Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram
The present study aimed at evaluating clinical and laboratory aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with antiophidic serum. Twenty-one dogs were divided into three groups of seven animals each. Group I received 1mg/kg venom (sc); Group II received 1...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:e12fd32c33ba4a1aa4d13f9fd377c7ba 2023-05-15T15:09:06+02:00 Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram R. M. B. Nogueira M. Sakate F. Sangiorgio C. B. Laposy M. Melero 2007-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992007000400010 https://doaj.org/article/e12fd32c33ba4a1aa4d13f9fd377c7ba EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000400010 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000400010 1678-9199 https://doaj.org/article/e12fd32c33ba4a1aa4d13f9fd377c7ba Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 4, Pp 800-810 (2007) Crotalus durissus terrificus dogs clinical aspects laboratory aspects Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2007 ftdoajarticles https://doi.org/10.1590/S1678-91992007000400010 2022-12-31T14:42:35Z The present study aimed at evaluating clinical and laboratory aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with antiophidic serum. Twenty-one dogs were divided into three groups of seven animals each. Group I received 1mg/kg venom (sc); Group II received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution (iv); and Group III received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution containing sodium bicarbonate diluted to the dose of 4mEq/kg. The clinical signs of ataxia, sedation, flaccid paralysis, mydriasis, eyeball paralysis, mandible ptosis, sialorrhea, vomiting and diarrhea observed in the dogs were very similar to those observed in humans. The decrease in hemoglobin, hematocrit, erythrocyte, platelet and fibrinogen levels, prolongation of clotting time, prothrombin time (PT) and activated partial thromboplastin time (APTT), as well as hypocellularity in the bone marrow characterized anemia, thrombocytopenia and blood incoagulability, as well as hypofibrinogenemia and decreased bone-marrow activity. Important bleeding was not observed. Increased numbers of leukocytes and neutrophils and decreased numbers of lymphocytes and eosinophils characterized an acute inflammatory response and stress caused by generalized pain. The employed antiophidic serum was effective and all animals survived. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 13 4 800 810 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Crotalus durissus terrificus dogs clinical aspects laboratory aspects Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Crotalus durissus terrificus dogs clinical aspects laboratory aspects Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 R. M. B. Nogueira M. Sakate F. Sangiorgio C. B. Laposy M. Melero Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram |
topic_facet |
Crotalus durissus terrificus dogs clinical aspects laboratory aspects Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The present study aimed at evaluating clinical and laboratory aspects during experimental envenomation by Crotalus durissus terrificus in dogs treated with antiophidic serum. Twenty-one dogs were divided into three groups of seven animals each. Group I received 1mg/kg venom (sc); Group II received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution (iv); and Group III received 1mg/kg venom (sc), 50mg antiophidic serum (iv), and fluid therapy including 0.9% NaCl solution containing sodium bicarbonate diluted to the dose of 4mEq/kg. The clinical signs of ataxia, sedation, flaccid paralysis, mydriasis, eyeball paralysis, mandible ptosis, sialorrhea, vomiting and diarrhea observed in the dogs were very similar to those observed in humans. The decrease in hemoglobin, hematocrit, erythrocyte, platelet and fibrinogen levels, prolongation of clotting time, prothrombin time (PT) and activated partial thromboplastin time (APTT), as well as hypocellularity in the bone marrow characterized anemia, thrombocytopenia and blood incoagulability, as well as hypofibrinogenemia and decreased bone-marrow activity. Important bleeding was not observed. Increased numbers of leukocytes and neutrophils and decreased numbers of lymphocytes and eosinophils characterized an acute inflammatory response and stress caused by generalized pain. The employed antiophidic serum was effective and all animals survived. |
format |
Article in Journal/Newspaper |
author |
R. M. B. Nogueira M. Sakate F. Sangiorgio C. B. Laposy M. Melero |
author_facet |
R. M. B. Nogueira M. Sakate F. Sangiorgio C. B. Laposy M. Melero |
author_sort |
R. M. B. Nogueira |
title |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram |
title_short |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram |
title_full |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram |
title_fullStr |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram |
title_full_unstemmed |
Experimental envenomation with Crotalus durissus terrificus venom in dogs treated with antiophidic serum - part I: clinical evaluation, hematology and myelogram |
title_sort |
experimental envenomation with crotalus durissus terrificus venom in dogs treated with antiophidic serum - part i: clinical evaluation, hematology and myelogram |
publisher |
SciELO |
publishDate |
2007 |
url |
https://doi.org/10.1590/S1678-91992007000400010 https://doaj.org/article/e12fd32c33ba4a1aa4d13f9fd377c7ba |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 13, Iss 4, Pp 800-810 (2007) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992007000400010 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992007000400010 1678-9199 https://doaj.org/article/e12fd32c33ba4a1aa4d13f9fd377c7ba |
op_doi |
https://doi.org/10.1590/S1678-91992007000400010 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
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13 |
container_issue |
4 |
container_start_page |
800 |
op_container_end_page |
810 |
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