Antimalarial qinghaosu/artemisinin: The therapy worthy of a Nobel Prize
Malaria is a major cause of human morbidity and mortality in the tropical endemic countries worldwide. This is largely due to the emergence and spread of resistance to most antimalarial drugs currently available. Based on the World Health Organization recommendation, artemisinin-based combination th...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:e10e243fb1c5404a931a782ffeaaac85 2023-05-15T15:07:40+02:00 Antimalarial qinghaosu/artemisinin: The therapy worthy of a Nobel Prize Jerapan Krungkrai Sudaratana Rochanakij Krungkrai 2016-05-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2016.03.010 https://doaj.org/article/e10e243fb1c5404a931a782ffeaaac85 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169116302465 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.03.010 https://doaj.org/article/e10e243fb1c5404a931a782ffeaaac85 Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 5, Pp 371-375 (2016) Malaria Plasmodium falciparum Artemisinin Qinghaosu Discovery Chemical structure Mechanism of action Drug resistance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2016 ftdoajarticles https://doi.org/10.1016/j.apjtb.2016.03.010 2022-12-31T10:34:31Z Malaria is a major cause of human morbidity and mortality in the tropical endemic countries worldwide. This is largely due to the emergence and spread of resistance to most antimalarial drugs currently available. Based on the World Health Organization recommendation, artemisinin-based combination therapies are now used as first-line treatment for Plasmodium falciparum malaria. Artemisinin or qinghaosu (Chinese name) and its derivatives are highly potent, rapidly acting antimalarial drugs. Artemisinin was discovered in 1971 by a Chinese medical scientist Youyou Tu, who was awarded the Nobel Prize in 2015 on her discovering the antimalarial properties of qinghaosu from the traditional Chinese qinghao plant. Nevertheless, artemisinin resistance in falciparum malaria patients has first emerged on the Thai-Cambodian border in 2009, which is now prevalent across mainland Southeast Asia from Vietnam to Myanmar. Here, we reviewed malaria disease severity, history of artemisinin discovery, chemical structure, mechanism of drug action, artemisinin-based combination therapies, emergence and spread of drug resistance, including the recent findings on mechanism of resistance in the falciparum malaria parasite. This poses a serious threat to global malaria control and prompts renewed efforts for the urgent development of new antimalarial drugs. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 6 5 371 375 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Plasmodium falciparum Artemisinin Qinghaosu Discovery Chemical structure Mechanism of action Drug resistance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Malaria Plasmodium falciparum Artemisinin Qinghaosu Discovery Chemical structure Mechanism of action Drug resistance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Jerapan Krungkrai Sudaratana Rochanakij Krungkrai Antimalarial qinghaosu/artemisinin: The therapy worthy of a Nobel Prize |
topic_facet |
Malaria Plasmodium falciparum Artemisinin Qinghaosu Discovery Chemical structure Mechanism of action Drug resistance Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Malaria is a major cause of human morbidity and mortality in the tropical endemic countries worldwide. This is largely due to the emergence and spread of resistance to most antimalarial drugs currently available. Based on the World Health Organization recommendation, artemisinin-based combination therapies are now used as first-line treatment for Plasmodium falciparum malaria. Artemisinin or qinghaosu (Chinese name) and its derivatives are highly potent, rapidly acting antimalarial drugs. Artemisinin was discovered in 1971 by a Chinese medical scientist Youyou Tu, who was awarded the Nobel Prize in 2015 on her discovering the antimalarial properties of qinghaosu from the traditional Chinese qinghao plant. Nevertheless, artemisinin resistance in falciparum malaria patients has first emerged on the Thai-Cambodian border in 2009, which is now prevalent across mainland Southeast Asia from Vietnam to Myanmar. Here, we reviewed malaria disease severity, history of artemisinin discovery, chemical structure, mechanism of drug action, artemisinin-based combination therapies, emergence and spread of drug resistance, including the recent findings on mechanism of resistance in the falciparum malaria parasite. This poses a serious threat to global malaria control and prompts renewed efforts for the urgent development of new antimalarial drugs. |
format |
Article in Journal/Newspaper |
author |
Jerapan Krungkrai Sudaratana Rochanakij Krungkrai |
author_facet |
Jerapan Krungkrai Sudaratana Rochanakij Krungkrai |
author_sort |
Jerapan Krungkrai |
title |
Antimalarial qinghaosu/artemisinin: The therapy worthy of a Nobel Prize |
title_short |
Antimalarial qinghaosu/artemisinin: The therapy worthy of a Nobel Prize |
title_full |
Antimalarial qinghaosu/artemisinin: The therapy worthy of a Nobel Prize |
title_fullStr |
Antimalarial qinghaosu/artemisinin: The therapy worthy of a Nobel Prize |
title_full_unstemmed |
Antimalarial qinghaosu/artemisinin: The therapy worthy of a Nobel Prize |
title_sort |
antimalarial qinghaosu/artemisinin: the therapy worthy of a nobel prize |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2016 |
url |
https://doi.org/10.1016/j.apjtb.2016.03.010 https://doaj.org/article/e10e243fb1c5404a931a782ffeaaac85 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 6, Iss 5, Pp 371-375 (2016) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169116302465 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2016.03.010 https://doaj.org/article/e10e243fb1c5404a931a782ffeaaac85 |
op_doi |
https://doi.org/10.1016/j.apjtb.2016.03.010 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
6 |
container_issue |
5 |
container_start_page |
371 |
op_container_end_page |
375 |
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1766339118672904192 |