Evaluation of the reference value for the Montenegro skin test
Abstract:INTRODUCTION:The Montenegro skin test (MST) has good clinical applicability and low cost for the diagnosis of American tegumentary leishmaniasis (ATL). However, no studies have validated the reference value (5mm) typically used to discriminate positive and negative results. We investigated...
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ftdoajarticles:oai:doaj.org/article:e0a3ebe7835046e4a31edaf6f4513e40 2023-05-15T15:09:57+02:00 Evaluation of the reference value for the Montenegro skin test Cissiara Manetti Skraba Tatiane França Perles de Mello Raíssa Bocchi Pedroso Érika Cristina Ferreira Izabel Galhardo Demarchi Sandra Mara Alessi Aristides Maria Valdrinez Campana Lonardoni Thaís Gomes Verzignassi Silveira 2015-08-01T00:00:00Z https://doi.org/10.1590/0037-8682-0067-2015 https://doaj.org/article/e0a3ebe7835046e4a31edaf6f4513e40 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000400437&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0067-2015 https://doaj.org/article/e0a3ebe7835046e4a31edaf6f4513e40 Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 4, Pp 437-444 (2015) Cutaneous leishmaniasis Montenegro skin test Cut-off value Diagnosis Arctic medicine. Tropical medicine RC955-962 article 2015 ftdoajarticles https://doi.org/10.1590/0037-8682-0067-2015 2022-12-30T23:10:30Z Abstract:INTRODUCTION:The Montenegro skin test (MST) has good clinical applicability and low cost for the diagnosis of American tegumentary leishmaniasis (ATL). However, no studies have validated the reference value (5mm) typically used to discriminate positive and negative results. We investigated MST results and evaluated its performance using different cut-off points.METHODS:The results of laboratory tests for 4,256 patients with suspected ATL were analyzed, and 1,182 individuals were found to fulfill the established criteria. Two groups were formed. The positive cutaneous leishmaniasis (PCL) group included patients with skin lesions and positive direct search for parasites (DS) results. The negative cutaneous leishmaniasis (NCL) group included patients with skin lesions with evolution up to 2 months, negative DS results, and negative indirect immunofluorescence assay results who were residents of urban areas that were reported to be probable sites of infection at domiciles and peridomiciles.RESULTS:The PCL and NCL groups included 769 and 413 individuals, respectively. The mean ± standard deviation MST in the PCL group was 12.62 ± 5.91mm [95% confidence interval (CI): 12.20-13.04], and that in the NCL group was 1.43 ± 2.17mm (95% CI: 1.23-1.63). Receiver-operating characteristic curve analysis indicated 97.4% sensitivity and 93.9% specificity for a cut-off of 5mm and 95.8% sensitivity and 97.1% specificity for a cut-off of 6mm.CONCLUSIONS:Either 5mm or 6mm could be used as the cut-off value for diagnosing ATL, as both values had high sensitivity and specificity. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 48 4 437 444 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Cutaneous leishmaniasis Montenegro skin test Cut-off value Diagnosis Arctic medicine. Tropical medicine RC955-962 |
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Cutaneous leishmaniasis Montenegro skin test Cut-off value Diagnosis Arctic medicine. Tropical medicine RC955-962 Cissiara Manetti Skraba Tatiane França Perles de Mello Raíssa Bocchi Pedroso Érika Cristina Ferreira Izabel Galhardo Demarchi Sandra Mara Alessi Aristides Maria Valdrinez Campana Lonardoni Thaís Gomes Verzignassi Silveira Evaluation of the reference value for the Montenegro skin test |
topic_facet |
Cutaneous leishmaniasis Montenegro skin test Cut-off value Diagnosis Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract:INTRODUCTION:The Montenegro skin test (MST) has good clinical applicability and low cost for the diagnosis of American tegumentary leishmaniasis (ATL). However, no studies have validated the reference value (5mm) typically used to discriminate positive and negative results. We investigated MST results and evaluated its performance using different cut-off points.METHODS:The results of laboratory tests for 4,256 patients with suspected ATL were analyzed, and 1,182 individuals were found to fulfill the established criteria. Two groups were formed. The positive cutaneous leishmaniasis (PCL) group included patients with skin lesions and positive direct search for parasites (DS) results. The negative cutaneous leishmaniasis (NCL) group included patients with skin lesions with evolution up to 2 months, negative DS results, and negative indirect immunofluorescence assay results who were residents of urban areas that were reported to be probable sites of infection at domiciles and peridomiciles.RESULTS:The PCL and NCL groups included 769 and 413 individuals, respectively. The mean ± standard deviation MST in the PCL group was 12.62 ± 5.91mm [95% confidence interval (CI): 12.20-13.04], and that in the NCL group was 1.43 ± 2.17mm (95% CI: 1.23-1.63). Receiver-operating characteristic curve analysis indicated 97.4% sensitivity and 93.9% specificity for a cut-off of 5mm and 95.8% sensitivity and 97.1% specificity for a cut-off of 6mm.CONCLUSIONS:Either 5mm or 6mm could be used as the cut-off value for diagnosing ATL, as both values had high sensitivity and specificity. |
format |
Article in Journal/Newspaper |
author |
Cissiara Manetti Skraba Tatiane França Perles de Mello Raíssa Bocchi Pedroso Érika Cristina Ferreira Izabel Galhardo Demarchi Sandra Mara Alessi Aristides Maria Valdrinez Campana Lonardoni Thaís Gomes Verzignassi Silveira |
author_facet |
Cissiara Manetti Skraba Tatiane França Perles de Mello Raíssa Bocchi Pedroso Érika Cristina Ferreira Izabel Galhardo Demarchi Sandra Mara Alessi Aristides Maria Valdrinez Campana Lonardoni Thaís Gomes Verzignassi Silveira |
author_sort |
Cissiara Manetti Skraba |
title |
Evaluation of the reference value for the Montenegro skin test |
title_short |
Evaluation of the reference value for the Montenegro skin test |
title_full |
Evaluation of the reference value for the Montenegro skin test |
title_fullStr |
Evaluation of the reference value for the Montenegro skin test |
title_full_unstemmed |
Evaluation of the reference value for the Montenegro skin test |
title_sort |
evaluation of the reference value for the montenegro skin test |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2015 |
url |
https://doi.org/10.1590/0037-8682-0067-2015 https://doaj.org/article/e0a3ebe7835046e4a31edaf6f4513e40 |
geographic |
Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 48, Iss 4, Pp 437-444 (2015) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822015000400437&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0067-2015 https://doaj.org/article/e0a3ebe7835046e4a31edaf6f4513e40 |
op_doi |
https://doi.org/10.1590/0037-8682-0067-2015 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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48 |
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4 |
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437 |
op_container_end_page |
444 |
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