Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism
ABSTRACT Orthohantaviruses (genus Orthohantavirus) are a diverse group of viruses that are closely associated with their natural hosts (rodents, shrews, and moles). Several orthohantaviruses cause severe disease in humans. Central and western Europe are areas with emerging orthohantavirus occurrence...
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American Society for Microbiology
2022
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ftdoajarticles:oai:doaj.org/article:e04fdb0579ca461abaf6204197181377 2023-05-15T17:12:40+02:00 Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism Václav Hönig Jan Kamiš Aneta Maršíková Tereza Matějková Pavel Stopka Anna Mácová Daniel Růžek Jana Kvičerová 2022-10-01T00:00:00Z https://doi.org/10.1128/spectrum.01306-22 https://doaj.org/article/e04fdb0579ca461abaf6204197181377 EN eng American Society for Microbiology https://journals.asm.org/doi/10.1128/spectrum.01306-22 https://doaj.org/toc/2165-0497 doi:10.1128/spectrum.01306-22 2165-0497 https://doaj.org/article/e04fdb0579ca461abaf6204197181377 Microbiology Spectrum, Vol 10, Iss 5 (2022) Kurkino virus Tula virus Seewis virus Asikkala virus rodents Eulipotyphla Microbiology QR1-502 article 2022 ftdoajarticles https://doi.org/10.1128/spectrum.01306-22 2022-12-30T20:55:19Z ABSTRACT Orthohantaviruses (genus Orthohantavirus) are a diverse group of viruses that are closely associated with their natural hosts (rodents, shrews, and moles). Several orthohantaviruses cause severe disease in humans. Central and western Europe are areas with emerging orthohantavirus occurrences. In our study, several orthohantaviruses, including the pathogenic Kurkino virus (KURV), were detected in their natural hosts trapped at several study sites in the Czech Republic. KURV was detected mainly in its typical host, the striped field mouse (Apodemus agrarius). Nevertheless, spillover infections were also detected in wood mice (Apodemus sylvaticus) and common voles (Microtus arvalis). Similarly, Tula virus (TULV) was found primarily in common voles, and events of spillover to rodents of other host species, including Apodemus spp., were recorded. In addition, unlike most previous studies, different tissues were sampled and compared to assess their suitability for orthohantavirus screening and possible tissue tropism. Our data suggest possible virus-specific tissue tropism in rodent hosts. TULV was most commonly detected in the lung tissue, whereas KURV was more common in the liver, spleen, and brain. Moreover, Seewis and Asikkala viruses were detected in randomly found common shrews (Sorex araneus). In conclusion, we have demonstrated the presence of human-pathogenic KURV and the potentially pathogenic TULV in their typical hosts as well as their spillover to atypical host species belonging to another family. Furthermore, we suggest the possibility of virus-specific tissue tropism of orthohantaviruses in their natural hosts. IMPORTANCE Orthohantaviruses (genus Orthohantavirus, family Hantaviridae) are a diverse group of globally distributed viruses that are closely associated with their natural hosts. Some orthohantaviruses are capable of infecting humans and causing severe disease. Orthohantaviruses are considered emerging pathogens due to their ever-increasing diversity and increasing numbers of disease ... Article in Journal/Newspaper Microtus arvalis Directory of Open Access Journals: DOAJ Articles Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) Microbiology Spectrum 10 5 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Kurkino virus Tula virus Seewis virus Asikkala virus rodents Eulipotyphla Microbiology QR1-502 |
spellingShingle |
Kurkino virus Tula virus Seewis virus Asikkala virus rodents Eulipotyphla Microbiology QR1-502 Václav Hönig Jan Kamiš Aneta Maršíková Tereza Matějková Pavel Stopka Anna Mácová Daniel Růžek Jana Kvičerová Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism |
topic_facet |
Kurkino virus Tula virus Seewis virus Asikkala virus rodents Eulipotyphla Microbiology QR1-502 |
description |
ABSTRACT Orthohantaviruses (genus Orthohantavirus) are a diverse group of viruses that are closely associated with their natural hosts (rodents, shrews, and moles). Several orthohantaviruses cause severe disease in humans. Central and western Europe are areas with emerging orthohantavirus occurrences. In our study, several orthohantaviruses, including the pathogenic Kurkino virus (KURV), were detected in their natural hosts trapped at several study sites in the Czech Republic. KURV was detected mainly in its typical host, the striped field mouse (Apodemus agrarius). Nevertheless, spillover infections were also detected in wood mice (Apodemus sylvaticus) and common voles (Microtus arvalis). Similarly, Tula virus (TULV) was found primarily in common voles, and events of spillover to rodents of other host species, including Apodemus spp., were recorded. In addition, unlike most previous studies, different tissues were sampled and compared to assess their suitability for orthohantavirus screening and possible tissue tropism. Our data suggest possible virus-specific tissue tropism in rodent hosts. TULV was most commonly detected in the lung tissue, whereas KURV was more common in the liver, spleen, and brain. Moreover, Seewis and Asikkala viruses were detected in randomly found common shrews (Sorex araneus). In conclusion, we have demonstrated the presence of human-pathogenic KURV and the potentially pathogenic TULV in their typical hosts as well as their spillover to atypical host species belonging to another family. Furthermore, we suggest the possibility of virus-specific tissue tropism of orthohantaviruses in their natural hosts. IMPORTANCE Orthohantaviruses (genus Orthohantavirus, family Hantaviridae) are a diverse group of globally distributed viruses that are closely associated with their natural hosts. Some orthohantaviruses are capable of infecting humans and causing severe disease. Orthohantaviruses are considered emerging pathogens due to their ever-increasing diversity and increasing numbers of disease ... |
format |
Article in Journal/Newspaper |
author |
Václav Hönig Jan Kamiš Aneta Maršíková Tereza Matějková Pavel Stopka Anna Mácová Daniel Růžek Jana Kvičerová |
author_facet |
Václav Hönig Jan Kamiš Aneta Maršíková Tereza Matějková Pavel Stopka Anna Mácová Daniel Růžek Jana Kvičerová |
author_sort |
Václav Hönig |
title |
Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism |
title_short |
Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism |
title_full |
Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism |
title_fullStr |
Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism |
title_full_unstemmed |
Orthohantaviruses in Reservoir and Atypical Hosts in the Czech Republic: Spillover Infection and Indication of Virus-Specific Tissue Tropism |
title_sort |
orthohantaviruses in reservoir and atypical hosts in the czech republic: spillover infection and indication of virus-specific tissue tropism |
publisher |
American Society for Microbiology |
publishDate |
2022 |
url |
https://doi.org/10.1128/spectrum.01306-22 https://doaj.org/article/e04fdb0579ca461abaf6204197181377 |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_source |
Microbiology Spectrum, Vol 10, Iss 5 (2022) |
op_relation |
https://journals.asm.org/doi/10.1128/spectrum.01306-22 https://doaj.org/toc/2165-0497 doi:10.1128/spectrum.01306-22 2165-0497 https://doaj.org/article/e04fdb0579ca461abaf6204197181377 |
op_doi |
https://doi.org/10.1128/spectrum.01306-22 |
container_title |
Microbiology Spectrum |
container_volume |
10 |
container_issue |
5 |
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1766069449537880064 |