Effects of Yeast Species and Processing on Intestinal Health and Transcriptomic Profiles of Atlantic Salmon ( Salmo salar ) Fed Soybean Meal-Based Diets in Seawater
The objective of the current study was to examine the effects of yeasts on intestinal health and transcriptomic profiles from the distal intestine and spleen tissue of Atlantic salmon fed SBM-based diets in seawater. Cyberlindnera jadinii (CJ) and Wickerhamomyces anomalus (WA) yeasts were heat-inact...
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ftdoajarticles:oai:doaj.org/article:ddf344522be54554a0f527c693291f40 2023-05-15T15:30:55+02:00 Effects of Yeast Species and Processing on Intestinal Health and Transcriptomic Profiles of Atlantic Salmon ( Salmo salar ) Fed Soybean Meal-Based Diets in Seawater Jeleel O. Agboola Dominic D. Mensah Jon Ø. Hansen David Lapeña Liv T. Mydland Magnus Ø. Arntzen Svein J. Horn Ove Øyås Charles McL. Press Margareth Øverland 2022-01-01T00:00:00Z https://doi.org/10.3390/ijms23031675 https://doaj.org/article/ddf344522be54554a0f527c693291f40 EN eng MDPI AG https://www.mdpi.com/1422-0067/23/3/1675 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms23031675 1422-0067 1661-6596 https://doaj.org/article/ddf344522be54554a0f527c693291f40 International Journal of Molecular Sciences, Vol 23, Iss 1675, p 1675 (2022) Cyberlindnera jadinii Wickerhamomyces anomalus intestinal health SBMIE transcriptomics distal intestine Biology (General) QH301-705.5 Chemistry QD1-999 article 2022 ftdoajarticles https://doi.org/10.3390/ijms23031675 2022-12-31T10:41:01Z The objective of the current study was to examine the effects of yeasts on intestinal health and transcriptomic profiles from the distal intestine and spleen tissue of Atlantic salmon fed SBM-based diets in seawater. Cyberlindnera jadinii (CJ) and Wickerhamomyces anomalus (WA) yeasts were heat-inactivated with spray-drying (ICJ and IWA) or autolyzed at 50 °C for 16 h (ACJ and AWA), followed by spray-drying. Six diets were formulated, one based on fishmeal (FM), a challenging diet with 30% soybean meal (SBM) and four other diets containing 30% SBM and 10% of each of the four yeast fractions (i.e., ICJ, ACJ, IWA and AWA). The inclusion of CJ yeasts reduced the loss of enterocyte supranuclear vacuolization and reduced the population of CD8α labeled cells present in the lamina propria of fish fed the SBM diet. The CJ yeasts controlled the inflammatory responses of fish fed SBM through up-regulation of pathways related to wound healing and taurine metabolism. The WA yeasts dampened the inflammatory profile of fish fed SBM through down-regulation of pathways related to toll-like receptor signaling, C-lectin receptor, cytokine receptor and signal transduction. This study suggests that the yeast species, Cyberlindnera jadinii and Wickerhamomyces anomalus are novel high-quality protein sources with health-beneficial effects in terms of reducing inflammation associated with feeding plant-based diets to Atlantic salmon. Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles International Journal of Molecular Sciences 23 3 1675 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Cyberlindnera jadinii Wickerhamomyces anomalus intestinal health SBMIE transcriptomics distal intestine Biology (General) QH301-705.5 Chemistry QD1-999 |
spellingShingle |
Cyberlindnera jadinii Wickerhamomyces anomalus intestinal health SBMIE transcriptomics distal intestine Biology (General) QH301-705.5 Chemistry QD1-999 Jeleel O. Agboola Dominic D. Mensah Jon Ø. Hansen David Lapeña Liv T. Mydland Magnus Ø. Arntzen Svein J. Horn Ove Øyås Charles McL. Press Margareth Øverland Effects of Yeast Species and Processing on Intestinal Health and Transcriptomic Profiles of Atlantic Salmon ( Salmo salar ) Fed Soybean Meal-Based Diets in Seawater |
