We report that MAYV infection elicits robust immune responses that result in the development of a strong neutralizing antibody response and the secretion of pro-inflammatory immune mediators. The composition of these inflammatory mediators, in some cases, differed to those previously observed for CHIKV. Key mediators such as IL-13, IL-7 and VEGF were strongly induced following MAYV infection and were significantly increased in subjects that eventually developed persistent arthralgia. Although a strong neutralizing antibody response was observed in all subjects, it was not sufficient to prevent the long-term outcomes of MAYV infection. This study provides initial immunologic insight that may eventually contribute to prognostic tools and therapeutic treatments against this emerging pathogen. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 10 e0004104 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Felix W Santiago Eric S Halsey Crystyan Siles Stalin Vilcarromero Carolina Guevara Jesus A Silvas Cesar Ramal Julia S Ampuero Patricia V Aguilar Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Mayaro virus (MAYV), an alphavirus similar to chikungunya virus (CHIKV), causes an acute debilitating disease which results in the development of long-term arthralgia in more than 50% of infected individuals. Currently, the immune response and its role in the development of MAYV-induced persistent arthralgia remain unknown. In this study, we evaluated the immune response of individuals with confirmed MAYV infection in a one-year longitudinal study carried out in Loreto, Peru. We report that MAYV infection elicits robust immune responses that result in the development of a strong neutralizing antibody response and the secretion of pro-inflammatory immune mediators. The composition of these inflammatory mediators, in some cases, differed to those previously observed for CHIKV. Key mediators such as IL-13, IL-7 and VEGF were strongly induced following MAYV infection and were significantly increased in subjects that eventually developed persistent arthralgia. Although a strong neutralizing antibody response was observed in all subjects, it was not sufficient to prevent the long-term outcomes of MAYV infection. This study provides initial immunologic insight that may eventually contribute to prognostic tools and therapeutic treatments against this emerging pathogen. |
format |
Article in Journal/Newspaper |
author |
Felix W Santiago Eric S Halsey Crystyan Siles Stalin Vilcarromero Carolina Guevara Jesus A Silvas Cesar Ramal Julia S Ampuero Patricia V Aguilar |
author_facet |
Felix W Santiago Eric S Halsey Crystyan Siles Stalin Vilcarromero Carolina Guevara Jesus A Silvas Cesar Ramal Julia S Ampuero Patricia V Aguilar |
author_sort |
Felix W Santiago |
title |
Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. |
title_short |
Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. |
title_full |
Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. |
title_fullStr |
Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. |
title_full_unstemmed |
Long-Term Arthralgia after Mayaro Virus Infection Correlates with Sustained Pro-inflammatory Cytokine Response. |
title_sort |
long-term arthralgia after mayaro virus infection correlates with sustained pro-inflammatory cytokine response. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0004104 https://doaj.org/article/e1db52caad0747d7a3ffa45014823f22 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004104 (2015) |
op_relation |
http://europepmc.org/articles/PMC4619727?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004104 https://doaj.org/article/e1db52caad0747d7a3ffa45014823f22 |
op_doi |
https://doi.org/10.1371/journal.pntd.0004104 |
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PLOS Neglected Tropical Diseases |
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9 |
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10 |
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e0004104 |
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