Defining symptoms of malaria in India in an era of asymptomatic infections
Abstract Background Malaria is a major public health problem in India. Data from surveys totaling 3031 participants at three sites revealed a high proportion of asymptomatic infections, complicating diagnosis. The aim of this study was to identify differences in complaints and symptoms between sites...
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ftdoajarticles:oai:doaj.org/article:dc6ebe0123044c0fbd44975585dd3a89 2023-05-15T15:16:09+02:00 Defining symptoms of malaria in India in an era of asymptomatic infections Anna Maria van Eijk Asad S. Mannan Steven A. Sullivan Jane M. Carlton 2020-07-01T00:00:00Z https://doi.org/10.1186/s12936-020-03310-9 https://doaj.org/article/dc6ebe0123044c0fbd44975585dd3a89 EN eng BMC http://link.springer.com/article/10.1186/s12936-020-03310-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03310-9 1475-2875 https://doaj.org/article/dc6ebe0123044c0fbd44975585dd3a89 Malaria Journal, Vol 19, Iss 1, Pp 1-11 (2020) Malaria Urban Rural Asymptomatic infection Microscopy PCR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-03310-9 2022-12-31T04:05:47Z Abstract Background Malaria is a major public health problem in India. Data from surveys totaling 3031 participants at three sites revealed a high proportion of asymptomatic infections, complicating diagnosis. The aim of this study was to identify differences in complaints and symptoms between sites, and factors associated with asymptomatic Plasmodium infections. Methods Published data from community-based cross-sectional studies conducted between 2012 and 2015 in Nadiad (Gujarat), Chennai (Tamil Nadu), and Rourkela (Odisha) as part of the Center for the Study of Complex Malaria in India were analysed. Complaints and symptoms were systematically recorded, and Plasmodium infections confirmed using microscopy, rapid diagnostic tests (RDTs), and polymerase chain reaction (PCR). Multivariate analyses were conducted to determine the association between general symptoms and age, season, or gender, and factors associated with asymptomatic Plasmodium infections were assessed. Results Complaints of any illness were lowest in Chennai (17.7%), 30.6% in Rourkela and 42.7% in Nadiad. Complaints were more often reported for children; gender differences were noted in Rourkela only. In Nadiad, 7.0% of 796 participants were positive for malaria by PCR (32% Plasmodium falciparum); 78.6% had a history of fever or documented fever, 14.3% had other symptoms, and 7.1% were “truly asymptomatic”. For Chennai this was 29.2%, 4.2% and 66.7% respectively, with a malaria prevalence of 2.6% by PCR of 928 participants (29% P. falciparum). In Rourkela, with 7.7% of 1307 participants positive for malaria by PCR (82% P. falciparum), the percentages were 35.6%, 24.8% and 39.6%, respectively. In Rourkela, asymptomatic infections were associated with young age and male gender (microscopy or RDT), and with rainy season (PCR). In the same site, participants with Plasmodium vivax were more likely to be asymptomatic (11/18 or 61.1%) than persons with P. falciparum mono-infections (27/78 or 34.6%); gametocytes for P. falciparum were evenly distributed ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 19 1 |
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Malaria Urban Rural Asymptomatic infection Microscopy PCR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Urban Rural Asymptomatic infection Microscopy PCR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Anna Maria van Eijk Asad S. Mannan Steven A. Sullivan Jane M. Carlton Defining symptoms of malaria in India in an era of asymptomatic infections |
topic_facet |
Malaria Urban Rural Asymptomatic infection Microscopy PCR Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria is a major public health problem in India. Data from surveys totaling 3031 participants at three sites revealed a high proportion of asymptomatic infections, complicating diagnosis. The aim of this study was to identify differences in complaints and symptoms between sites, and factors associated with asymptomatic Plasmodium infections. Methods Published data from community-based cross-sectional studies conducted between 2012 and 2015 in Nadiad (Gujarat), Chennai (Tamil Nadu), and Rourkela (Odisha) as part of the Center for the Study of Complex Malaria in India were analysed. Complaints and symptoms were systematically recorded, and Plasmodium infections confirmed using microscopy, rapid diagnostic tests (RDTs), and polymerase chain reaction (PCR). Multivariate analyses were conducted to determine the association between general symptoms and age, season, or gender, and factors associated with asymptomatic Plasmodium infections were assessed. Results Complaints of any illness were lowest in Chennai (17.7%), 30.6% in Rourkela and 42.7% in Nadiad. Complaints were more often reported for children; gender differences were noted in Rourkela only. In Nadiad, 7.0% of 796 participants were positive for malaria by PCR (32% Plasmodium falciparum); 78.6% had a history of fever or documented fever, 14.3% had other symptoms, and 7.1% were “truly asymptomatic”. For Chennai this was 29.2%, 4.2% and 66.7% respectively, with a malaria prevalence of 2.6% by PCR of 928 participants (29% P. falciparum). In Rourkela, with 7.7% of 1307 participants positive for malaria by PCR (82% P. falciparum), the percentages were 35.6%, 24.8% and 39.6%, respectively. In Rourkela, asymptomatic infections were associated with young age and male gender (microscopy or RDT), and with rainy season (PCR). In the same site, participants with Plasmodium vivax were more likely to be asymptomatic (11/18 or 61.1%) than persons with P. falciparum mono-infections (27/78 or 34.6%); gametocytes for P. falciparum were evenly distributed ... |
format |
Article in Journal/Newspaper |
author |
Anna Maria van Eijk Asad S. Mannan Steven A. Sullivan Jane M. Carlton |
author_facet |
Anna Maria van Eijk Asad S. Mannan Steven A. Sullivan Jane M. Carlton |
author_sort |
Anna Maria van Eijk |
title |
Defining symptoms of malaria in India in an era of asymptomatic infections |
title_short |
Defining symptoms of malaria in India in an era of asymptomatic infections |
title_full |
Defining symptoms of malaria in India in an era of asymptomatic infections |
title_fullStr |
Defining symptoms of malaria in India in an era of asymptomatic infections |
title_full_unstemmed |
Defining symptoms of malaria in India in an era of asymptomatic infections |
title_sort |
defining symptoms of malaria in india in an era of asymptomatic infections |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-03310-9 https://doaj.org/article/dc6ebe0123044c0fbd44975585dd3a89 |
geographic |
Arctic |
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Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-11 (2020) |
op_relation |
http://link.springer.com/article/10.1186/s12936-020-03310-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-03310-9 1475-2875 https://doaj.org/article/dc6ebe0123044c0fbd44975585dd3a89 |
op_doi |
https://doi.org/10.1186/s12936-020-03310-9 |
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Malaria Journal |
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19 |
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1 |
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1766346449730142208 |