Investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children.
In 2012, the World Health Organisation (WHO) set out a roadmap for eliminating schistosomiasis as a public health problem by 2025. To achieve this target, preschool-aged children (PSAC; aged 6 years and below) will need to be included in schistosomiasis treatment programmes. As the global community...
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ftdoajarticles:oai:doaj.org/article:dc4f9f10b5b34b05890662d06317947c 2023-05-15T15:16:43+02:00 Investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children. Rivka M Lim Mark E J Woolhouse Takafira Mduluza Margo Chase-Topping Derick N M Osakunor Lester Chitsulo Francisca Mutapi 2020-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008650 https://doaj.org/article/dc4f9f10b5b34b05890662d06317947c EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008650 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008650 https://doaj.org/article/dc4f9f10b5b34b05890662d06317947c PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008650 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008650 2022-12-31T05:04:46Z In 2012, the World Health Organisation (WHO) set out a roadmap for eliminating schistosomiasis as a public health problem by 2025. To achieve this target, preschool-aged children (PSAC; aged 6 years and below) will need to be included in schistosomiasis treatment programmes. As the global community discusses the tools and approaches for treating this group, one of the main questions that remains unanswered is how to quantify infection in this age group to inform treatment strategies. The aim of this study was thus to determine whether a relationship exists between levels of schistosome infection in PSAC and school-aged children (SAC), that can be used to determine unknown schistosome infection prevalence levels in PSAC. A systematic search of publications reporting schistosomiasis prevalence in African PSAC and SAC was conducted. The search strategy was formulated using the PRISMA guidelines and SPIDER search strategy tool. The published data was subjected to regression analysis to determine if a relationship exists between infection levels in PSAC and SAC. The interaction between SAC and community treatment history was also entered in the regression model to determine if treatment history significantly affected the relationship between PSAC and SAC prevalence. The results showed that a significant positive relationship exists between infection prevalence levels in PSAC and SAC for Schistosoma mansoni (r = 0.812, df (88, 1), p = <0.0001) and S. haematobium (r = 0.786, df (53, 1), p = <0.0001). The relationship was still significant after allowing for diagnostic method, treatment history, and the African sub-region where the study was conducted (S. mansoni: F = 25.63, df (88, 9), p = <0.0001; S. haematobium: F = 10.20, df (53, 10), p = <0.0001). Using the regression equation for PSAC and SAC prevalence, over 90% of the PSAC prevalence studies were placed in the correct WHO classifications category based on the SAC levels, regardless of treatment history. The study indicated that schistosome prevalence ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Prisma ENVELOPE(-58.767,-58.767,-69.200,-69.200) PLOS Neglected Tropical Diseases 14 10 e0008650 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Rivka M Lim Mark E J Woolhouse Takafira Mduluza Margo Chase-Topping Derick N M Osakunor Lester Chitsulo Francisca Mutapi Investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In 2012, the World Health Organisation (WHO) set out a roadmap for eliminating schistosomiasis as a public health problem by 2025. To achieve this target, preschool-aged children (PSAC; aged 6 years and below) will need to be included in schistosomiasis treatment programmes. As the global community discusses the tools and approaches for treating this group, one of the main questions that remains unanswered is how to quantify infection in this age group to inform treatment strategies. The aim of this study was thus to determine whether a relationship exists between levels of schistosome infection in PSAC and school-aged children (SAC), that can be used to determine unknown schistosome infection prevalence levels in PSAC. A systematic search of publications reporting schistosomiasis prevalence in African PSAC and SAC was conducted. The search strategy was formulated using the PRISMA guidelines and SPIDER search strategy tool. The published data was subjected to regression analysis to determine if a relationship exists between infection levels in PSAC and SAC. The interaction between SAC and community treatment history was also entered in the regression model to determine if treatment history significantly affected the relationship between PSAC and SAC prevalence. The results showed that a significant positive relationship exists between infection prevalence levels in PSAC and SAC for Schistosoma mansoni (r = 0.812, df (88, 1), p = <0.0001) and S. haematobium (r = 0.786, df (53, 1), p = <0.0001). The relationship was still significant after allowing for diagnostic method, treatment history, and the African sub-region where the study was conducted (S. mansoni: F = 25.63, df (88, 9), p = <0.0001; S. haematobium: F = 10.20, df (53, 10), p = <0.0001). Using the regression equation for PSAC and SAC prevalence, over 90% of the PSAC prevalence studies were placed in the correct WHO classifications category based on the SAC levels, regardless of treatment history. The study indicated that schistosome prevalence ... |
format |
Article in Journal/Newspaper |
author |
Rivka M Lim Mark E J Woolhouse Takafira Mduluza Margo Chase-Topping Derick N M Osakunor Lester Chitsulo Francisca Mutapi |
author_facet |
Rivka M Lim Mark E J Woolhouse Takafira Mduluza Margo Chase-Topping Derick N M Osakunor Lester Chitsulo Francisca Mutapi |
author_sort |
Rivka M Lim |
title |
Investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children. |
title_short |
Investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children. |
title_full |
Investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children. |
title_fullStr |
Investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children. |
title_full_unstemmed |
Investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children. |
title_sort |
investigating a strategy for quantifying schistosome infection levels in preschool-aged children using prevalence data from school-aged children. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008650 https://doaj.org/article/dc4f9f10b5b34b05890662d06317947c |
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ENVELOPE(-58.767,-58.767,-69.200,-69.200) |
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Arctic Prisma |
geographic_facet |
Arctic Prisma |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008650 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008650 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008650 https://doaj.org/article/dc4f9f10b5b34b05890662d06317947c |
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https://doi.org/10.1371/journal.pntd.0008650 |
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PLOS Neglected Tropical Diseases |
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