Kinetics of the cercaria-schistosomul um transformation in vivo: 2. The effect of oxamniquine

• Published in: Revista da Sociedade Brasileira de Medicina Tropical
• Main Authors: A. L. Melo, L.H. Pereira
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1985
• Subjects: Schistosoma mansoni Cercária; Esquistossômulo; Transformação in vivo; Oxamniquine; Arctic medicine. Tropical medicine; RC955-962; Arctic
• Online Access: https://doi.org/10.1590/S0037-86821985000400008; https://doaj.org/article/ddcd1968489b423481910649db9a1bea

To study the cercaria-schistosomulum transformation in vivo, underthe influence of an antischistosomal compound (oxamniquine), a model using cercarial infections into the abdominal cavity of mice was chosen. This procedure provided easy and reproducible recoveries of larvae from peritoneal washings with appropriate solutions for a long time (30 to 180 min) after inoculation. The results show that high doses of oxamniquine (given intramuscularly one hour before the infection) produce a marked delay in the kinetics of the cercaria-schistosomulum transformation. Cercariae, tail-less cercarial bodies and schistosomula were recovered from the peritoneal cavity ofdrug treated mice in numbers significantly different from those recovered from untreated mice.