Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya
Abstract Background It has been hypothesized that the African alleles Sl2 and McC b of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated. M...
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ftdoajarticles:oai:doaj.org/article:ddace73fa03143a5bd02468633afb09d 2023-05-15T15:08:44+02:00 Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya Otieno Walter Guyah Bernard Moulds JoAnn M Thathy Vandana Stoute José A 2005-11-01T00:00:00Z https://doi.org/10.1186/1475-2875-4-54 https://doaj.org/article/ddace73fa03143a5bd02468633afb09d EN eng BMC http://www.malariajournal.com/content/4/1/54 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-4-54 1475-2875 https://doaj.org/article/ddace73fa03143a5bd02468633afb09d Malaria Journal, Vol 4, Iss 1, p 54 (2005) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2005 ftdoajarticles https://doi.org/10.1186/1475-2875-4-54 2022-12-31T02:59:06Z Abstract Background It has been hypothesized that the African alleles Sl2 and McC b of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated. Methods To test this hypothesis, children in western Kenya with severe malaria-associated anaemia or cerebral malaria were matched to symptomatic uncomplicated malaria controls by age and gender. Swain-Langley and McCoy blood group alleles were determined by restriction fragment length polymorphism and conditional logistic regression was carried out. Results No significant association was found between the African alleles and severe malaria-associated anaemia. However, children with Sl2/2 genotype were less likely to have cerebral malaria (OR = 0.17, 95% CI 0.04 to 0.72, P = 0.02) than children with Sl1/1 . In particular, individuals with Sl2/2 McC a/b genotype were less likely to have cerebral malaria (OR = 0.18, 95% CI 0.04 to 0.77, P = 0.02) than individuals with Sl1/1 McC a/a . Conclusion These results support the hypothesis that the Sl2 allele and, possibly, the McC b allele evolved in the context of malaria transmission and that in certain combinations probably confer a survival advantage on these populations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic McCoy ENVELOPE(-140.533,-140.533,-75.883,-75.883) Malaria Journal 4 1 54 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Otieno Walter Guyah Bernard Moulds JoAnn M Thathy Vandana Stoute José A Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background It has been hypothesized that the African alleles Sl2 and McC b of the Swain-Langley (Sl) and McCoy (McC) blood group antigens of the complement receptor 1 (CR1) may confer a survival advantage in the setting of Plasmodium falciparum malaria, but this has not been demonstrated. Methods To test this hypothesis, children in western Kenya with severe malaria-associated anaemia or cerebral malaria were matched to symptomatic uncomplicated malaria controls by age and gender. Swain-Langley and McCoy blood group alleles were determined by restriction fragment length polymorphism and conditional logistic regression was carried out. Results No significant association was found between the African alleles and severe malaria-associated anaemia. However, children with Sl2/2 genotype were less likely to have cerebral malaria (OR = 0.17, 95% CI 0.04 to 0.72, P = 0.02) than children with Sl1/1 . In particular, individuals with Sl2/2 McC a/b genotype were less likely to have cerebral malaria (OR = 0.18, 95% CI 0.04 to 0.77, P = 0.02) than individuals with Sl1/1 McC a/a . Conclusion These results support the hypothesis that the Sl2 allele and, possibly, the McC b allele evolved in the context of malaria transmission and that in certain combinations probably confer a survival advantage on these populations. |
format |
Article in Journal/Newspaper |
author |
Otieno Walter Guyah Bernard Moulds JoAnn M Thathy Vandana Stoute José A |
author_facet |
Otieno Walter Guyah Bernard Moulds JoAnn M Thathy Vandana Stoute José A |
author_sort |
Otieno Walter |
title |
Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya |
title_short |
Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya |
title_full |
Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya |
title_fullStr |
Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya |
title_full_unstemmed |
Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya |
title_sort |
complement receptor 1 polymorphisms associated with resistance to severe malaria in kenya |
publisher |
BMC |
publishDate |
2005 |
url |
https://doi.org/10.1186/1475-2875-4-54 https://doaj.org/article/ddace73fa03143a5bd02468633afb09d |
long_lat |
ENVELOPE(-140.533,-140.533,-75.883,-75.883) |
geographic |
Arctic McCoy |
geographic_facet |
Arctic McCoy |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 4, Iss 1, p 54 (2005) |
op_relation |
http://www.malariajournal.com/content/4/1/54 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-4-54 1475-2875 https://doaj.org/article/ddace73fa03143a5bd02468633afb09d |
op_doi |
https://doi.org/10.1186/1475-2875-4-54 |
container_title |
Malaria Journal |
container_volume |
4 |
container_issue |
1 |
container_start_page |
54 |
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1766340036393959424 |