Efectos de la ingestión de una dieta con alto contenido en grasas en ratas Wistar crónicamente infectadas con Trypanosoma cruzi
Abstract: The effects of ingesting a high fat diet on albino rats (R. norvegicus) chronically infected with Trypanosome cruzi “Planalto” were researched using serological and parasitological diagnostic tests, body mass index (BMI) quantification, detection of C-Protein Reactive (CPR), evaluation of...
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Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales
2009
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Online Access: | https://doaj.org/article/e0e0170044ae44a6b024d6bb6ba655a3 |
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ftdoajarticles:oai:doaj.org/article:e0e0170044ae44a6b024d6bb6ba655a3 2023-10-01T03:54:22+02:00 Efectos de la ingestión de una dieta con alto contenido en grasas en ratas Wistar crónicamente infectadas con Trypanosoma cruzi Paredes José Leonardo Moreno Elio A Premoli Gloria Alarcón Maritza Lugo de Yarbuh Ana Villarreal Juana Araujo Sonia Borges Rafael 2009-06-01T00:00:00Z https://doaj.org/article/e0e0170044ae44a6b024d6bb6ba655a3 EN ES eng spa Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales https://drive.google.com/file/d/1qVuS82MT9cjzpMOCB-92jagl6CPzv0_W/view https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/e0e0170044ae44a6b024d6bb6ba655a3 Kasmera, Vol 37, Iss 1, Pp 74-89 (2009) Trypanosoma cruzi dieta rica en grasas rata Wistar infección chagásica crónica high fat diet Wistar rats chronic chagasic infection rata Wistar infección chagásica crónica Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles 2023-09-03T00:47:43Z Abstract: The effects of ingesting a high fat diet on albino rats (R. norvegicus) chronically infected with Trypanosome cruzi “Planalto” were researched using serological and parasitological diagnostic tests, body mass index (BMI) quantification, detection of C-Protein Reactive (CPR), evaluation of the plasmatic lipid levels (total cholesterol, high density lipoproteins HDL and triglycerides) and the presence of lipidic deposits in the aorta artery. During the course of the chagasic infection, patent parasitemias were detected between the ages of 10 and 35 days post-infection (pi) with a maximum average of 36.68 ± 2 tryps/mm³ of blood at 25 days. At 90 days pi, the absence of parasitemias and the presence of IgG anti T. cruzi antibodies were in evidence. The chagasic rats in chronic phase (A) and the healthy controls (C) submitted to a high fat diet showed: 1. Significant variations (p0.05) in the BMI, in comparison with the rat groups receiving a normal diet (B: infected and D: healthy rats); 2. A discrete CRP reaction in the serum of infected rats B; 3. A significant increase was shown in the total cholesterol levels, HDL cholesterol and triglycerides for groups A and C in comparison with control groups B and D (p0.05). The histological study of rat arteries in group A revealed important lipid deposits located in the muscular layer near the intimal and adventitial layer. These results suggest that the increase in plasmatic lipid levels stimulated by the infectious process are the main mechanisms through which T. cruzi could be influencing the initiation or the progression of atheromatous plaque. Se investigan los efectos de la ingestión de una dieta con alto contenido en grasas en ratas albinas (R. norvegicus) crónicamente infectadas con Trypanosoma cruzi “Planalto”, mediante pruebas de diagnóstico sero-parasitológicas, cuantificación del Índice de Masa Corporal (IMC), detección de la Proteína C Reactiva (PCR), evaluación de los niveles de lípidos plasmáticos (colesterol total, lipoproteínas de alta densidad - ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Alta Arctic Rata ENVELOPE(19.216,19.216,69.928,69.928) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish |
topic |
Trypanosoma cruzi dieta rica en grasas rata Wistar infección chagásica crónica high fat diet Wistar rats chronic chagasic infection rata Wistar infección chagásica crónica Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Trypanosoma cruzi dieta rica en grasas rata Wistar infección chagásica crónica high fat diet Wistar rats chronic chagasic infection rata Wistar infección chagásica crónica Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Paredes José Leonardo Moreno Elio A Premoli Gloria Alarcón Maritza Lugo de Yarbuh Ana Villarreal Juana Araujo Sonia Borges Rafael Efectos de la ingestión de una dieta con alto contenido en grasas en ratas Wistar crónicamente infectadas con Trypanosoma cruzi |
