Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats
Objective: To evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos (CPF) and cypermethrin (CYP)-evoked cognitive changes in male Wistar rats. Methods: Fifty adult male Wistar rats, divided into five groups of ten rats each, were used for the study. Groups 1 and II were given dis...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:de1999834267461194402d617e00f5f5 2023-05-15T15:07:03+02:00 Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats Idris Sherifat Banke Ambali Suleiman Folorunsho Bisalla Mohammed Suleiman Mohammed Musa Onukak Charles Ayo Joseph Olusegun 2014-04-01T00:00:00Z https://doi.org/10.12980/APJTB.4.2014C55 https://doaj.org/article/de1999834267461194402d617e00f5f5 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115302136 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C55 https://doaj.org/article/de1999834267461194402d617e00f5f5 Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 4, Pp 318-323 (2014) Chlorpyrifos Cypermethrin Cognition Brain malondialdehyde Melatonin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.12980/APJTB.4.2014C55 2022-12-30T23:09:00Z Objective: To evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos (CPF) and cypermethrin (CYP)-evoked cognitive changes in male Wistar rats. Methods: Fifty adult male Wistar rats, divided into five groups of ten rats each, were used for the study. Groups 1 and II were given distilled water and soya oil (2 mL/kg) respectively. Group III was administered with melatonin at 0.5 mg/kg only. Group IV was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)], and Group V was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)] 30 min after melatonin (0.5 mg/kg). The regimens were administered by gavage once daily for 12 weeks. Thereafter, cognitive performances were determined and the brain was evaluated for malonaldehyde concentration. Results: CPF and CYP induced cognitive deficits and increased brain malonaldehyde concentration, which were all ameliorated by melatonin. Conclusion: Cognitive deficits elicited by CPF and CYP was mitigated by melatonin due to its antioxidant property. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 4 318 323 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Chlorpyrifos Cypermethrin Cognition Brain malondialdehyde Melatonin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Chlorpyrifos Cypermethrin Cognition Brain malondialdehyde Melatonin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Idris Sherifat Banke Ambali Suleiman Folorunsho Bisalla Mohammed Suleiman Mohammed Musa Onukak Charles Ayo Joseph Olusegun Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats |
topic_facet |
Chlorpyrifos Cypermethrin Cognition Brain malondialdehyde Melatonin Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To evaluate the ameliorative effect of melatonin on sub-chronic chlorpyrifos (CPF) and cypermethrin (CYP)-evoked cognitive changes in male Wistar rats. Methods: Fifty adult male Wistar rats, divided into five groups of ten rats each, were used for the study. Groups 1 and II were given distilled water and soya oil (2 mL/kg) respectively. Group III was administered with melatonin at 0.5 mg/kg only. Group IV was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)], and Group V was administered with CPF [7.96 mg/kg (1/10th LD50)] and CYP [29.6 mg/kg (1/10th LD50)] 30 min after melatonin (0.5 mg/kg). The regimens were administered by gavage once daily for 12 weeks. Thereafter, cognitive performances were determined and the brain was evaluated for malonaldehyde concentration. Results: CPF and CYP induced cognitive deficits and increased brain malonaldehyde concentration, which were all ameliorated by melatonin. Conclusion: Cognitive deficits elicited by CPF and CYP was mitigated by melatonin due to its antioxidant property. |
format |
Article in Journal/Newspaper |
author |
Idris Sherifat Banke Ambali Suleiman Folorunsho Bisalla Mohammed Suleiman Mohammed Musa Onukak Charles Ayo Joseph Olusegun |
author_facet |
Idris Sherifat Banke Ambali Suleiman Folorunsho Bisalla Mohammed Suleiman Mohammed Musa Onukak Charles Ayo Joseph Olusegun |
author_sort |
Idris Sherifat Banke |
title |
Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats |
title_short |
Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats |
title_full |
Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats |
title_fullStr |
Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats |
title_full_unstemmed |
Effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male Wister rats |
title_sort |
effects of melatonin on changes in cognitive performances and brain malondialdehyde concentration induced by sub–chronic co–administration of chlorpyrifos and cypermethrin in male wister rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.12980/APJTB.4.2014C55 https://doaj.org/article/de1999834267461194402d617e00f5f5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 4, Pp 318-323 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115302136 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.2014C55 https://doaj.org/article/de1999834267461194402d617e00f5f5 |
op_doi |
https://doi.org/10.12980/APJTB.4.2014C55 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_issue |
4 |
container_start_page |
318 |
op_container_end_page |
323 |
_version_ |
1766338628582113280 |