Antioxidant and antiglycation properties of two mango (Mangifera indica L.) cultivars from Senegal

• Published in: Asian Pacific Journal of Tropical Biomedicine
• Main Authors: Samba Fama Ndoye, Didier Fraisse, Blandine Akendengué, Mbaye Diaw Dioum, Rokhaya Sylla Gueye, Cheikh Sall, Insa Seck, Catherine Felgines, Matar Seck, François Senejoux
• Format: Article in Journal/Newspaper
• Language: English
• Published: Wolters Kluwer Medknow Publications 2018
• Subjects: mangifera indica; cultivars; polyphenols; antioxidant; antiglycation; Arctic medicine. Tropical medicine; RC955-962; Biology (General); QH301-705.5; Arctic
• Online Access: https://doi.org/10.4103/2221-1691.227994; https://doaj.org/article/e0ab4de57dae479f8dc34a4032fd12eb

Objective: To evaluate the total phenolic contents, antioxidant and antiglycation activities of leaves, barks, roots and kernels from two cultivars of Mangifera indica (Anacardiaceae). Methods: Total phenolic contents were determined by using Folin-Ciocalteu's method. The antioxidant activities were assessed by three different protocols including DPPH, oxygen radical absorbance capacity and iron (II) chelation assays. In addition, in vitro bovine serum albumin/D-ribose assay was chosen to evaluate the antiglycation properties of the extracts. Results: All the investigated extracts were found to contain high level of total phenols as well as potent antioxidant activities. Kernel extracts showed the highest total phenol contents and DPPH radical scavenging activities whereas higher oxygen radical absorbance capacity values were observed for leave, root and bark extracts. Besides, extracts from leaves, roots and barks from both cultivars exhibited potent inhibitory effects against the formation of advanced glycation end products, with IC50 values lower than the standard positive control aminoguanidine. Conclusions: The potent antiglycation and antioxidative activities of these two Mangifera indica cultivars suggest a possible role in targeting aging, diabetic complications and oxidative stress related diseases.