Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project
Background . The Aklavik H. pylori Project (AHPP) (www.canhelpworkinggroup.ca) is a community-driven project examining Helicobacter pylori infection and its influence on health in a diverse Aboriginal community in the Northwest Territories. Initial research revealed that 58% of 333 participants who...
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Taylor & Francis Group
2013
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ftdoajarticles:oai:doaj.org/article:de33a2cfd4374bd5a6634b73a7cf9927 2023-05-15T13:07:59+02:00 Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project Sally Carraher Hsiu-Ju Chang Rachel Munday Karen J. Goodman the CANHelp Working Group 2013-08-01T00:00:00Z https://doi.org/10.3402/ijch.v72i0.21594 https://doaj.org/article/de33a2cfd4374bd5a6634b73a7cf9927 EN eng Taylor & Francis Group http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/21594/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.21594 2242-3982 https://doaj.org/article/de33a2cfd4374bd5a6634b73a7cf9927 International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-7 (2013) Helicobacter pylori infection Aboriginal health collaborative research epidemiology incidence Arctic Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles https://doi.org/10.3402/ijch.v72i0.21594 2022-12-31T11:55:48Z Background . The Aklavik H. pylori Project (AHPP) (www.canhelpworkinggroup.ca) is a community-driven project examining Helicobacter pylori infection and its influence on health in a diverse Aboriginal community in the Northwest Territories. Initial research revealed that 58% of 333 participants who underwent a urea breath test (UBT) between 2007 and 2010 were H. pylori-positive. From 2008 to 2010, we offered treatment to H. pylori-positive participants and 113 consented to this treatment. Objective . We estimated H. pylori incidence in AHPP participants who initially tested negative and the re-infection frequency in initially positive participants who were successfully treated to clear the infection. Methods . Participants who were initially H. pylori-negative or negative after treatment during 2008–2010 were eligible for inclusion. From November 2011 to June 2012, participants were offered a UBT and the samples were analyzed using infrared spectroscopy (IRIS). Participants with a positive test result were classified as new cases for estimating incidence among participants testing negative at baseline and re-infection among those successfully treated for H. pylori infection. Results. Among 38 initially negative participants, follow-up UBT showed that 33 remained negative, 3 were positive, and 2 had uncertain status. The estimated incidence proportion during the follow-up period was 8.3% (95% CI: 1.8–22.0%). Among 43 participants with a negative post-treatment UBT, 41 remained negative and 2 were positive. The estimated re-infection proportion during the follow-up period was 4.7% (95% CI: 0.6–16.0%). The frequency of new cases was similar in males and females. Aboriginal participants had a combined re-infection/incidence rate of 2.4% per year (95% CI: 0.8–5.9% per year). All 9 non-Aboriginal participants remained free from infection throughout the study period, as did all 23 participants aged 55 years and above. Conclusions . The AHPP has substantially reduced the ... Article in Journal/Newspaper Aklavik Arctic Circumpolar Health International Journal of Circumpolar Health Northwest Territories Directory of Open Access Journals: DOAJ Articles Aklavik ENVELOPE(-135.011,-135.011,68.219,68.219) Arctic Northwest Territories International Journal of Circumpolar Health 72 1 21594 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Helicobacter pylori infection Aboriginal health collaborative research epidemiology incidence Arctic Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Helicobacter pylori infection Aboriginal health collaborative research epidemiology incidence Arctic Arctic medicine. Tropical medicine RC955-962 Sally Carraher Hsiu-Ju Chang Rachel Munday Karen J. Goodman the CANHelp Working Group Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
topic_facet |
Helicobacter pylori infection Aboriginal health collaborative research epidemiology incidence Arctic Arctic medicine. Tropical medicine RC955-962 |
description |
Background . The Aklavik H. pylori Project (AHPP) (www.canhelpworkinggroup.ca) is a community-driven project examining Helicobacter pylori infection and its influence on health in a diverse Aboriginal community in the Northwest Territories. Initial research revealed that 58% of 333 participants who underwent a urea breath test (UBT) between 2007 and 2010 were H. pylori-positive. From 2008 to 2010, we offered treatment to H. pylori-positive participants and 113 consented to this treatment. Objective . We estimated H. pylori incidence in AHPP participants who initially tested negative and the re-infection frequency in initially positive participants who were successfully treated to clear the infection. Methods . Participants who were initially H. pylori-negative or negative after treatment during 2008–2010 were eligible for inclusion. From November 2011 to June 2012, participants were offered a UBT and the samples were analyzed using infrared spectroscopy (IRIS). Participants with a positive test result were classified as new cases for estimating incidence among participants testing negative at baseline and re-infection among those successfully treated for H. pylori infection. Results. Among 38 initially negative participants, follow-up UBT showed that 33 remained negative, 3 were positive, and 2 had uncertain status. The estimated incidence proportion during the follow-up period was 8.3% (95% CI: 1.8–22.0%). Among 43 participants with a negative post-treatment UBT, 41 remained negative and 2 were positive. The estimated re-infection proportion during the follow-up period was 4.7% (95% CI: 0.6–16.0%). The frequency of new cases was similar in males and females. Aboriginal participants had a combined re-infection/incidence rate of 2.4% per year (95% CI: 0.8–5.9% per year). All 9 non-Aboriginal participants remained free from infection throughout the study period, as did all 23 participants aged 55 years and above. Conclusions . The AHPP has substantially reduced the ... |
format |
Article in Journal/Newspaper |
author |
Sally Carraher Hsiu-Ju Chang Rachel Munday Karen J. Goodman the CANHelp Working Group |
author_facet |
Sally Carraher Hsiu-Ju Chang Rachel Munday Karen J. Goodman the CANHelp Working Group |
author_sort |
Sally Carraher |
title |
Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
title_short |
Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
title_full |
Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
title_fullStr |
Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
title_full_unstemmed |
Helicobacter pylori incidence and re-infection in the Aklavik H. pylori Project |
title_sort |
helicobacter pylori incidence and re-infection in the aklavik h. pylori project |
publisher |
Taylor & Francis Group |
publishDate |
2013 |
url |
https://doi.org/10.3402/ijch.v72i0.21594 https://doaj.org/article/de33a2cfd4374bd5a6634b73a7cf9927 |
long_lat |
ENVELOPE(-135.011,-135.011,68.219,68.219) |
geographic |
Aklavik Arctic Northwest Territories |
geographic_facet |
Aklavik Arctic Northwest Territories |
genre |
Aklavik Arctic Circumpolar Health International Journal of Circumpolar Health Northwest Territories |
genre_facet |
Aklavik Arctic Circumpolar Health International Journal of Circumpolar Health Northwest Territories |
op_source |
International Journal of Circumpolar Health, Vol 72, Iss 0, Pp 1-7 (2013) |
op_relation |
http://www.circumpolarhealthjournal.net/index.php/ijch/article/download/21594/pdf_1 https://doaj.org/toc/2242-3982 doi:10.3402/ijch.v72i0.21594 2242-3982 https://doaj.org/article/de33a2cfd4374bd5a6634b73a7cf9927 |
op_doi |
https://doi.org/10.3402/ijch.v72i0.21594 |
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International Journal of Circumpolar Health |
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72 |
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1 |
container_start_page |
21594 |
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1766071115407425536 |