Reduction of morbidity in hepatosplenic Schistosomiasis mansoni after treatment with praziquantel: a long term study
Forty-two with hepatosplenic patients treated with praziquantel and followed up for 5 years. One half of the patients received a single 30 mg/kg dose and the other half, two doses of 25 mg/kg given 4 hrs apart. According to Hoffman and Kato-Katz stool exams, an 83.3% cure rate, was observed after tw...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1990
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ftdoajarticles:oai:doaj.org/article:e1b23d16e23b4541a4d2a55f4abac69f 2023-05-15T15:04:04+02:00 Reduction of morbidity in hepatosplenic Schistosomiasis mansoni after treatment with praziquantel: a long term study Ana Lúcia C. Domingues Amaury D. Coutinho 1990-06-01T00:00:00Z https://doi.org/10.1590/S0037-86821990000200007 https://doaj.org/article/e1b23d16e23b4541a4d2a55f4abac69f EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821990000200007&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821990000200007 https://doaj.org/article/e1b23d16e23b4541a4d2a55f4abac69f Revista da Sociedade Brasileira de Medicina Tropical, Vol 23, Iss 2, Pp 101-107 (1990) Esquistossomose mansoni hepatosplênica Tratamento Reversão Arctic medicine. Tropical medicine RC955-962 article 1990 ftdoajarticles https://doi.org/10.1590/S0037-86821990000200007 2022-12-31T02:14:24Z Forty-two with hepatosplenic patients treated with praziquantel and followed up for 5 years. One half of the patients received a single 30 mg/kg dose and the other half, two doses of 25 mg/kg given 4 hrs apart. According to Hoffman and Kato-Katz stool exams, an 83.3% cure rate, was observed after twelve months. Stool egg counts in cases of incomplete cure were greatly reduced. Liver function, as assessed by serum levels of aspartate aminotransferase, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase activities as well as albumin and gamma globulin showed marked improvement after one year. Hepatomegaly was reduced in 81.0% of patients and splenomegaly in 78.8%. Spleen regression was complete in 15.1% of the total, and in 18.5% of those with compensated hepatosplenic disease. As a result of these observations, the authors recomend early treatment with anti-schistosomal medication, either oxamniquine or praziquantel, to halt progression of disease and reduce splenomegaly. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 23 2 101 107 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
topic |
Esquistossomose mansoni hepatosplênica Tratamento Reversão Arctic medicine. Tropical medicine RC955-962 |
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Esquistossomose mansoni hepatosplênica Tratamento Reversão Arctic medicine. Tropical medicine RC955-962 Ana Lúcia C. Domingues Amaury D. Coutinho Reduction of morbidity in hepatosplenic Schistosomiasis mansoni after treatment with praziquantel: a long term study |
topic_facet |
Esquistossomose mansoni hepatosplênica Tratamento Reversão Arctic medicine. Tropical medicine RC955-962 |
description |
Forty-two with hepatosplenic patients treated with praziquantel and followed up for 5 years. One half of the patients received a single 30 mg/kg dose and the other half, two doses of 25 mg/kg given 4 hrs apart. According to Hoffman and Kato-Katz stool exams, an 83.3% cure rate, was observed after twelve months. Stool egg counts in cases of incomplete cure were greatly reduced. Liver function, as assessed by serum levels of aspartate aminotransferase, alanine aminotransferase, gamma glutamyltransferase and alkaline phosphatase activities as well as albumin and gamma globulin showed marked improvement after one year. Hepatomegaly was reduced in 81.0% of patients and splenomegaly in 78.8%. Spleen regression was complete in 15.1% of the total, and in 18.5% of those with compensated hepatosplenic disease. As a result of these observations, the authors recomend early treatment with anti-schistosomal medication, either oxamniquine or praziquantel, to halt progression of disease and reduce splenomegaly. |
format |
Article in Journal/Newspaper |
author |
Ana Lúcia C. Domingues Amaury D. Coutinho |
author_facet |
Ana Lúcia C. Domingues Amaury D. Coutinho |
author_sort |
Ana Lúcia C. Domingues |
title |
Reduction of morbidity in hepatosplenic Schistosomiasis mansoni after treatment with praziquantel: a long term study |
title_short |
Reduction of morbidity in hepatosplenic Schistosomiasis mansoni after treatment with praziquantel: a long term study |
title_full |
Reduction of morbidity in hepatosplenic Schistosomiasis mansoni after treatment with praziquantel: a long term study |
title_fullStr |
Reduction of morbidity in hepatosplenic Schistosomiasis mansoni after treatment with praziquantel: a long term study |
title_full_unstemmed |
Reduction of morbidity in hepatosplenic Schistosomiasis mansoni after treatment with praziquantel: a long term study |
title_sort |
reduction of morbidity in hepatosplenic schistosomiasis mansoni after treatment with praziquantel: a long term study |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1990 |
url |
https://doi.org/10.1590/S0037-86821990000200007 https://doaj.org/article/e1b23d16e23b4541a4d2a55f4abac69f |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 23, Iss 2, Pp 101-107 (1990) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821990000200007&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821990000200007 https://doaj.org/article/e1b23d16e23b4541a4d2a55f4abac69f |
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https://doi.org/10.1590/S0037-86821990000200007 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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23 |
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