Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea.
Human African trypanosomiasis (HAT), a lethal disease induced by Trypanosoma brucei gambiense, has a range of clinical outcomes in its human host in West Africa: an acute form progressing rapidly to second stage, spontaneous self-cure and individuals able to regulate parasitaemia at very low levels,...
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Online Access: | https://doi.org/10.1371/journal.pntd.0005833 https://doaj.org/article/dcf1f227b1c947b7bcfecbda74ff60c7 |
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ftdoajarticles:oai:doaj.org/article:dcf1f227b1c947b7bcfecbda74ff60c7 2023-05-15T15:16:31+02:00 Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. Justin Windingoudi Kaboré Hamidou Ilboudo Harry Noyes Oumou Camara Jacques Kaboré Mamadou Camara Mathurin Koffi Veerle Lejon Vincent Jamonneau Annette MacLeod Christiane Hertz-Fowler Adrien Marie Gaston Belem Enock Matovu Bruno Bucheton Issa Sidibe TrypanoGEN Research Group as members of The H3Africa Consortium 2017-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005833 https://doaj.org/article/dcf1f227b1c947b7bcfecbda74ff60c7 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5595334?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005833 https://doaj.org/article/dcf1f227b1c947b7bcfecbda74ff60c7 PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005833 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005833 2022-12-31T13:27:19Z Human African trypanosomiasis (HAT), a lethal disease induced by Trypanosoma brucei gambiense, has a range of clinical outcomes in its human host in West Africa: an acute form progressing rapidly to second stage, spontaneous self-cure and individuals able to regulate parasitaemia at very low levels, have all been reported from endemic foci. In order to test if this clinical diversity is influenced by host genetic determinants, the association between candidate gene polymorphisms and HAT outcome was investigated in populations from HAT active foci in Guinea.Samples were collected from 425 individuals; comprising of 232 HAT cases, 79 subjects with long lasting positive and specific serology but negative parasitology and 114 endemic controls. Genotypes of 28 SNPs in eight genes passed quality control and were used for an association analysis. IL6 rs1818879 allele A (p = 0.0001, OR = 0.39, CI95 = [0.24-0.63], BONF = 0.0034) was associated with a lower risk of progressing from latent infection to active disease. MIF rs36086171 allele G seemed to be associated with an increased risk (p = 0.0239, OR = 1.65, CI95 = [1.07-2.53], BONF = 0.6697) but did not remain significant after Bonferroni correction. Similarly MIF rs12483859 C allele seems be associated with latent infections (p = 0.0077, OR = 1.86, CI95 = [1.18-2.95], BONF = 0.2157). We confirmed earlier observations that APOL1 G2 allele (DEL) (p = 0.0011, OR = 2.70, CI95 = [1.49-4.91], BONF = 0.0301) is associated with a higher risk and APOL1 G1 polymorphism (p = 0.0005, OR = 0.45, CI95 = [0.29-0.70], BONF = 0.0129) with a lower risk of developing HAT. No associations were found with other candidate genes.Our data show that host genes are involved in modulating Trypanosoma brucei gambiense infection outcome in infected individuals from Guinea with IL6 rs1818879 being associated with a lower risk of progressing to active HAT. These results enhance our understanding of host-parasite interactions and, ultimately, may lead to the development of new control tools. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 8 e0005833 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Justin Windingoudi Kaboré Hamidou Ilboudo Harry Noyes Oumou Camara Jacques Kaboré Mamadou Camara Mathurin Koffi Veerle Lejon Vincent Jamonneau Annette MacLeod Christiane Hertz-Fowler Adrien Marie Gaston Belem Enock Matovu Bruno Bucheton Issa Sidibe TrypanoGEN Research Group as members of The H3Africa Consortium Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Human African trypanosomiasis (HAT), a lethal disease induced by Trypanosoma brucei gambiense, has a range of clinical outcomes in its human host in West Africa: an acute form progressing rapidly to second stage, spontaneous self-cure and individuals able to regulate parasitaemia at very low levels, have all been reported from endemic foci. In order to test if this clinical diversity is influenced by host genetic determinants, the association between candidate gene polymorphisms and HAT outcome was investigated in populations from HAT active foci in Guinea.Samples were collected from 425 individuals; comprising of 232 HAT cases, 79 subjects with long lasting positive and specific serology but negative parasitology and 114 endemic controls. Genotypes of 28 SNPs in eight genes passed quality control and were used for an association analysis. IL6 rs1818879 allele A (p = 0.0001, OR = 0.39, CI95 = [0.24-0.63], BONF = 0.0034) was associated with a lower risk of progressing from latent infection to active disease. MIF rs36086171 allele G seemed to be associated with an increased risk (p = 0.0239, OR = 1.65, CI95 = [1.07-2.53], BONF = 0.6697) but did not remain significant after Bonferroni correction. Similarly MIF rs12483859 C allele seems be associated with latent infections (p = 0.0077, OR = 1.86, CI95 = [1.18-2.95], BONF = 0.2157). We confirmed earlier observations that APOL1 G2 allele (DEL) (p = 0.0011, OR = 2.70, CI95 = [1.49-4.91], BONF = 0.0301) is associated with a higher risk and APOL1 G1 polymorphism (p = 0.0005, OR = 0.45, CI95 = [0.29-0.70], BONF = 0.0129) with a lower risk of developing HAT. No associations were found with other candidate genes.Our data show that host genes are involved in modulating Trypanosoma brucei gambiense infection outcome in infected individuals from Guinea with IL6 rs1818879 being associated with a lower risk of progressing to active HAT. These results enhance our understanding of host-parasite interactions and, ultimately, may lead to the development of new control tools. |
format |
Article in Journal/Newspaper |
author |
Justin Windingoudi Kaboré Hamidou Ilboudo Harry Noyes Oumou Camara Jacques Kaboré Mamadou Camara Mathurin Koffi Veerle Lejon Vincent Jamonneau Annette MacLeod Christiane Hertz-Fowler Adrien Marie Gaston Belem Enock Matovu Bruno Bucheton Issa Sidibe TrypanoGEN Research Group as members of The H3Africa Consortium |
author_facet |
Justin Windingoudi Kaboré Hamidou Ilboudo Harry Noyes Oumou Camara Jacques Kaboré Mamadou Camara Mathurin Koffi Veerle Lejon Vincent Jamonneau Annette MacLeod Christiane Hertz-Fowler Adrien Marie Gaston Belem Enock Matovu Bruno Bucheton Issa Sidibe TrypanoGEN Research Group as members of The H3Africa Consortium |
author_sort |
Justin Windingoudi Kaboré |
title |
Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. |
title_short |
Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. |
title_full |
Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. |
title_fullStr |
Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. |
title_full_unstemmed |
Candidate gene polymorphisms study between human African trypanosomiasis clinical phenotypes in Guinea. |
title_sort |
candidate gene polymorphisms study between human african trypanosomiasis clinical phenotypes in guinea. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005833 https://doaj.org/article/dcf1f227b1c947b7bcfecbda74ff60c7 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 8, p e0005833 (2017) |
op_relation |
http://europepmc.org/articles/PMC5595334?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005833 https://doaj.org/article/dcf1f227b1c947b7bcfecbda74ff60c7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005833 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
8 |
container_start_page |
e0005833 |
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1766346815730352128 |