Study of anticardiolipin antibody in hepatitis C virus-positive patients
Several antibodies, including anticardiolipin antibodies (ACA), have been detected among chronically infected hepatitis C virus (HCV) patients. The present work aimed at ascertaining the clinical significance of ACA levels among HCV infection associated with two commonly encountered diseases, thromb...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:de9b404e682344dfb32b25d882d411c1 2023-05-15T15:11:09+02:00 Study of anticardiolipin antibody in hepatitis C virus-positive patients H Elsayeh N Abdallah NA Hamed MG Morsi A Eldighidy HA Kamal 2011-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992011000400014 https://doaj.org/article/de9b404e682344dfb32b25d882d411c1 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400014 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000400014 1678-9199 https://doaj.org/article/de9b404e682344dfb32b25d882d411c1 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 4, Pp 467-472 (2011) hepatitis C virus hemodialysis anticardiolipin antibody enzyme-linked immunosorbent assay Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2011 ftdoajarticles https://doi.org/10.1590/S1678-91992011000400014 2022-12-31T05:09:30Z Several antibodies, including anticardiolipin antibodies (ACA), have been detected among chronically infected hepatitis C virus (HCV) patients. The present work aimed at ascertaining the clinical significance of ACA levels among HCV infection associated with two commonly encountered diseases, thrombocytopenia and arteriovenous-shunt malfunction. Six groups were studied, 11 HCV-positive thrombocytopenic patients (group I), 14 HCV-positive non-thrombocytopenic patients (group II) and 15 healthy controls (group III), 11 anti-HCV-positive hemodialysis patients with non-functioning shunt (group IV), 14 anti-HCV-positive hemodialysis patients with patent shunt (group V) (Bain Medical Equipment Co., China) and 15 healthy controls (group VI). Anticardiolipin antibody (ACA) assay was performed on all patients and controls whereas tumor necrosis factor α (TNF-α) assay was carried out on thrombocytopenic patients and controls. Thrombocytopenic groups presented an inverse correlation between IgG ACA levels and both thrombocytopenia and TNF-α levels. During the follow-up period, no other clinical manifestations related to ACA were developed. Hemodialysis groups showed a significant elevation in IgG ACA levels in groups IV and V compared to the controls, with statistically higher levels in group IV than group V. Three group IV patients were hypercholesterolemic. We can conclude that induction of proinflammatory cytokines such as TNF-α by persistent HCV infection may promote the generation of ACA. Complications of HCV, including thrombocytopenia and thrombosis in arteriovenous shunt, are more strongly correlated with IgG ACA than with IgM ACA. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Bain ENVELOPE(-65.433,-65.433,-66.550,-66.550) Journal of Venomous Animals and Toxins including Tropical Diseases 17 4 467 472 |
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Directory of Open Access Journals: DOAJ Articles |
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topic |
hepatitis C virus hemodialysis anticardiolipin antibody enzyme-linked immunosorbent assay Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
hepatitis C virus hemodialysis anticardiolipin antibody enzyme-linked immunosorbent assay Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 H Elsayeh N Abdallah NA Hamed MG Morsi A Eldighidy HA Kamal Study of anticardiolipin antibody in hepatitis C virus-positive patients |
topic_facet |
hepatitis C virus hemodialysis anticardiolipin antibody enzyme-linked immunosorbent assay Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Several antibodies, including anticardiolipin antibodies (ACA), have been detected among chronically infected hepatitis C virus (HCV) patients. The present work aimed at ascertaining the clinical significance of ACA levels among HCV infection associated with two commonly encountered diseases, thrombocytopenia and arteriovenous-shunt malfunction. Six groups were studied, 11 HCV-positive thrombocytopenic patients (group I), 14 HCV-positive non-thrombocytopenic patients (group II) and 15 healthy controls (group III), 11 anti-HCV-positive hemodialysis patients with non-functioning shunt (group IV), 14 anti-HCV-positive hemodialysis patients with patent shunt (group V) (Bain Medical Equipment Co., China) and 15 healthy controls (group VI). Anticardiolipin antibody (ACA) assay was performed on all patients and controls whereas tumor necrosis factor α (TNF-α) assay was carried out on thrombocytopenic patients and controls. Thrombocytopenic groups presented an inverse correlation between IgG ACA levels and both thrombocytopenia and TNF-α levels. During the follow-up period, no other clinical manifestations related to ACA were developed. Hemodialysis groups showed a significant elevation in IgG ACA levels in groups IV and V compared to the controls, with statistically higher levels in group IV than group V. Three group IV patients were hypercholesterolemic. We can conclude that induction of proinflammatory cytokines such as TNF-α by persistent HCV infection may promote the generation of ACA. Complications of HCV, including thrombocytopenia and thrombosis in arteriovenous shunt, are more strongly correlated with IgG ACA than with IgM ACA. |
format |
Article in Journal/Newspaper |
author |
H Elsayeh N Abdallah NA Hamed MG Morsi A Eldighidy HA Kamal |
author_facet |
H Elsayeh N Abdallah NA Hamed MG Morsi A Eldighidy HA Kamal |
author_sort |
H Elsayeh |
title |
Study of anticardiolipin antibody in hepatitis C virus-positive patients |
title_short |
Study of anticardiolipin antibody in hepatitis C virus-positive patients |
title_full |
Study of anticardiolipin antibody in hepatitis C virus-positive patients |
title_fullStr |
Study of anticardiolipin antibody in hepatitis C virus-positive patients |
title_full_unstemmed |
Study of anticardiolipin antibody in hepatitis C virus-positive patients |
title_sort |
study of anticardiolipin antibody in hepatitis c virus-positive patients |
publisher |
SciELO |
publishDate |
2011 |
url |
https://doi.org/10.1590/S1678-91992011000400014 https://doaj.org/article/de9b404e682344dfb32b25d882d411c1 |
long_lat |
ENVELOPE(-65.433,-65.433,-66.550,-66.550) |
geographic |
Arctic Bain |
geographic_facet |
Arctic Bain |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 17, Iss 4, Pp 467-472 (2011) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000400014 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992011000400014 1678-9199 https://doaj.org/article/de9b404e682344dfb32b25d882d411c1 |
op_doi |
https://doi.org/10.1590/S1678-91992011000400014 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
17 |
container_issue |
4 |
container_start_page |
467 |
op_container_end_page |
472 |
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