Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma.
Eumycetoma is a traumatic fungal infection in tropical and subtropical areas that may lead to severe disability. Madurella mycetomatis is one of the prevalent etiologic agents in arid Northeastern Africa. The source of infection has not been clarified. Subcutaneous inoculation from plant thorns has...
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ftdoajarticles:oai:doaj.org/article:e179eb9628624921a3a5af1e3fab0b82 2023-05-15T15:08:15+02:00 Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. G Sybren de Hoog Sarah A Ahmed Mohammad J Najafzadeh Deanna A Sutton Maryam Saradeghi Keisari Ahmed H Fahal Ursala Eberhardt Gerard J Verkleij Lian Xin Benjamin Stielow Wendy W J van de Sande 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002229 https://doaj.org/article/e179eb9628624921a3a5af1e3fab0b82 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3656121?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0002229 https://doaj.org/article/e179eb9628624921a3a5af1e3fab0b82 PLoS Neglected Tropical Diseases, Vol 7, Iss 5, p e2229 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002229 2022-12-30T21:52:22Z Eumycetoma is a traumatic fungal infection in tropical and subtropical areas that may lead to severe disability. Madurella mycetomatis is one of the prevalent etiologic agents in arid Northeastern Africa. The source of infection has not been clarified. Subcutaneous inoculation from plant thorns has been hypothesized, but attempts to detect the fungus in relevant material have remained unsuccessful. The present study aims to find clues to reveal the natural habitat of Madurella species using a phylogenetic approach, i.e. by comparison of neighboring taxa with known ecology. Four species of Madurella were included in a large data set of species of Chaetomium, Chaetomidium, Thielavia, and Papulaspora (n = 128) using sequences of the universal fungal barcode gene rDNA ITS and the partial LSU gene sequence. Our study demonstrates that Madurella species are nested within the Chaetomiaceae, a family of fungi that mainly inhabit animal dung, enriched soil, and indoor environments. We hypothesize that cattle dung, ubiquitously present in rural East Africa, plays a significant role in the ecology of Madurella. If cow dung is an essential factor in inoculation by Madurella, preventative measures may involve the use of appropriate footwear in addition to restructuring of villages to reduce the frequency of contact with etiologic agents of mycetoma. On the other hand, the Chaetomiaceae possess a hidden clinical potential which needs to be explored. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 5 e2229 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 G Sybren de Hoog Sarah A Ahmed Mohammad J Najafzadeh Deanna A Sutton Maryam Saradeghi Keisari Ahmed H Fahal Ursala Eberhardt Gerard J Verkleij Lian Xin Benjamin Stielow Wendy W J van de Sande Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Eumycetoma is a traumatic fungal infection in tropical and subtropical areas that may lead to severe disability. Madurella mycetomatis is one of the prevalent etiologic agents in arid Northeastern Africa. The source of infection has not been clarified. Subcutaneous inoculation from plant thorns has been hypothesized, but attempts to detect the fungus in relevant material have remained unsuccessful. The present study aims to find clues to reveal the natural habitat of Madurella species using a phylogenetic approach, i.e. by comparison of neighboring taxa with known ecology. Four species of Madurella were included in a large data set of species of Chaetomium, Chaetomidium, Thielavia, and Papulaspora (n = 128) using sequences of the universal fungal barcode gene rDNA ITS and the partial LSU gene sequence. Our study demonstrates that Madurella species are nested within the Chaetomiaceae, a family of fungi that mainly inhabit animal dung, enriched soil, and indoor environments. We hypothesize that cattle dung, ubiquitously present in rural East Africa, plays a significant role in the ecology of Madurella. If cow dung is an essential factor in inoculation by Madurella, preventative measures may involve the use of appropriate footwear in addition to restructuring of villages to reduce the frequency of contact with etiologic agents of mycetoma. On the other hand, the Chaetomiaceae possess a hidden clinical potential which needs to be explored. |
format |
Article in Journal/Newspaper |
author |
G Sybren de Hoog Sarah A Ahmed Mohammad J Najafzadeh Deanna A Sutton Maryam Saradeghi Keisari Ahmed H Fahal Ursala Eberhardt Gerard J Verkleij Lian Xin Benjamin Stielow Wendy W J van de Sande |
author_facet |
G Sybren de Hoog Sarah A Ahmed Mohammad J Najafzadeh Deanna A Sutton Maryam Saradeghi Keisari Ahmed H Fahal Ursala Eberhardt Gerard J Verkleij Lian Xin Benjamin Stielow Wendy W J van de Sande |
author_sort |
G Sybren de Hoog |
title |
Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. |
title_short |
Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. |
title_full |
Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. |
title_fullStr |
Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. |
title_full_unstemmed |
Phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. |
title_sort |
phylogenetic findings suggest possible new habitat and routes of infection of human eumyctoma. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002229 https://doaj.org/article/e179eb9628624921a3a5af1e3fab0b82 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 5, p e2229 (2013) |
op_relation |
http://europepmc.org/articles/PMC3656121?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0002229 https://doaj.org/article/e179eb9628624921a3a5af1e3fab0b82 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002229 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
7 |
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5 |
container_start_page |
e2229 |
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1766339647770722304 |