Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?
Snakebite envenoming is a major public health burden in tropical parts of the developing world. In sub-Saharan Africa, neglect has led to a scarcity of antivenoms threatening the lives and limbs of snakebite victims. Technological advances within antivenom are warranted, but should be evaluated not...
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ftdoajarticles:oai:doaj.org/article:dd237e67f47b4d76a9b98ac61d9010cc 2023-05-15T15:05:37+02:00 Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease? Andreas H Laustsen Kristoffer H Johansen Mikael Engmark Mikael R Andersen 2017-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005361 https://doaj.org/article/dd237e67f47b4d76a9b98ac61d9010cc EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5310919?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005361 https://doaj.org/article/dd237e67f47b4d76a9b98ac61d9010cc PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005361 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005361 2022-12-31T11:51:44Z Snakebite envenoming is a major public health burden in tropical parts of the developing world. In sub-Saharan Africa, neglect has led to a scarcity of antivenoms threatening the lives and limbs of snakebite victims. Technological advances within antivenom are warranted, but should be evaluated not only on their possible therapeutic impact, but also on their cost-competitiveness. Recombinant antivenoms based on oligoclonal mixtures of human IgG antibodies produced by CHO cell cultivation may be the key to obtaining better snakebite envenoming therapies. Based on industry data, the cost of treatment for a snakebite envenoming with a recombinant antivenom is estimated to be in the range USD 60-250 for the Final Drug Product. One of the effective antivenoms (SAIMR Snake Polyvalent Antivenom from the South African Vaccine Producers) currently on the market has been reported to have a wholesale price of USD 640 per treatment for an average snakebite. Recombinant antivenoms may therefore in the future be a cost-competitive alternative to existing serum-based antivenoms. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 2 e0005361 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Andreas H Laustsen Kristoffer H Johansen Mikael Engmark Mikael R Andersen Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease? |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Snakebite envenoming is a major public health burden in tropical parts of the developing world. In sub-Saharan Africa, neglect has led to a scarcity of antivenoms threatening the lives and limbs of snakebite victims. Technological advances within antivenom are warranted, but should be evaluated not only on their possible therapeutic impact, but also on their cost-competitiveness. Recombinant antivenoms based on oligoclonal mixtures of human IgG antibodies produced by CHO cell cultivation may be the key to obtaining better snakebite envenoming therapies. Based on industry data, the cost of treatment for a snakebite envenoming with a recombinant antivenom is estimated to be in the range USD 60-250 for the Final Drug Product. One of the effective antivenoms (SAIMR Snake Polyvalent Antivenom from the South African Vaccine Producers) currently on the market has been reported to have a wholesale price of USD 640 per treatment for an average snakebite. Recombinant antivenoms may therefore in the future be a cost-competitive alternative to existing serum-based antivenoms. |
format |
Article in Journal/Newspaper |
author |
Andreas H Laustsen Kristoffer H Johansen Mikael Engmark Mikael R Andersen |
author_facet |
Andreas H Laustsen Kristoffer H Johansen Mikael Engmark Mikael R Andersen |
author_sort |
Andreas H Laustsen |
title |
Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease? |
title_short |
Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease? |
title_full |
Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease? |
title_fullStr |
Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease? |
title_full_unstemmed |
Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease? |
title_sort |
recombinant snakebite antivenoms: a cost-competitive solution to a neglected tropical disease? |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005361 https://doaj.org/article/dd237e67f47b4d76a9b98ac61d9010cc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 2, p e0005361 (2017) |
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http://europepmc.org/articles/PMC5310919?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005361 https://doaj.org/article/dd237e67f47b4d76a9b98ac61d9010cc |
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https://doi.org/10.1371/journal.pntd.0005361 |
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PLOS Neglected Tropical Diseases |
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11 |
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2 |
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e0005361 |
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