Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour
Abstract Background Consistent individual differences in behaviour, known as animal personalities, have been demonstrated within and across species. In fish, studies applying an animal personality approach have been used to resolve variation in physiological and molecular data suggesting a linkage,...
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ftdoajarticles:oai:doaj.org/article:dfcd35fd931745bdb338eb65d38f6107 2023-05-15T15:32:56+02:00 Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour Sonia Rey Xingkun Jin Børge Damsgård Marie-Laure Bégout Simon Mackenzie 2021-01-01T00:00:00Z https://doi.org/10.1186/s12864-020-07317-z https://doaj.org/article/dfcd35fd931745bdb338eb65d38f6107 EN eng BMC https://doi.org/10.1186/s12864-020-07317-z https://doaj.org/toc/1471-2164 doi:10.1186/s12864-020-07317-z 1471-2164 https://doaj.org/article/dfcd35fd931745bdb338eb65d38f6107 BMC Genomics, Vol 22, Iss 1, Pp 1-17 (2021) Proactive Animal personality RNA sequencing Fish behaviour Phenotype variation Convergent evolution Biotechnology TP248.13-248.65 Genetics QH426-470 article 2021 ftdoajarticles https://doi.org/10.1186/s12864-020-07317-z 2022-12-31T06:09:50Z Abstract Background Consistent individual differences in behaviour, known as animal personalities, have been demonstrated within and across species. In fish, studies applying an animal personality approach have been used to resolve variation in physiological and molecular data suggesting a linkage, genotype-phenotype, between behaviour and transcriptome regulation. In this study, using three fish species (zebrafish; Danio rerio, Atlantic salmon; Salmo salar and European sea bass; Dicentrarchus labrax), we firstly address whether personality-specific mRNA transcript abundances are transferrable across distantly-related fish species and secondly whether a proactive transcriptome signature is conserved across all three species. Results Previous zebrafish transcriptome data was used as a foundation to produce a curated list of mRNA transcripts related to animal personality across all three species. mRNA transcript copy numbers for selected gene targets show that differential mRNA transcript abundance in the brain appears to be partially conserved across species relative to personality type. Secondly, we performed RNA-Seq using whole brains from S. salar and D. labrax scoring positively for both behavioural and molecular assays for proactive behaviour. We further enriched this dataset by incorporating a zebrafish brain transcriptome dataset specific to the proactive phenotype. Our results indicate that cross-species molecular signatures related to proactive behaviour are functionally conserved where shared functional pathways suggest that evolutionary convergence may be more important than individual mRNAs. Conclusions Our data supports the proposition that highly polygenic clusters of genes, with small additive effects, likely support the underpinning molecular variation related to the animal personalities in the fish used in this study. The polygenic nature of the proactive brain transcriptome across all three species questions the existence of specific molecular signatures for proactive behaviour, at least at the ... Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles BMC Genomics 22 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Proactive Animal personality RNA sequencing Fish behaviour Phenotype variation Convergent evolution Biotechnology TP248.13-248.65 Genetics QH426-470 |
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Proactive Animal personality RNA sequencing Fish behaviour Phenotype variation Convergent evolution Biotechnology TP248.13-248.65 Genetics QH426-470 Sonia Rey Xingkun Jin Børge Damsgård Marie-Laure Bégout Simon Mackenzie Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour |
topic_facet |
Proactive Animal personality RNA sequencing Fish behaviour Phenotype variation Convergent evolution Biotechnology TP248.13-248.65 Genetics QH426-470 |
description |
Abstract Background Consistent individual differences in behaviour, known as animal personalities, have been demonstrated within and across species. In fish, studies applying an animal personality approach have been used to resolve variation in physiological and molecular data suggesting a linkage, genotype-phenotype, between behaviour and transcriptome regulation. In this study, using three fish species (zebrafish; Danio rerio, Atlantic salmon; Salmo salar and European sea bass; Dicentrarchus labrax), we firstly address whether personality-specific mRNA transcript abundances are transferrable across distantly-related fish species and secondly whether a proactive transcriptome signature is conserved across all three species. Results Previous zebrafish transcriptome data was used as a foundation to produce a curated list of mRNA transcripts related to animal personality across all three species. mRNA transcript copy numbers for selected gene targets show that differential mRNA transcript abundance in the brain appears to be partially conserved across species relative to personality type. Secondly, we performed RNA-Seq using whole brains from S. salar and D. labrax scoring positively for both behavioural and molecular assays for proactive behaviour. We further enriched this dataset by incorporating a zebrafish brain transcriptome dataset specific to the proactive phenotype. Our results indicate that cross-species molecular signatures related to proactive behaviour are functionally conserved where shared functional pathways suggest that evolutionary convergence may be more important than individual mRNAs. Conclusions Our data supports the proposition that highly polygenic clusters of genes, with small additive effects, likely support the underpinning molecular variation related to the animal personalities in the fish used in this study. The polygenic nature of the proactive brain transcriptome across all three species questions the existence of specific molecular signatures for proactive behaviour, at least at the ... |
format |
Article in Journal/Newspaper |
author |
Sonia Rey Xingkun Jin Børge Damsgård Marie-Laure Bégout Simon Mackenzie |
author_facet |
Sonia Rey Xingkun Jin Børge Damsgård Marie-Laure Bégout Simon Mackenzie |
author_sort |
Sonia Rey |
title |
Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour |
title_short |
Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour |
title_full |
Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour |
title_fullStr |
Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour |
title_full_unstemmed |
Analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour |
title_sort |
analysis across diverse fish species highlights no conserved transcriptome signature for proactive behaviour |
publisher |
BMC |
publishDate |
2021 |
url |
https://doi.org/10.1186/s12864-020-07317-z https://doaj.org/article/dfcd35fd931745bdb338eb65d38f6107 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
BMC Genomics, Vol 22, Iss 1, Pp 1-17 (2021) |
op_relation |
https://doi.org/10.1186/s12864-020-07317-z https://doaj.org/toc/1471-2164 doi:10.1186/s12864-020-07317-z 1471-2164 https://doaj.org/article/dfcd35fd931745bdb338eb65d38f6107 |
op_doi |
https://doi.org/10.1186/s12864-020-07317-z |
container_title |
BMC Genomics |
container_volume |
22 |
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1 |
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1766363414710452224 |