Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand

• Published in: Malaria Journal
• Main Authors: Natpasit Chaianantakul, Tippawan Sungkapong, Jirapinya Changpad, Keawalin Thongma, Sasiwimon Sim-ut, Morakot Kaewthamasorn
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2021
• Subjects: Malaria; Plasmodium falciparum; Gene polymorphism; Variable surface antigens; SURFIN; Surf gene; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1186/s12936-021-03876-y; https://doaj.org/article/dfe23b4f5f3f462b9fb98e193d766cea

Highlights The regions of SURFIN1.1 were identified: SURFIN1.1 is comprised of extracellular, transmembrane (TM), and intracellular regions. Nucleotide and amino acid sequences of the extracellular region of P. falciparum SURFIN1.1 from a total of 31 field isolates were obtained and analyzed for genetic polymorphism: six different haplotypes were identified. The extracellular region of the SURFIN1.1 among field isolates was conserved, especially in the cysteine-rich domain (CRD) sub-region. High polymorphism was shown in the variable region 2 (Var2), followed by N-terminal (N-ter) and variable region 1 (Var1), respectively. The findings presented herein may enable the discovery and development of a novel SURFIN-based vaccine for prevention and control of malaria.