Effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with Trypanosoma cruzi
Adult mice were submitted to different degrees of protein restriction for five weeks (4.75, 9.5,14.25 and 19% of protein in isocaloric diets with normal content of mineral and vitamins), being subsequently infected with two strains of Trypanosoma cruzi: 10(5) trypomastigotes of Y strain or 14(5) try...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1994
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Online Access: | https://doi.org/10.1590/S0037-86821994000100005 https://doaj.org/article/e160bdb7a21f4ab993591974188c1954 |
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ftdoajarticles:oai:doaj.org/article:e160bdb7a21f4ab993591974188c1954 2023-05-15T15:05:01+02:00 Effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with Trypanosoma cruzi Nildete G.L. Gomes Fausto E.L. Pereira Gisele G.S. Domingues Jesse R. Alves 1994-03-01T00:00:00Z https://doi.org/10.1590/S0037-86821994000100005 https://doaj.org/article/e160bdb7a21f4ab993591974188c1954 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821994000100005&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821994000100005 https://doaj.org/article/e160bdb7a21f4ab993591974188c1954 Revista da Sociedade Brasileira de Medicina Tropical, Vol 27, Iss 1, Pp 19-24 (1994) Desnutrição Doença de Chagas Trypanosoma cruzi Arctic medicine. Tropical medicine RC955-962 article 1994 ftdoajarticles https://doi.org/10.1590/S0037-86821994000100005 2022-12-30T21:26:03Z Adult mice were submitted to different degrees of protein restriction for five weeks (4.75, 9.5,14.25 and 19% of protein in isocaloric diets with normal content of mineral and vitamins), being subsequently infected with two strains of Trypanosoma cruzi: 10(5) trypomastigotes of Y strain or 14(5) trypomastigotes of CL strain. The same diet was maintained for all animals and the infection wasfollowed up by evaluation of blood parasites, mortality and intensity of lesions in the heart and skeleton muscle. Only severe protein restriction (4.75%) induced decrease in resistance to the infection with both the Y and CL strains of T. cruzi, which resulted in higher parasitemia and mortality. The inflammatory lesions in heart and skeleton muscle were less extensive in groups with severe protein restriction despite the increased number of parasite in muscle cells. Depression of immune mechanisms could be responsiblefor the reduced resistance and reduced inflammatory reaction after T. cruzi infection in severely protein restricted animals. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic The ''Y'' ENVELOPE(-112.453,-112.453,57.591,57.591) Revista da Sociedade Brasileira de Medicina Tropical 27 1 19 24 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Desnutrição Doença de Chagas Trypanosoma cruzi Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Desnutrição Doença de Chagas Trypanosoma cruzi Arctic medicine. Tropical medicine RC955-962 Nildete G.L. Gomes Fausto E.L. Pereira Gisele G.S. Domingues Jesse R. Alves Effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with Trypanosoma cruzi |
topic_facet |
Desnutrição Doença de Chagas Trypanosoma cruzi Arctic medicine. Tropical medicine RC955-962 |
description |
Adult mice were submitted to different degrees of protein restriction for five weeks (4.75, 9.5,14.25 and 19% of protein in isocaloric diets with normal content of mineral and vitamins), being subsequently infected with two strains of Trypanosoma cruzi: 10(5) trypomastigotes of Y strain or 14(5) trypomastigotes of CL strain. The same diet was maintained for all animals and the infection wasfollowed up by evaluation of blood parasites, mortality and intensity of lesions in the heart and skeleton muscle. Only severe protein restriction (4.75%) induced decrease in resistance to the infection with both the Y and CL strains of T. cruzi, which resulted in higher parasitemia and mortality. The inflammatory lesions in heart and skeleton muscle were less extensive in groups with severe protein restriction despite the increased number of parasite in muscle cells. Depression of immune mechanisms could be responsiblefor the reduced resistance and reduced inflammatory reaction after T. cruzi infection in severely protein restricted animals. |
format |
Article in Journal/Newspaper |
author |
Nildete G.L. Gomes Fausto E.L. Pereira Gisele G.S. Domingues Jesse R. Alves |
author_facet |
Nildete G.L. Gomes Fausto E.L. Pereira Gisele G.S. Domingues Jesse R. Alves |
author_sort |
Nildete G.L. Gomes |
title |
Effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with Trypanosoma cruzi |
title_short |
Effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with Trypanosoma cruzi |
title_full |
Effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with Trypanosoma cruzi |
title_fullStr |
Effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with Trypanosoma cruzi |
title_full_unstemmed |
Effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with Trypanosoma cruzi |
title_sort |
effects of severe protein restriction in levels of parasitemia and in mortality of mice accutely infected with trypanosoma cruzi |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1994 |
url |
https://doi.org/10.1590/S0037-86821994000100005 https://doaj.org/article/e160bdb7a21f4ab993591974188c1954 |
long_lat |
ENVELOPE(-112.453,-112.453,57.591,57.591) |
geographic |
Arctic The ''Y'' |
geographic_facet |
Arctic The ''Y'' |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 27, Iss 1, Pp 19-24 (1994) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821994000100005&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86821994000100005 https://doaj.org/article/e160bdb7a21f4ab993591974188c1954 |
op_doi |
https://doi.org/10.1590/S0037-86821994000100005 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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27 |
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1 |
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19 |
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24 |
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