Anti-SARS-CoV-2 antibody immunoreactivity profiles during COVID-19 recurrence

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: Maria da Penha Gomes Gouvea, Isac Ribeiro Moulaz, Thayná Martins Gouveia, Karen Evelin Monlevade Lança, Bárbara Sthefany de Paula Lacerda, Beatriz Paoli Thompson, Jéssica Polese, Marina Deorce de Lima, Rodrigo Ribeiro-Rodrigues, José Geraldo Mill, Valéria Valim
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 2022
• Subjects: COVID-19; SARS-CoV-2; Recurrence; Humoral Reactivity; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/0037-8682-0106-2022; https://doaj.org/article/dfcd4aa03830475bab3bfa00545fca26

ABSTRACT Background: This study aimed to evaluate IgG and IgM levels in COVID-19 recurrence. Methods: The serum antibody levels and clinical data from 73 healthcare workers with SARS-CoV-2 divided into seroconverted (n=51) and non-seroconverted (n=22) groups were assessed. The presence of specific anti-nucleocapsid (anti-N) IgM and IgG for SARS-CoV-2 was evaluated. IgG antibodies to the SARS-CoV-2 spike receptor-binding domain were used to confirm non-seroconversion in all negative anti-N. Results: Four recurrent cases displayed mild symptoms and were non-seroconverted until the recurrence of symptoms. Conclusions: Undetectable anti-nucleocapsid IgM and IgG levels may be correlated with symptomatic COVID-19 recurrence.