Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa.
Accurate data on the Lassa virus (LASV) human case fatality rate (CFR) and the prevalence of LASV in humans, rodents and other mammals are needed for better planning of actions that will ultimately reduce the burden of LASV infection in sub-Saharan Africa. In this systematic review with meta-analysi...
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ftdoajarticles:oai:doaj.org/article:e1d52dff141546e79b086247a6516c87 2023-05-15T15:15:32+02:00 Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa. Sebastien Kenmoe Serges Tchatchouang Jean Thierry Ebogo-Belobo Aude Christelle Ka'e Gadji Mahamat Raïssa Estelle Guiamdjo Simo Arnol Bowo-Ngandji Cynthia Paola Demeni Emoh Emmanuel Che Dimitri Tchami Ngongang Marie Amougou-Atsama Nathalie Diane Nzukui Chris Andre Mbongue Mikangue Donatien Serge Mbaga Sorel Kenfack Sandrine Rachel Kingue Bebey Nathalie Amvongo Adjia Atembeh Noura Efietngab Hervé Raoul Tazokong Abdou Fatawou Modiyinji Cyprien Kengne-Nde Serge Alain Sadeuh-Mba Richard Njouom 2020-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008589 https://doaj.org/article/e1d52dff141546e79b086247a6516c87 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008589 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008589 https://doaj.org/article/e1d52dff141546e79b086247a6516c87 PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008589 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008589 2022-12-31T07:51:08Z Accurate data on the Lassa virus (LASV) human case fatality rate (CFR) and the prevalence of LASV in humans, rodents and other mammals are needed for better planning of actions that will ultimately reduce the burden of LASV infection in sub-Saharan Africa. In this systematic review with meta-analysis, we searched PubMed, Scopus, Africa Journal Online, and African Index Medicus from 1969 to 2020 to obtain studies that reported enough data to calculate LASV infection CFR or prevalence. Study selection, data extraction, and risk of bias assessment were conducted independently. We extracted all measures of current, recent, and past infections with LASV. Prevalence and CFR estimates were pooled using a random-effect meta-analysis. Factors associated with CFR, prevalence, and sources of between-study heterogeneity were determined using subgroup and metaregression analyses. This review was registered with PROSPERO, CRD42020166465. We initially identified 1,399 records and finally retained 109 reports that contributed to 291 prevalence records from 25 countries. The overall CFR was 29.7% (22.3-37.5) in humans. Pooled prevalence of LASV infection was 8.7% (95% confidence interval: 6.8-10.8) in humans, 3.2% (1.9-4.6) in rodents, and 0.7% (0.0-2.3) in other mammals. Subgroup and metaregression analyses revealed a substantial statistical heterogeneity explained by higher prevalence in tissue organs, in case-control, in hospital outbreak, and surveys, in retrospective studies, in urban and hospital setting, in hospitalized patients, and in West African countries. This study suggests that LASV infections is an important cause of death in humans and that LASV are common in humans, rodents and other mammals in sub-Saharan Africa. These estimates highlight disparities between sub-regions, and population risk profiles. Western Africa, and specific key populations were identified as having higher LASV CFR and prevalence, hence, deserving more attention for cost-effective preventive interventions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 8 e0008589 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Sebastien Kenmoe Serges Tchatchouang Jean Thierry Ebogo-Belobo Aude Christelle Ka'e Gadji Mahamat Raïssa Estelle Guiamdjo Simo Arnol Bowo-Ngandji Cynthia Paola Demeni Emoh Emmanuel Che Dimitri Tchami Ngongang Marie Amougou-Atsama Nathalie Diane Nzukui Chris Andre Mbongue Mikangue Donatien Serge Mbaga Sorel Kenfack Sandrine Rachel Kingue Bebey Nathalie Amvongo Adjia Atembeh Noura Efietngab Hervé Raoul Tazokong Abdou Fatawou Modiyinji Cyprien Kengne-Nde Serge Alain Sadeuh-Mba Richard Njouom Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Accurate data on the Lassa