Paradox of vaccination: is vaccination really effective against avian flu epidemics?
Although vaccination can be a useful tool for control of avian influenza epidemics, it might engender emergence of a vaccine-resistant strain. Field and experimental studies show that some avian influenza strains acquire resistance ability against vaccination. We investigated, in the context of the...
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ftdoajarticles:oai:doaj.org/article:e078e3109512406bb1631082a1f8c740 2023-05-15T15:34:31+02:00 Paradox of vaccination: is vaccination really effective against avian flu epidemics? Shingo Iwami Takafumi Suzuki Yasuhiro Takeuchi 2009-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0004915 https://doaj.org/article/e078e3109512406bb1631082a1f8c740 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2657368?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0004915 https://doaj.org/article/e078e3109512406bb1631082a1f8c740 PLoS ONE, Vol 4, Iss 3, p e4915 (2009) Medicine R Science Q article 2009 ftdoajarticles https://doi.org/10.1371/journal.pone.0004915 2022-12-31T14:39:20Z Although vaccination can be a useful tool for control of avian influenza epidemics, it might engender emergence of a vaccine-resistant strain. Field and experimental studies show that some avian influenza strains acquire resistance ability against vaccination. We investigated, in the context of the emergence of a vaccine-resistant strain, whether a vaccination program can prevent the spread of infectious disease. We also investigated how losses from immunization by vaccination imposed by the resistant strain affect the spread of the disease.We designed and analyzed a deterministic compartment model illustrating transmission of vaccine-sensitive and vaccine-resistant strains during a vaccination program. We investigated how the loss of protection effectiveness impacts the program. Results show that a vaccination to prevent the spread of disease can instead spread the disease when the resistant strain is less virulent than the sensitive strain. If the loss is high, the program does not prevent the spread of the resistant strain despite a large prevalence rate of the program. The epidemic's final size can be larger than that before the vaccination program. We propose how to use poor vaccines, which have a large loss, to maximize program effects and describe various program risks, which can be estimated using available epidemiological data.We presented clear and simple concepts to elucidate vaccination program guidelines to avoid negative program effects. Using our theory, monitoring the virulence of the resistant strain and investigating the loss caused by the resistant strain better development of vaccination strategies is possible. Article in Journal/Newspaper Avian flu Directory of Open Access Journals: DOAJ Articles PLoS ONE 4 3 e4915 |
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Directory of Open Access Journals: DOAJ Articles |
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Medicine R Science Q |
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Medicine R Science Q Shingo Iwami Takafumi Suzuki Yasuhiro Takeuchi Paradox of vaccination: is vaccination really effective against avian flu epidemics? |
topic_facet |
Medicine R Science Q |
description |
Although vaccination can be a useful tool for control of avian influenza epidemics, it might engender emergence of a vaccine-resistant strain. Field and experimental studies show that some avian influenza strains acquire resistance ability against vaccination. We investigated, in the context of the emergence of a vaccine-resistant strain, whether a vaccination program can prevent the spread of infectious disease. We also investigated how losses from immunization by vaccination imposed by the resistant strain affect the spread of the disease.We designed and analyzed a deterministic compartment model illustrating transmission of vaccine-sensitive and vaccine-resistant strains during a vaccination program. We investigated how the loss of protection effectiveness impacts the program. Results show that a vaccination to prevent the spread of disease can instead spread the disease when the resistant strain is less virulent than the sensitive strain. If the loss is high, the program does not prevent the spread of the resistant strain despite a large prevalence rate of the program. The epidemic's final size can be larger than that before the vaccination program. We propose how to use poor vaccines, which have a large loss, to maximize program effects and describe various program risks, which can be estimated using available epidemiological data.We presented clear and simple concepts to elucidate vaccination program guidelines to avoid negative program effects. Using our theory, monitoring the virulence of the resistant strain and investigating the loss caused by the resistant strain better development of vaccination strategies is possible. |
format |
Article in Journal/Newspaper |
author |
Shingo Iwami Takafumi Suzuki Yasuhiro Takeuchi |
author_facet |
Shingo Iwami Takafumi Suzuki Yasuhiro Takeuchi |
author_sort |
Shingo Iwami |
title |
Paradox of vaccination: is vaccination really effective against avian flu epidemics? |
title_short |
Paradox of vaccination: is vaccination really effective against avian flu epidemics? |
title_full |
Paradox of vaccination: is vaccination really effective against avian flu epidemics? |
title_fullStr |
Paradox of vaccination: is vaccination really effective against avian flu epidemics? |
title_full_unstemmed |
Paradox of vaccination: is vaccination really effective against avian flu epidemics? |
title_sort |
paradox of vaccination: is vaccination really effective against avian flu epidemics? |
publisher |
Public Library of Science (PLoS) |
publishDate |
2009 |
url |
https://doi.org/10.1371/journal.pone.0004915 https://doaj.org/article/e078e3109512406bb1631082a1f8c740 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_source |
PLoS ONE, Vol 4, Iss 3, p e4915 (2009) |
op_relation |
http://europepmc.org/articles/PMC2657368?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0004915 https://doaj.org/article/e078e3109512406bb1631082a1f8c740 |
op_doi |
https://doi.org/10.1371/journal.pone.0004915 |
container_title |
PLoS ONE |
container_volume |
4 |
container_issue |
3 |
container_start_page |
e4915 |
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1766364879408594944 |