topic_facet |
Trypanosoma cruzi dieta rica en grasas rata Wistar infección chagásica crónica high fat diet Wistar rats chronic chagasic infection rata Wistar infección chagásica crónica Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Abstract: The effects of ingesting a high fat diet on albino rats (R. norvegicus) chronically infected with Trypanosome cruzi “Planalto” were researched using serological and parasitological diagnostic tests, body mass index (BMI) quantification, detection of C-Protein Reactive (CPR), evaluation of the plasmatic lipid levels (total cholesterol, high density lipoproteins HDL and triglycerides) and the presence of lipidic deposits in the aorta artery. During the course of the chagasic infection, patent parasitemias were detected between the ages of 10 and 35 days post-infection (pi) with a maximum average of 36.68 ± 2 tryps/mm³ of blood at 25 days. At 90 days pi, the absence of parasitemias and the presence of IgG anti T. cruzi antibodies were in evidence. The chagasic rats in chronic phase (A) and the healthy controls (C) submitted to a high fat diet showed: 1. Significant variations (p0.05) in the BMI, in comparison with the rat groups receiving a normal diet (B: infected and D: healthy rats); 2. A discrete CRP reaction in the serum of infected rats B; 3. A significant increase was shown in the total cholesterol levels, HDL cholesterol and triglycerides for groups A and C in comparison with control groups B and D (p0.05). The histological study of rat arteries in group A revealed important lipid deposits located in the muscular layer near the intimal and adventitial layer. These results suggest that the increase in plasmatic lipid levels stimulated by the infectious process are the main mechanisms through which T. cruzi could be influencing the initiation or the progression of atheromatous plaque. Se investigan los efectos de la ingestión de una dieta con alto contenido en grasas en ratas albinas (R. norvegicus) crónicamente infectadas con Trypanosoma cruzi “Planalto”, mediante pruebas de diagnóstico sero-parasitológicas, cuantificación del Índice de Masa Corporal (IMC), detección de la Proteína C Reactiva (PCR), evaluación de los niveles de lípidos plasmáticos (colesterol total, lipoproteínas de alta densidad - ... |
format |
Article in Journal/Newspaper |
author |
Paredes José Leonardo Moreno Elio A Premoli Gloria Alarcón Maritza Lugo de Yarbuh Ana Villarreal Juana Araujo Sonia Borges Rafael |
author_facet |
Paredes José Leonardo Moreno Elio A Premoli Gloria Alarcón Maritza Lugo de Yarbuh Ana Villarreal Juana Araujo Sonia Borges Rafael |
author_sort |
Paredes José Leonardo |
title |
Efectos de la ingestión de una dieta con alto contenido en grasas en ratas Wistar crónicamente infectadas con Trypanosoma cruzi |
title_short |
Efectos de la ingestión de una dieta con alto contenido en grasas en ratas Wistar crónicamente infectadas con Trypanosoma cruzi |
title_full |
Efectos de la ingestión de una dieta con alto contenido en grasas en ratas Wistar crónicamente infectadas con Trypanosoma cruzi |
title_fullStr |
Efectos de la ingestión de una dieta con alto contenido en grasas en ratas Wistar crónicamente infectadas con Trypanosoma cruzi |
title_full_unstemmed |
Efectos de la ingestión de una dieta con alto contenido en grasas en ratas Wistar crónicamente infectadas con Trypanosoma cruzi |
title_sort |
efectos de la ingestión de una dieta con alto contenido en grasas en ratas wistar crónicamente infectadas con trypanosoma cruzi |
publisher |
Universidad del Zulia,Facultad de Medicina,Departamento de Enfermedades Infecciosas y Tropicales |
publishDate |
2009 |
url |
https://doaj.org/article/e0e0170044ae44a6b024d6bb6ba655a3 |
long_lat |
ENVELOPE(19.216,19.216,69.928,69.928) |
geographic |
Alta Arctic Rata |
geographic_facet |
Alta Arctic Rata |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Kasmera, Vol 37, Iss 1, Pp 74-89 (2009) |
op_relation |
https://drive.google.com/file/d/1qVuS82MT9cjzpMOCB-92jagl6CPzv0_W/view https://doaj.org/toc/0075-5222 https://doaj.org/toc/2477-9628 0075-5222 2477-9628 https://doaj.org/article/e0e0170044ae44a6b024d6bb6ba655a3 |
_version_ |
1778521911044603904 |