Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique.
A randomized controlled field trial to evaluate the effectiveness of a single oral dose of 30 mg/kg of oxfendazole (OFZ) treatment for control of porcine cysticercosis was conducted in 4 rural villages of Angónia district, north-western Mozambique. Two hundred and sixteen piglets aged 4 months were...
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ftdoajarticles:oai:doaj.org/article:ddce2d02381749d795362acd76764253 2023-05-15T15:15:58+02:00 Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique. Alberto Pondja Luís Neves James Mlangwa Sónia Afonso José Fafetine Arve Lee Willingham Stig Milan Thamsborg Maria Vang Johansen 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001651 https://doaj.org/article/ddce2d02381749d795362acd76764253 EN eng Public Library of Science (PLoS) https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22666509/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001651 https://doaj.org/article/ddce2d02381749d795362acd76764253 PLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1651 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001651 2022-12-31T05:46:01Z A randomized controlled field trial to evaluate the effectiveness of a single oral dose of 30 mg/kg of oxfendazole (OFZ) treatment for control of porcine cysticercosis was conducted in 4 rural villages of Angónia district, north-western Mozambique. Two hundred and sixteen piglets aged 4 months were selected and assigned randomly to OFZ treatment or control groups. Fifty-four piglets were treated at 4 months of age (T1), while another 54 piglets were treated at 9 months of age (T2) and these were matched with 108 control pigs from the same litters and raised under the same conditions. Baseline data were collected on the prevalence of porcine cysticercosis using antigen ELISA (Ag-ELISA), as well as knowledge and practices related to Taenia solium transmission based on questionnaire interviews and observations. All animals were followed and re-tested for porcine cysticercosis by Ag-ELISA at 9 and 12 months of age when the study was terminated. Overall prevalence at baseline was 5.1% with no significant difference between groups. At the end of the study, 66.7% of the controls were found positive, whereas 21.4% of the T1 and 9.1% of the T2 pigs were positive, respectively. Incidence rates of porcine cysticercosis were lower in treated pigs as compared to controls. Necropsy of 30 randomly selected animals revealed that viable cysts were present in none (0/8) of T2 pigs, 12.5% (1/8) of T1 pigs and 42.8% (6/14) of control pigs. There was a significant reduction in the risk of T. solium cysticercosis if pigs were treated with OFZ either at 4 months (OR = 0.14; 95% CI: 0.05-0.36) or at 9 months of age (OR = 0.05; 95% CI: 0.02-0.16). Strategic treatment of pigs in endemic areas should be further explored as a means to control T. solium cysticercosis/taeniosis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 5 e1651 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Alberto Pondja Luís Neves James Mlangwa Sónia Afonso José Fafetine Arve Lee Willingham Stig Milan Thamsborg Maria Vang Johansen Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
A randomized controlled field trial to evaluate the effectiveness of a single oral dose of 30 mg/kg of oxfendazole (OFZ) treatment for control of porcine cysticercosis was conducted in 4 rural villages of Angónia district, north-western Mozambique. Two hundred and sixteen piglets aged 4 months were selected and assigned randomly to OFZ treatment or control groups. Fifty-four piglets were treated at 4 months of age (T1), while another 54 piglets were treated at 9 months of age (T2) and these were matched with 108 control pigs from the same litters and raised under the same conditions. Baseline data were collected on the prevalence of porcine cysticercosis using antigen ELISA (Ag-ELISA), as well as knowledge and practices related to Taenia solium transmission based on questionnaire interviews and observations. All animals were followed and re-tested for porcine cysticercosis by Ag-ELISA at 9 and 12 months of age when the study was terminated. Overall prevalence at baseline was 5.1% with no significant difference between groups. At the end of the study, 66.7% of the controls were found positive, whereas 21.4% of the T1 and 9.1% of the T2 pigs were positive, respectively. Incidence rates of porcine cysticercosis were lower in treated pigs as compared to controls. Necropsy of 30 randomly selected animals revealed that viable cysts were present in none (0/8) of T2 pigs, 12.5% (1/8) of T1 pigs and 42.8% (6/14) of control pigs. There was a significant reduction in the risk of T. solium cysticercosis if pigs were treated with OFZ either at 4 months (OR = 0.14; 95% CI: 0.05-0.36) or at 9 months of age (OR = 0.05; 95% CI: 0.02-0.16). Strategic treatment of pigs in endemic areas should be further explored as a means to control T. solium cysticercosis/taeniosis. |
format |
Article in Journal/Newspaper |
author |
Alberto Pondja Luís Neves James Mlangwa Sónia Afonso José Fafetine Arve Lee Willingham Stig Milan Thamsborg Maria Vang Johansen |
author_facet |
Alberto Pondja Luís Neves James Mlangwa Sónia Afonso José Fafetine Arve Lee Willingham Stig Milan Thamsborg Maria Vang Johansen |
author_sort |
Alberto Pondja |
title |
Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique. |
title_short |
Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique. |
title_full |
Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique. |
title_fullStr |
Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique. |
title_full_unstemmed |
Use of oxfendazole to control porcine cysticercosis in a high-endemic area of Mozambique. |
title_sort |
use of oxfendazole to control porcine cysticercosis in a high-endemic area of mozambique. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001651 https://doaj.org/article/ddce2d02381749d795362acd76764253 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1651 (2012) |
op_relation |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22666509/?tool=EBI https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001651 https://doaj.org/article/ddce2d02381749d795362acd76764253 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001651 |
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PLoS Neglected Tropical Diseases |
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6 |
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5 |
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e1651 |
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