Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand
Highlights The regions of SURFIN1.1 were identified: SURFIN1.1 is comprised of extracellular, transmembrane (TM), and intracellular regions. Nucleotide and amino acid sequences of the extracellular region of P. falciparum SURFIN1.1 from a total of 31 field isolates were obtained and analyzed for gen...
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ftdoajarticles:oai:doaj.org/article:dfe23b4f5f3f462b9fb98e193d766cea 2023-05-15T15:03:04+02:00 Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand Natpasit Chaianantakul Tippawan Sungkapong Jirapinya Changpad Keawalin Thongma Sasiwimon Sim-ut Morakot Kaewthamasorn 2021-08-01T00:00:00Z https://doi.org/10.1186/s12936-021-03876-y https://doaj.org/article/dfe23b4f5f3f462b9fb98e193d766cea EN eng BMC https://doi.org/10.1186/s12936-021-03876-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03876-y 1475-2875 https://doaj.org/article/dfe23b4f5f3f462b9fb98e193d766cea Malaria Journal, Vol 20, Iss 1, Pp 1-14 (2021) Malaria Plasmodium falciparum Gene polymorphism Variable surface antigens SURFIN Surf gene Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2021 ftdoajarticles https://doi.org/10.1186/s12936-021-03876-y 2022-12-31T14:32:37Z Highlights The regions of SURFIN1.1 were identified: SURFIN1.1 is comprised of extracellular, transmembrane (TM), and intracellular regions. Nucleotide and amino acid sequences of the extracellular region of P. falciparum SURFIN1.1 from a total of 31 field isolates were obtained and analyzed for genetic polymorphism: six different haplotypes were identified. The extracellular region of the SURFIN1.1 among field isolates was conserved, especially in the cysteine-rich domain (CRD) sub-region. High polymorphism was shown in the variable region 2 (Var2), followed by N-terminal (N-ter) and variable region 1 (Var1), respectively. The findings presented herein may enable the discovery and development of a novel SURFIN-based vaccine for prevention and control of malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 20 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Malaria Plasmodium falciparum Gene polymorphism Variable surface antigens SURFIN Surf gene Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Plasmodium falciparum Gene polymorphism Variable surface antigens SURFIN Surf gene Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Natpasit Chaianantakul Tippawan Sungkapong Jirapinya Changpad Keawalin Thongma Sasiwimon Sim-ut Morakot Kaewthamasorn Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand |
topic_facet |
Malaria Plasmodium falciparum Gene polymorphism Variable surface antigens SURFIN Surf gene Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Highlights The regions of SURFIN1.1 were identified: SURFIN1.1 is comprised of extracellular, transmembrane (TM), and intracellular regions. Nucleotide and amino acid sequences of the extracellular region of P. falciparum SURFIN1.1 from a total of 31 field isolates were obtained and analyzed for genetic polymorphism: six different haplotypes were identified. The extracellular region of the SURFIN1.1 among field isolates was conserved, especially in the cysteine-rich domain (CRD) sub-region. High polymorphism was shown in the variable region 2 (Var2), followed by N-terminal (N-ter) and variable region 1 (Var1), respectively. The findings presented herein may enable the discovery and development of a novel SURFIN-based vaccine for prevention and control of malaria. |
format |
Article in Journal/Newspaper |
author |
Natpasit Chaianantakul Tippawan Sungkapong Jirapinya Changpad Keawalin Thongma Sasiwimon Sim-ut Morakot Kaewthamasorn |
author_facet |
Natpasit Chaianantakul Tippawan Sungkapong Jirapinya Changpad Keawalin Thongma Sasiwimon Sim-ut Morakot Kaewthamasorn |
author_sort |
Natpasit Chaianantakul |
title |
Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand |
title_short |
Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand |
title_full |
Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand |
title_fullStr |
Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand |
title_full_unstemmed |
Genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of Plasmodium falciparum field isolates from Thailand |
title_sort |
genetic polymorphism of the extracellular region in surface associated interspersed 1.1 gene of plasmodium falciparum field isolates from thailand |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12936-021-03876-y https://doaj.org/article/dfe23b4f5f3f462b9fb98e193d766cea |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 20, Iss 1, Pp 1-14 (2021) |
op_relation |
https://doi.org/10.1186/s12936-021-03876-y https://doaj.org/toc/1475-2875 doi:10.1186/s12936-021-03876-y 1475-2875 https://doaj.org/article/dfe23b4f5f3f462b9fb98e193d766cea |
op_doi |
https://doi.org/10.1186/s12936-021-03876-y |
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Malaria Journal |
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20 |
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1766334974991007744 |