virus (LASV) human case fatality rate (CFR) and the prevalence of LASV in humans, rodents and other mammals are needed for better planning of actions that will ultimately reduce the burden of LASV infection in sub-Saharan Africa. In this systematic review with meta-analysis, we searched PubMed, Scopus, Africa Journal Online, and African Index Medicus from 1969 to 2020 to obtain studies that reported enough data to calculate LASV infection CFR or prevalence. Study selection, data extraction, and risk of bias assessment were conducted independently. We extracted all measures of current, recent, and past infections with LASV. Prevalence and CFR estimates were pooled using a random-effect meta-analysis. Factors associated with CFR, prevalence, and sources of between-study heterogeneity were determined using subgroup and metaregression analyses. This review was registered with PROSPERO, CRD42020166465. We initially identified 1,399 records and finally retained 109 reports that contributed to 291 prevalence records from 25 countries. The overall CFR was 29.7% (22.3-37.5) in humans. Pooled prevalence of LASV infection was 8.7% (95% confidence interval: 6.8-10.8) in humans, 3.2% (1.9-4.6) in rodents, and 0.7% (0.0-2.3) in other mammals. Subgroup and metaregression analyses revealed a substantial statistical heterogeneity explained by higher prevalence in tissue organs, in case-control, in hospital outbreak, and surveys, in retrospective studies, in urban and hospital setting, in hospitalized patients, and in West African countries. This study suggests that LASV infections is an important cause of death in humans and that LASV are common in humans, rodents and other mammals in sub-Saharan Africa. These estimates highlight disparities between sub-regions, and population risk profiles. Western Africa, and specific key populations were identified as having higher LASV CFR and prevalence, hence, deserving more attention for cost-effective preventive interventions. |
format |
Article in Journal/Newspaper |
author |
Sebastien Kenmoe Serges Tchatchouang Jean Thierry Ebogo-Belobo Aude Christelle Ka'e Gadji Mahamat Raïssa Estelle Guiamdjo Simo Arnol Bowo-Ngandji Cynthia Paola Demeni Emoh Emmanuel Che Dimitri Tchami Ngongang Marie Amougou-Atsama Nathalie Diane Nzukui Chris Andre Mbongue Mikangue Donatien Serge Mbaga Sorel Kenfack Sandrine Rachel Kingue Bebey Nathalie Amvongo Adjia Atembeh Noura Efietngab Hervé Raoul Tazokong Abdou Fatawou Modiyinji Cyprien Kengne-Nde Serge Alain Sadeuh-Mba Richard Njouom |
author_facet |
Sebastien Kenmoe Serges Tchatchouang Jean Thierry Ebogo-Belobo Aude Christelle Ka'e Gadji Mahamat Raïssa Estelle Guiamdjo Simo Arnol Bowo-Ngandji Cynthia Paola Demeni Emoh Emmanuel Che Dimitri Tchami Ngongang Marie Amougou-Atsama Nathalie Diane Nzukui Chris Andre Mbongue Mikangue Donatien Serge Mbaga Sorel Kenfack Sandrine Rachel Kingue Bebey Nathalie Amvongo Adjia Atembeh Noura Efietngab Hervé Raoul Tazokong Abdou Fatawou Modiyinji Cyprien Kengne-Nde Serge Alain Sadeuh-Mba Richard Njouom |
author_sort |
Sebastien Kenmoe |
title |
Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa. |
title_short |
Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa. |
title_full |
Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa. |
title_fullStr |
Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa. |
title_full_unstemmed |
Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa. |
title_sort |
systematic review and meta-analysis of the epidemiology of lassa virus in humans, rodents and other mammals in sub-saharan africa. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008589 https://doaj.org/article/e1d52dff141546e79b086247a6516c87 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008589 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008589 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008589 https://doaj.org/article/e1d52dff141546e79b086247a6516c87 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008589 |
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PLOS Neglected Tropical Diseases |
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e0008589 |
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