Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogs.
BACKGROUND:Schistosoma japonicum, which remains a major public health problem in the Philippines and mainland China, is the only schistosome species for which zoonotic transmission is considered important. While bovines are suspected as the main zoonotic reservoir in parts of China, the relative con...
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ftdoajarticles:oai:doaj.org/article:dc357f1bc7e640e0b30474bc0babbb0c 2023-05-15T15:10:06+02:00 Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogs. James W Rudge Hélène Carabin Ernesto Balolong Veronica Tallo Jaya Shrivastava Da-Bing Lu María-Gloria Basáñez Remigio Olveda Stephen T McGarvey Joanne P Webster 2008-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000340 https://doaj.org/article/dc357f1bc7e640e0b30474bc0babbb0c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2582952?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000340 https://doaj.org/article/dc357f1bc7e640e0b30474bc0babbb0c PLoS Neglected Tropical Diseases, Vol 2, Iss 11, p e340 (2008) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2008 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000340 2022-12-31T13:26:34Z BACKGROUND:Schistosoma japonicum, which remains a major public health problem in the Philippines and mainland China, is the only schistosome species for which zoonotic transmission is considered important. While bovines are suspected as the main zoonotic reservoir in parts of China, the relative contributions of various non-human mammals to S. japonicum transmission in the Philippines remain to be determined. We examined the population genetics of S. japonicum in the Philippines in order to elucidate transmission patterns across host species and geographic areas. METHODOLOGY/PRINCIPAL FINDINGS:S. japonicum miracidia (hatched from eggs within fecal samples) from humans, dogs, pigs and rats, and cercariae shed from snail-intermediate hosts, were collected across two geographic areas of Samar Province. Individual isolates were then genotyped using seven multiplexed microsatellite loci. Wright's F(ST) values and phylogenetic trees calculated for parasite populations suggest a high frequency of parasite gene-flow across definitive host species, particularly between dogs and humans. Parasite genetic differentiation between areas was not evident at the definitive host level, possibly suggesting frequent import and export of infections between villages, although there was some evidence of geographic structuring at the snail-intermediate host level. CONCLUSIONS/SIGNIFICANCE:These results suggest very high levels of transmission across host species, and indicate that the role of dogs should be considered when planning control programs. Furthermore, a regional approach to treatment programs is recommended where human migration is extensive. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 2 11 e340 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 James W Rudge Hélène Carabin Ernesto Balolong Veronica Tallo Jaya Shrivastava Da-Bing Lu María-Gloria Basáñez Remigio Olveda Stephen T McGarvey Joanne P Webster Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogs. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Schistosoma japonicum, which remains a major public health problem in the Philippines and mainland China, is the only schistosome species for which zoonotic transmission is considered important. While bovines are suspected as the main zoonotic reservoir in parts of China, the relative contributions of various non-human mammals to S. japonicum transmission in the Philippines remain to be determined. We examined the population genetics of S. japonicum in the Philippines in order to elucidate transmission patterns across host species and geographic areas. METHODOLOGY/PRINCIPAL FINDINGS:S. japonicum miracidia (hatched from eggs within fecal samples) from humans, dogs, pigs and rats, and cercariae shed from snail-intermediate hosts, were collected across two geographic areas of Samar Province. Individual isolates were then genotyped using seven multiplexed microsatellite loci. Wright's F(ST) values and phylogenetic trees calculated for parasite populations suggest a high frequency of parasite gene-flow across definitive host species, particularly between dogs and humans. Parasite genetic differentiation between areas was not evident at the definitive host level, possibly suggesting frequent import and export of infections between villages, although there was some evidence of geographic structuring at the snail-intermediate host level. CONCLUSIONS/SIGNIFICANCE:These results suggest very high levels of transmission across host species, and indicate that the role of dogs should be considered when planning control programs. Furthermore, a regional approach to treatment programs is recommended where human migration is extensive. |
format |
Article in Journal/Newspaper |
author |
James W Rudge Hélène Carabin Ernesto Balolong Veronica Tallo Jaya Shrivastava Da-Bing Lu María-Gloria Basáñez Remigio Olveda Stephen T McGarvey Joanne P Webster |
author_facet |
James W Rudge Hélène Carabin Ernesto Balolong Veronica Tallo Jaya Shrivastava Da-Bing Lu María-Gloria Basáñez Remigio Olveda Stephen T McGarvey Joanne P Webster |
author_sort |
James W Rudge |
title |
Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogs. |
title_short |
Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogs. |
title_full |
Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogs. |
title_fullStr |
Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogs. |
title_full_unstemmed |
Population genetics of Schistosoma japonicum within the Philippines suggest high levels of transmission between humans and dogs. |
title_sort |
population genetics of schistosoma japonicum within the philippines suggest high levels of transmission between humans and dogs. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2008 |
url |
https://doi.org/10.1371/journal.pntd.0000340 https://doaj.org/article/dc357f1bc7e640e0b30474bc0babbb0c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 2, Iss 11, p e340 (2008) |
op_relation |
http://europepmc.org/articles/PMC2582952?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000340 https://doaj.org/article/dc357f1bc7e640e0b30474bc0babbb0c |
op_doi |
https://doi.org/10.1371/journal.pntd.0000340 |
container_title |
PLoS Neglected Tropical Diseases |
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2 |
container_issue |
11 |
container_start_page |
e340 |
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1766341159951532032 |