Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population.
Background Use of hormonal contraceptives has been associated with Staphylococcus aureus nasal carriage in adult women. However, the role of hormonal contraceptives in S. aureus colonization among adolescents and associations with progestin only contraceptives are unknown. Methods We obtained nasal...
Published in: | PLOS ONE |
---|---|
Main Authors: | , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pone.0218511 https://doaj.org/article/ded5a276cc354236acc32e26344df0ac |
id |
ftdoajarticles:oai:doaj.org/article:ded5a276cc354236acc32e26344df0ac |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:ded5a276cc354236acc32e26344df0ac 2023-05-15T18:34:40+02:00 Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. Dina B Stensen Lars Småbrekke Karina Olsen Guri Grimnes Christopher Sivert Nielsen Gunnar Skov Simonsen Johanna U E Sollid Anne-Sofie Furberg 2019-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0218511 https://doaj.org/article/ded5a276cc354236acc32e26344df0ac EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pone.0218511 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0218511 https://doaj.org/article/ded5a276cc354236acc32e26344df0ac PLoS ONE, Vol 14, Iss 7, p e0218511 (2019) Medicine R Science Q article 2019 ftdoajarticles https://doi.org/10.1371/journal.pone.0218511 2022-12-31T07:47:36Z Background Use of hormonal contraceptives has been associated with Staphylococcus aureus nasal carriage in adult women. However, the role of hormonal contraceptives in S. aureus colonization among adolescents and associations with progestin only contraceptives are unknown. Methods We obtained nasal and throat swab samples from 439 girls aged 17-21 years in the population-based Tromsø study Fit Futures, 2012-2013, Norway, with information on lifestyle, health and biomarkers. We used multivariable logistic regression to study the association between use of hormonal contraceptives and Staphylococcus aureus carriage while adjusting for potential confounding factors. Results Staphylococcus aureus nasal carriage prevalence were 34%, 42%, and 61% among progestin-only users, non-users, and progestin-estrogen combination contraceptive users, respectively (P<0.001). Use of combination contraceptives doubled the odds of nasal carriage (non-users reference; OR = 2.31, 95%CI = 1.43-3.74). The OR of nasal carriage was 0.29 among progestin-only users compared to combination contraceptives users (95% CI = 0.12-0.67). Discussion In this study, use of combination hormonal contraceptives was associated with higher risk of Staphylococcus aureus nasal carriage in adolescent girls. Experimental design studies are needed to establish the role of exogenous sex steroids in Staphylococcus aureus colonization in women. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Norway Tromsø PLOS ONE 14 7 e0218511 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Dina B Stensen Lars Småbrekke Karina Olsen Guri Grimnes Christopher Sivert Nielsen Gunnar Skov Simonsen Johanna U E Sollid Anne-Sofie Furberg Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. |
topic_facet |
Medicine R Science Q |
description |
Background Use of hormonal contraceptives has been associated with Staphylococcus aureus nasal carriage in adult women. However, the role of hormonal contraceptives in S. aureus colonization among adolescents and associations with progestin only contraceptives are unknown. Methods We obtained nasal and throat swab samples from 439 girls aged 17-21 years in the population-based Tromsø study Fit Futures, 2012-2013, Norway, with information on lifestyle, health and biomarkers. We used multivariable logistic regression to study the association between use of hormonal contraceptives and Staphylococcus aureus carriage while adjusting for potential confounding factors. Results Staphylococcus aureus nasal carriage prevalence were 34%, 42%, and 61% among progestin-only users, non-users, and progestin-estrogen combination contraceptive users, respectively (P<0.001). Use of combination contraceptives doubled the odds of nasal carriage (non-users reference; OR = 2.31, 95%CI = 1.43-3.74). The OR of nasal carriage was 0.29 among progestin-only users compared to combination contraceptives users (95% CI = 0.12-0.67). Discussion In this study, use of combination hormonal contraceptives was associated with higher risk of Staphylococcus aureus nasal carriage in adolescent girls. Experimental design studies are needed to establish the role of exogenous sex steroids in Staphylococcus aureus colonization in women. |
format |
Article in Journal/Newspaper |
author |
Dina B Stensen Lars Småbrekke Karina Olsen Guri Grimnes Christopher Sivert Nielsen Gunnar Skov Simonsen Johanna U E Sollid Anne-Sofie Furberg |
author_facet |
Dina B Stensen Lars Småbrekke Karina Olsen Guri Grimnes Christopher Sivert Nielsen Gunnar Skov Simonsen Johanna U E Sollid Anne-Sofie Furberg |
author_sort |
Dina B Stensen |
title |
Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. |
title_short |
Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. |
title_full |
Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. |
title_fullStr |
Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. |
title_full_unstemmed |
Hormonal contraceptive use and Staphylococcus aureus nasal and throat carriage in a Norwegian youth population. |
title_sort |
hormonal contraceptive use and staphylococcus aureus nasal and throat carriage in a norwegian youth population. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pone.0218511 https://doaj.org/article/ded5a276cc354236acc32e26344df0ac |
geographic |
Norway Tromsø |
geographic_facet |
Norway Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
PLoS ONE, Vol 14, Iss 7, p e0218511 (2019) |
op_relation |
https://doi.org/10.1371/journal.pone.0218511 https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0218511 https://doaj.org/article/ded5a276cc354236acc32e26344df0ac |
op_doi |
https://doi.org/10.1371/journal.pone.0218511 |
container_title |
PLOS ONE |
container_volume |
14 |
container_issue |
7 |
container_start_page |
e0218511 |
_version_ |
1766219530595467264 |