Scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis
The objective of this paper was to evaluate the hepatobiliary function of patients with pulmonary tuberculosis under triple treatment, using the technetium-99m-DISIDA (99mTc-DISIDA) hepatobiliary scintigraphy. Ten men and three women with pulmonary tuberculosis were subjected to hepatobiliary scinti...
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ftdoajarticles:oai:doaj.org/article:dd0091a9f02e4902976ef34699490a3a 2023-05-15T15:09:02+02:00 Scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis R. S. A. Camargo E. T. Silva B. L. Griva P. C. M. Pereira 2006-04-01T00:00:00Z https://doi.org/10.1590/S1678-91992006000200006 https://doaj.org/article/dd0091a9f02e4902976ef34699490a3a EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200006 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000200006 1678-9199 https://doaj.org/article/dd0091a9f02e4902976ef34699490a3a Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 2, Pp 234-244 (2006) pulmonar tuberculosis scintigraphy hepatobiliar system antituberculosis drugs Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2006 ftdoajarticles https://doi.org/10.1590/S1678-91992006000200006 2022-12-31T14:53:32Z The objective of this paper was to evaluate the hepatobiliary function of patients with pulmonary tuberculosis under triple treatment, using the technetium-99m-DISIDA (99mTc-DISIDA) hepatobiliary scintigraphy. Ten men and three women with pulmonary tuberculosis were subjected to hepatobiliary scintigraphy at the beginning of triple treatment (M1) and two months after it (M2). Patients were from the urban area, of low socioeconomic level, malnourished, and chronic alcohol and/or tobacco users. Ten normal individuals were evaluated as controls. Radiotracer images were acquired on a computerized gamma camera (Orbiter-Siemens) and T1/2 uptake and excretion values were calculated. Nutritional status and serum hepatic enzyme levels for each patient were evaluated at M1 and M2. None presented clinical or laboratory antecedent of hepatobiliary disease. At M1, there were no hepatic serum or kinetic alterations of the 99mTc-DISIDA. At M2, patients presented better nutritional conditions than at M1; there was increased serum aspartate aminotransferase (AST) and reduced excretion time for 99mTc-DISIDA, which was interpreted as a more adaptive than toxic phenomenon, yet not all alterations were significant and none manifested clinically. Apparently, triple treatment acted on the liver inducing the P450 cytochrome enzymatic system, accelerating radiotracer excretion, which follows the same path as the bilirubins. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 12 2 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
pulmonar tuberculosis scintigraphy hepatobiliar system antituberculosis drugs Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
pulmonar tuberculosis scintigraphy hepatobiliar system antituberculosis drugs Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 R. S. A. Camargo E. T. Silva B. L. Griva P. C. M. Pereira Scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis |
topic_facet |
pulmonar tuberculosis scintigraphy hepatobiliar system antituberculosis drugs Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The objective of this paper was to evaluate the hepatobiliary function of patients with pulmonary tuberculosis under triple treatment, using the technetium-99m-DISIDA (99mTc-DISIDA) hepatobiliary scintigraphy. Ten men and three women with pulmonary tuberculosis were subjected to hepatobiliary scintigraphy at the beginning of triple treatment (M1) and two months after it (M2). Patients were from the urban area, of low socioeconomic level, malnourished, and chronic alcohol and/or tobacco users. Ten normal individuals were evaluated as controls. Radiotracer images were acquired on a computerized gamma camera (Orbiter-Siemens) and T1/2 uptake and excretion values were calculated. Nutritional status and serum hepatic enzyme levels for each patient were evaluated at M1 and M2. None presented clinical or laboratory antecedent of hepatobiliary disease. At M1, there were no hepatic serum or kinetic alterations of the 99mTc-DISIDA. At M2, patients presented better nutritional conditions than at M1; there was increased serum aspartate aminotransferase (AST) and reduced excretion time for 99mTc-DISIDA, which was interpreted as a more adaptive than toxic phenomenon, yet not all alterations were significant and none manifested clinically. Apparently, triple treatment acted on the liver inducing the P450 cytochrome enzymatic system, accelerating radiotracer excretion, which follows the same path as the bilirubins. |
format |
Article in Journal/Newspaper |
author |
R. S. A. Camargo E. T. Silva B. L. Griva P. C. M. Pereira |
author_facet |
R. S. A. Camargo E. T. Silva B. L. Griva P. C. M. Pereira |
author_sort |
R. S. A. Camargo |
title |
Scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis |
title_short |
Scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis |
title_full |
Scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis |
title_fullStr |
Scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis |
title_full_unstemmed |
Scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis |
title_sort |
scintigraphy of the hepatobiliar system in patients with pulmonary tuberculosis |
publisher |
SciELO |
publishDate |
2006 |
url |
https://doi.org/10.1590/S1678-91992006000200006 https://doaj.org/article/dd0091a9f02e4902976ef34699490a3a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 2, Pp 234-244 (2006) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000200006 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000200006 1678-9199 https://doaj.org/article/dd0091a9f02e4902976ef34699490a3a |
op_doi |
https://doi.org/10.1590/S1678-91992006000200006 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
12 |
container_issue |
2 |
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1766340278502817792 |