Safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria at Shecha health centre, Arba Minch, Ethiopia
Abstract Background In 2004, Ethiopia adopted artemether-lumefantrine (AL, Coartem®) as first-line treatment for the management of uncomplicated Plasmodium falciparum malaria. Continuous monitoring of AL therapeutic efficacy is crucial in Ethiopia, as per the World Health Organization (WHO) recommen...
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ftdoajarticles:oai:doaj.org/article:e118163bd6ad4e5792a327cfede8f826 2023-05-15T15:14:35+02:00 Safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria at Shecha health centre, Arba Minch, Ethiopia Kale Gubae Hussein Mohammed Heven Sime Henok Hailgiorgis Anteneh Kassahun Mare Bokretsion Gidey Mebrahtom Haile Gudissa Assefa Worku Bekele Geremew Tasew Solomon Mequanente Abay Ashenafi Assefa 2023-01-01T00:00:00Z https://doi.org/10.1186/s12936-022-04436-8 https://doaj.org/article/e118163bd6ad4e5792a327cfede8f826 EN eng BMC https://doi.org/10.1186/s12936-022-04436-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04436-8 1475-2875 https://doaj.org/article/e118163bd6ad4e5792a327cfede8f826 Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023) Therapeutic efficacy Artemether-lumefantrine Uncomplicated malaria Ethiopia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-022-04436-8 2023-01-15T01:29:42Z Abstract Background In 2004, Ethiopia adopted artemether-lumefantrine (AL, Coartem®) as first-line treatment for the management of uncomplicated Plasmodium falciparum malaria. Continuous monitoring of AL therapeutic efficacy is crucial in Ethiopia, as per the World Health Organization (WHO) recommendation. This study aimed to assess the therapeutic efficacy of AL in the treatment of uncomplicated P. falciparum infection. Methods A 28 day onearm, prospective evaluation of the clinical and parasitological response to AL was conducted at Shecha Health Centre, Arba Minch town, Southern Ethiopia. Patients were treated with six-dose regimen of AL over three days and monitored for 28 days with clinical and laboratory assessments. Participant recruitment and outcome classification was done in accordance with the 2009 WHO methods for surveillance of anti-malarial drug efficacy guidelines. Results A total of 88 study participants were enrolled and 69 of them completed the study with adequate clinical and parasitological response. Two late parasitological failures were observed, of which one was classified as a recrudescence by polymerase chain reaction (PCR). The PCRcorrected cure rate was 98.6% (95% CI 92.3–100). AL demonstrated a rapid parasite and fever clearance with no parasitaemia on day 2 and febrile cases on day 3. Gametocyte clearance was complete by day three. No serious adverse events were reported during the 28 days follow-up. Conclusion The study demonstrated high therapeutic efficacy and good safety profile of AL. This suggests the continuation of AL as the first-line drug for the treatment of uncomplicated P. falciparum malaria in Ethiopia. Periodic therapeutic efficacy studies and monitoring of markers of resistance are recommended for early detection of resistant parasites. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arba ENVELOPE(144.373,144.373,59.682,59.682) Arctic Malaria Journal 22 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Therapeutic efficacy Artemether-lumefantrine Uncomplicated malaria Ethiopia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Therapeutic efficacy Artemether-lumefantrine Uncomplicated malaria Ethiopia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Kale Gubae Hussein Mohammed Heven Sime Henok Hailgiorgis Anteneh Kassahun Mare Bokretsion Gidey Mebrahtom Haile Gudissa Assefa Worku Bekele Geremew Tasew Solomon Mequanente Abay Ashenafi Assefa Safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria at Shecha health centre, Arba Minch, Ethiopia |
topic_facet |
Therapeutic efficacy Artemether-lumefantrine Uncomplicated malaria Ethiopia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background In 2004, Ethiopia adopted artemether-lumefantrine (AL, Coartem®) as first-line treatment for the management of uncomplicated Plasmodium falciparum malaria. Continuous monitoring of AL therapeutic efficacy is crucial in Ethiopia, as per the World Health Organization (WHO) recommendation. This study aimed to assess the therapeutic efficacy of AL in the treatment of uncomplicated P. falciparum infection. Methods A 28 day onearm, prospective evaluation of the clinical and parasitological response to AL was conducted at Shecha Health Centre, Arba Minch town, Southern Ethiopia. Patients were treated with six-dose regimen of AL over three days and monitored for 28 days with clinical and laboratory assessments. Participant recruitment and outcome classification was done in accordance with the 2009 WHO methods for surveillance of anti-malarial drug efficacy guidelines. Results A total of 88 study participants were enrolled and 69 of them completed the study with adequate clinical and parasitological response. Two late parasitological failures were observed, of which one was classified as a recrudescence by polymerase chain reaction (PCR). The PCRcorrected cure rate was 98.6% (95% CI 92.3–100). AL demonstrated a rapid parasite and fever clearance with no parasitaemia on day 2 and febrile cases on day 3. Gametocyte clearance was complete by day three. No serious adverse events were reported during the 28 days follow-up. Conclusion The study demonstrated high therapeutic efficacy and good safety profile of AL. This suggests the continuation of AL as the first-line drug for the treatment of uncomplicated P. falciparum malaria in Ethiopia. Periodic therapeutic efficacy studies and monitoring of markers of resistance are recommended for early detection of resistant parasites. |
format |
Article in Journal/Newspaper |
author |
Kale Gubae Hussein Mohammed Heven Sime Henok Hailgiorgis Anteneh Kassahun Mare Bokretsion Gidey Mebrahtom Haile Gudissa Assefa Worku Bekele Geremew Tasew Solomon Mequanente Abay Ashenafi Assefa |
author_facet |
Kale Gubae Hussein Mohammed Heven Sime Henok Hailgiorgis Anteneh Kassahun Mare Bokretsion Gidey Mebrahtom Haile Gudissa Assefa Worku Bekele Geremew Tasew Solomon Mequanente Abay Ashenafi Assefa |
author_sort |
Kale Gubae |
title |
Safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria at Shecha health centre, Arba Minch, Ethiopia |
title_short |
Safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria at Shecha health centre, Arba Minch, Ethiopia |
title_full |
Safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria at Shecha health centre, Arba Minch, Ethiopia |
title_fullStr |
Safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria at Shecha health centre, Arba Minch, Ethiopia |
title_full_unstemmed |
Safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria at Shecha health centre, Arba Minch, Ethiopia |
title_sort |
safety and therapeutic efficacy of artemether-lumefantrine in the treatment of uncomplicated plasmodium falciparum malaria at shecha health centre, arba minch, ethiopia |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-022-04436-8 https://doaj.org/article/e118163bd6ad4e5792a327cfede8f826 |
long_lat |
ENVELOPE(144.373,144.373,59.682,59.682) |
geographic |
Arba Arctic |
geographic_facet |
Arba Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-10 (2023) |
op_relation |
https://doi.org/10.1186/s12936-022-04436-8 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-022-04436-8 1475-2875 https://doaj.org/article/e118163bd6ad4e5792a327cfede8f826 |
op_doi |
https://doi.org/10.1186/s12936-022-04436-8 |
container_title |
Malaria Journal |
container_volume |
22 |
container_issue |
1 |
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1766345023349063680 |