Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels.
BACKGROUND:Serological antibody levels are a sensitive marker of pathogen exposure, and advances in multiplex assays have created enormous potential for large-scale, integrated infectious disease surveillance. Most methods to analyze antibody measurements reduce quantitative antibody levels to serop...
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ftdoajarticles:oai:doaj.org/article:e157128c674b4dd1893dcc7071c574d1 2023-05-15T15:12:32+02:00 Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. Benjamin F Arnold Mark J van der Laan Alan E Hubbard Cathy Steel Joseph Kubofcik Katy L Hamlin Delynn M Moss Thomas B Nutman Jeffrey W Priest Patrick J Lammie 2017-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005616 https://doaj.org/article/e157128c674b4dd1893dcc7071c574d1 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5453600?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005616 https://doaj.org/article/e157128c674b4dd1893dcc7071c574d1 PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005616 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005616 2022-12-31T10:18:04Z BACKGROUND:Serological antibody levels are a sensitive marker of pathogen exposure, and advances in multiplex assays have created enormous potential for large-scale, integrated infectious disease surveillance. Most methods to analyze antibody measurements reduce quantitative antibody levels to seropositive and seronegative groups, but this can be difficult for many pathogens and may provide lower resolution information than quantitative levels. Analysis methods have predominantly maintained a single disease focus, yet integrated surveillance platforms would benefit from methodologies that work across diverse pathogens included in multiplex assays. METHODS/PRINCIPAL FINDINGS:We developed an approach to measure changes in transmission from quantitative antibody levels that can be applied to diverse pathogens of global importance. We compared age-dependent immunoglobulin G curves in repeated cross-sectional surveys between populations with differences in transmission for multiple pathogens, including: lymphatic filariasis (Wuchereria bancrofti) measured before and after mass drug administration on Mauke, Cook Islands, malaria (Plasmodium falciparum) before and after a combined insecticide and mass drug administration intervention in the Garki project, Nigeria, and enteric protozoans (Cryptosporidium parvum, Giardia intestinalis, Entamoeba histolytica), bacteria (enterotoxigenic Escherichia coli, Salmonella spp.), and viruses (norovirus groups I and II) in children living in Haiti and the USA. Age-dependent antibody curves fit with ensemble machine learning followed a characteristic shape across pathogens that aligned with predictions from basic mechanisms of humoral immunity. Differences in pathogen transmission led to shifts in fitted antibody curves that were remarkably consistent across pathogens, assays, and populations. Mean antibody levels correlated strongly with traditional measures of transmission intensity, such as the entomological inoculation rate for P. falciparum (Spearman's rho = 0.75). In both high- ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Rho ENVELOPE(-63.000,-63.000,-64.300,-64.300) PLOS Neglected Tropical Diseases 11 5 e0005616 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Benjamin F Arnold Mark J van der Laan Alan E Hubbard Cathy Steel Joseph Kubofcik Katy L Hamlin Delynn M Moss Thomas B Nutman Jeffrey W Priest Patrick J Lammie Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Serological antibody levels are a sensitive marker of pathogen exposure, and advances in multiplex assays have created enormous potential for large-scale, integrated infectious disease surveillance. Most methods to analyze antibody measurements reduce quantitative antibody levels to seropositive and seronegative groups, but this can be difficult for many pathogens and may provide lower resolution information than quantitative levels. Analysis methods have predominantly maintained a single disease focus, yet integrated surveillance platforms would benefit from methodologies that work across diverse pathogens included in multiplex assays. METHODS/PRINCIPAL FINDINGS:We developed an approach to measure changes in transmission from quantitative antibody levels that can be applied to diverse pathogens of global importance. We compared age-dependent immunoglobulin G curves in repeated cross-sectional surveys between populations with differences in transmission for multiple pathogens, including: lymphatic filariasis (Wuchereria bancrofti) measured before and after mass drug administration on Mauke, Cook Islands, malaria (Plasmodium falciparum) before and after a combined insecticide and mass drug administration intervention in the Garki project, Nigeria, and enteric protozoans (Cryptosporidium parvum, Giardia intestinalis, Entamoeba histolytica), bacteria (enterotoxigenic Escherichia coli, Salmonella spp.), and viruses (norovirus groups I and II) in children living in Haiti and the USA. Age-dependent antibody curves fit with ensemble machine learning followed a characteristic shape across pathogens that aligned with predictions from basic mechanisms of humoral immunity. Differences in pathogen transmission led to shifts in fitted antibody curves that were remarkably consistent across pathogens, assays, and populations. Mean antibody levels correlated strongly with traditional measures of transmission intensity, such as the entomological inoculation rate for P. falciparum (Spearman's rho = 0.75). In both high- ... |
format |
Article in Journal/Newspaper |
author |
Benjamin F Arnold Mark J van der Laan Alan E Hubbard Cathy Steel Joseph Kubofcik Katy L Hamlin Delynn M Moss Thomas B Nutman Jeffrey W Priest Patrick J Lammie |
author_facet |
Benjamin F Arnold Mark J van der Laan Alan E Hubbard Cathy Steel Joseph Kubofcik Katy L Hamlin Delynn M Moss Thomas B Nutman Jeffrey W Priest Patrick J Lammie |
author_sort |
Benjamin F Arnold |
title |
Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. |
title_short |
Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. |
title_full |
Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. |
title_fullStr |
Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. |
title_full_unstemmed |
Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. |
title_sort |
measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005616 https://doaj.org/article/e157128c674b4dd1893dcc7071c574d1 |
long_lat |
ENVELOPE(-63.000,-63.000,-64.300,-64.300) |
geographic |
Arctic Rho |
geographic_facet |
Arctic Rho |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 5, p e0005616 (2017) |
op_relation |
http://europepmc.org/articles/PMC5453600?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005616 https://doaj.org/article/e157128c674b4dd1893dcc7071c574d1 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005616 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
5 |
container_start_page |
e0005616 |
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