topic_facet |
Cyberlindnera jadinii Wickerhamomyces anomalus intestinal health SBMIE transcriptomics distal intestine Biology (General) QH301-705.5 Chemistry QD1-999 |
description |
The objective of the current study was to examine the effects of yeasts on intestinal health and transcriptomic profiles from the distal intestine and spleen tissue of Atlantic salmon fed SBM-based diets in seawater. Cyberlindnera jadinii (CJ) and Wickerhamomyces anomalus (WA) yeasts were heat-inactivated with spray-drying (ICJ and IWA) or autolyzed at 50 °C for 16 h (ACJ and AWA), followed by spray-drying. Six diets were formulated, one based on fishmeal (FM), a challenging diet with 30% soybean meal (SBM) and four other diets containing 30% SBM and 10% of each of the four yeast fractions (i.e., ICJ, ACJ, IWA and AWA). The inclusion of CJ yeasts reduced the loss of enterocyte supranuclear vacuolization and reduced the population of CD8α labeled cells present in the lamina propria of fish fed the SBM diet. The CJ yeasts controlled the inflammatory responses of fish fed SBM through up-regulation of pathways related to wound healing and taurine metabolism. The WA yeasts dampened the inflammatory profile of fish fed SBM through down-regulation of pathways related to toll-like receptor signaling, C-lectin receptor, cytokine receptor and signal transduction. This study suggests that the yeast species, Cyberlindnera jadinii and Wickerhamomyces anomalus are novel high-quality protein sources with health-beneficial effects in terms of reducing inflammation associated with feeding plant-based diets to Atlantic salmon. |
format |
Article in Journal/Newspaper |
author |
Jeleel O. Agboola Dominic D. Mensah Jon Ø. Hansen David Lapeña Liv T. Mydland Magnus Ø. Arntzen Svein J. Horn Ove Øyås Charles McL. Press Margareth Øverland |
author_facet |
Jeleel O. Agboola Dominic D. Mensah Jon Ø. Hansen David Lapeña Liv T. Mydland Magnus Ø. Arntzen Svein J. Horn Ove Øyås Charles McL. Press Margareth Øverland |
author_sort |
Jeleel O. Agboola |
title |
Effects of Yeast Species and Processing on Intestinal Health and Transcriptomic Profiles of Atlantic Salmon ( Salmo salar ) Fed Soybean Meal-Based Diets in Seawater |
title_short |
Effects of Yeast Species and Processing on Intestinal Health and Transcriptomic Profiles of Atlantic Salmon ( Salmo salar ) Fed Soybean Meal-Based Diets in Seawater |
title_full |
Effects of Yeast Species and Processing on Intestinal Health and Transcriptomic Profiles of Atlantic Salmon ( Salmo salar ) Fed Soybean Meal-Based Diets in Seawater |
title_fullStr |
Effects of Yeast Species and Processing on Intestinal Health and Transcriptomic Profiles of Atlantic Salmon ( Salmo salar ) Fed Soybean Meal-Based Diets in Seawater |
title_full_unstemmed |
Effects of Yeast Species and Processing on Intestinal Health and Transcriptomic Profiles of Atlantic Salmon ( Salmo salar ) Fed Soybean Meal-Based Diets in Seawater |
title_sort |
effects of yeast species and processing on intestinal health and transcriptomic profiles of atlantic salmon ( salmo salar ) fed soybean meal-based diets in seawater |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/ijms23031675 https://doaj.org/article/ddf344522be54554a0f527c693291f40 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
International Journal of Molecular Sciences, Vol 23, Iss 1675, p 1675 (2022) |
op_relation |
https://www.mdpi.com/1422-0067/23/3/1675 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms23031675 1422-0067 1661-6596 https://doaj.org/article/ddf344522be54554a0f527c693291f40 |
op_doi |
https://doi.org/10.3390/ijms23031675 |
container_title |
International Journal of Molecular Sciences |
container_volume |
23 |
container_issue |
3 |
container_start_page |
1675 |
_version_ |
1766361399154442240 |