Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients.
Although Japanese encephalitis virus (JEV) is considered endemic in Indonesia, there are only limited reports of JEV infection from a small number of geographic areas within the country with the majority of these being neuroinvasive disease cases. Here, we report cases of JEV infection in non-enceph...
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ftdoajarticles:oai:doaj.org/article:e1167482141c43b69be46b93663a52e9 2023-05-15T15:06:30+02:00 Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients. Chairin Nisa Ma'roef Rama Dhenni Dewi Megawati Araniy Fadhilah Anton Lucanus I Made Artika Sri Masyeni Asri Lestarini Kartika Sari Ketut Suryana Frilasita A Yudhaputri Ungke Anton Jaya R Tedjo Sasmono Jeremy P Ledermann Ann M Powers Khin Saw Aye Myint 2020-07-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008454 https://doaj.org/article/e1167482141c43b69be46b93663a52e9 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008454 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008454 https://doaj.org/article/e1167482141c43b69be46b93663a52e9 PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008454 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008454 2022-12-31T05:46:09Z Although Japanese encephalitis virus (JEV) is considered endemic in Indonesia, there are only limited reports of JEV infection from a small number of geographic areas within the country with the majority of these being neuroinvasive disease cases. Here, we report cases of JEV infection in non-encephalitic acute febrile illness patients from Bali, Indonesia. Paired admission (S1) and discharge (S2) serum specimens from 144 acute febrile illness patients (without evidence of acute dengue virus infection) were retrospectively tested for anti-JEV IgM antibody and confirmed by plaque reduction neutralization test (PRNT) for JEV infection. Twenty-six (18.1%) patients were anti-JEV IgM-positive or equivocal in their S2 specimens, of which 5 (3.5%) and 8 (5.6%) patients met the criteria for confirmed and probable JEV infection, respectively, based on PRNT results. Notably, these non-encephalitic JE cases were less likely to have thrombocytopenia, leukopenia, and lower hematocrit compared with confirmed dengue cases of the same cohort. These findings highlight the need to consider JEV in the diagnostic algorithm for acute febrile illnesses in endemic areas and suggest that JEV as a cause of non-encephalitic disease has likely been underestimated in Indonesia. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Bali ENVELOPE(-20.233,-20.233,64.067,64.067) PLOS Neglected Tropical Diseases 14 7 e0008454 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Chairin Nisa Ma'roef Rama Dhenni Dewi Megawati Araniy Fadhilah Anton Lucanus I Made Artika Sri Masyeni Asri Lestarini Kartika Sari Ketut Suryana Frilasita A Yudhaputri Ungke Anton Jaya R Tedjo Sasmono Jeremy P Ledermann Ann M Powers Khin Saw Aye Myint Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Although Japanese encephalitis virus (JEV) is considered endemic in Indonesia, there are only limited reports of JEV infection from a small number of geographic areas within the country with the majority of these being neuroinvasive disease cases. Here, we report cases of JEV infection in non-encephalitic acute febrile illness patients from Bali, Indonesia. Paired admission (S1) and discharge (S2) serum specimens from 144 acute febrile illness patients (without evidence of acute dengue virus infection) were retrospectively tested for anti-JEV IgM antibody and confirmed by plaque reduction neutralization test (PRNT) for JEV infection. Twenty-six (18.1%) patients were anti-JEV IgM-positive or equivocal in their S2 specimens, of which 5 (3.5%) and 8 (5.6%) patients met the criteria for confirmed and probable JEV infection, respectively, based on PRNT results. Notably, these non-encephalitic JE cases were less likely to have thrombocytopenia, leukopenia, and lower hematocrit compared with confirmed dengue cases of the same cohort. These findings highlight the need to consider JEV in the diagnostic algorithm for acute febrile illnesses in endemic areas and suggest that JEV as a cause of non-encephalitic disease has likely been underestimated in Indonesia. |
format |
Article in Journal/Newspaper |
author |
Chairin Nisa Ma'roef Rama Dhenni Dewi Megawati Araniy Fadhilah Anton Lucanus I Made Artika Sri Masyeni Asri Lestarini Kartika Sari Ketut Suryana Frilasita A Yudhaputri Ungke Anton Jaya R Tedjo Sasmono Jeremy P Ledermann Ann M Powers Khin Saw Aye Myint |
author_facet |
Chairin Nisa Ma'roef Rama Dhenni Dewi Megawati Araniy Fadhilah Anton Lucanus I Made Artika Sri Masyeni Asri Lestarini Kartika Sari Ketut Suryana Frilasita A Yudhaputri Ungke Anton Jaya R Tedjo Sasmono Jeremy P Ledermann Ann M Powers Khin Saw Aye Myint |
author_sort |
Chairin Nisa Ma'roef |
title |
Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients. |
title_short |
Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients. |
title_full |
Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients. |
title_fullStr |
Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients. |
title_full_unstemmed |
Japanese encephalitis virus infection in non-encephalitic acute febrile illness patients. |
title_sort |
japanese encephalitis virus infection in non-encephalitic acute febrile illness patients. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008454 https://doaj.org/article/e1167482141c43b69be46b93663a52e9 |
long_lat |
ENVELOPE(-20.233,-20.233,64.067,64.067) |
geographic |
Arctic Bali |
geographic_facet |
Arctic Bali |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 7, p e0008454 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008454 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008454 https://doaj.org/article/e1167482141c43b69be46b93663a52e9 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008454 |
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PLOS Neglected Tropical Diseases |
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14 |
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7 |
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e0008454 |
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1766338091871633408 |