Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection Schistosoma mansoni: avaliação da atividade da oxamniquina (Mansil*) em esquistossômulos com 24 horas após infecção
Mice transcutaneously infected with about 400 cercariae were submitted to treatment with oxamniquine (400 mg/kg), 24 hours after infection. The recovery of schistosomules, at 4, 24, 48 and 72 hours and 35 days after treatment, showed the activity of the drug on the parasites, thus practically preven...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
---|---|
Main Authors: | , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Universidade de São Paulo (USP)
1993
|
Subjects: | |
Online Access: | https://doi.org/10.1590/S0036-46651993000600013 https://doaj.org/article/dc10ee885ffb4747aeedc3dc3dfc8bdd |
id |
ftdoajarticles:oai:doaj.org/article:dc10ee885ffb4747aeedc3dc3dfc8bdd |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:dc10ee885ffb4747aeedc3dc3dfc8bdd 2024-09-09T19:28:24+00:00 Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection Schistosoma mansoni: avaliação da atividade da oxamniquina (Mansil*) em esquistossômulos com 24 horas após infecção Paulo Marcos Zech Coelho Rômulo Teixeira de Mello Silvia Elizabeth Gerken 1993-12-01T00:00:00Z https://doi.org/10.1590/S0036-46651993000600013 https://doaj.org/article/dc10ee885ffb4747aeedc3dc3dfc8bdd EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651993000600013 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651993000600013 0036-4665 1678-9946 https://doaj.org/article/dc10ee885ffb4747aeedc3dc3dfc8bdd Revista do Instituto de Medicina Tropical de São Paulo, Vol 35, Iss 6, Pp 557-561 (1993) Schistosoma mansoni Oxamniquine Schistosomules Migration Chemotherapeutic treatment Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 1993 ftdoajarticles https://doi.org/10.1590/S0036-46651993000600013 2024-08-05T17:49:30Z Mice transcutaneously infected with about 400 cercariae were submitted to treatment with oxamniquine (400 mg/kg), 24 hours after infection. The recovery of schistosomules, at 4, 24, 48 and 72 hours and 35 days after treatment, showed the activity of the drug on the parasites, thus practically preventing their migration from the skin to the lungs. Worm recovery performed in the lungs (96 hours after treatment) showed recovery means of 0.6 worms/mouse in the treated group and 53.8 in the control group (untreated). The perfusion of the portal system carried out at 35 days after treatment clearly showed the elimination of all the parasites in the treated group, whereas a recovery mean of 144.7 worms/mouse was detected in the control group (untreated). These findings confirm the efficacy of oxamniquine at the skin phase of infection, and also show similarity with the immunization method that uses irradiated cercariae. The practical application of these findings in the medical clinic is discussed too Camundongos infectados transcutaneamente com cerca de 400 cercárias foram submetidos a tratamento com oxamniquina (400 mg/kg), 24 horas após a infecção. A recuperação dos esquistossômulos a nível da pele mostrou a atividade da droga nos parasitos e impediu praticamente sua migração para os pulmões. A recuperação a nível pulmonar (96 horas após tratamento) mostrou uma média de 0,6 vermes por camundongo no grupo tratado e 53,8 no grupo controle, não tratado. A perfusão do sistema porta, realizada aos 35 dias após infecção, mostrou claramente a eliminação de todos os parasitos no grupo tratado, enquanto foi recuperada uma média de 144,7 vermes no grupo controle, não tratado. Estes achados vem comprovar a eficácia da oxamniquina na fase cutânea da infecção e mostra analogia com o sistema de imunização que usa cercárias irradiadas. Também se discute a aplicação destes resultados na clínica Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Droga ENVELOPE(6.521,6.521,62.644,62.644) The Portal ENVELOPE(159.167,159.167,-78.100,-78.100) Revista do Instituto de Medicina Tropical de São Paulo 35 6 557 561 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Schistosoma mansoni Oxamniquine Schistosomules Migration Chemotherapeutic treatment Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Schistosoma mansoni Oxamniquine Schistosomules Migration Chemotherapeutic treatment Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Paulo Marcos Zech Coelho Rômulo Teixeira de Mello Silvia Elizabeth Gerken Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection Schistosoma mansoni: avaliação da atividade da oxamniquina (Mansil*) em esquistossômulos com 24 horas após infecção |
topic_facet |
Schistosoma mansoni Oxamniquine Schistosomules Migration Chemotherapeutic treatment Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Mice transcutaneously infected with about 400 cercariae were submitted to treatment with oxamniquine (400 mg/kg), 24 hours after infection. The recovery of schistosomules, at 4, 24, 48 and 72 hours and 35 days after treatment, showed the activity of the drug on the parasites, thus practically preventing their migration from the skin to the lungs. Worm recovery performed in the lungs (96 hours after treatment) showed recovery means of 0.6 worms/mouse in the treated group and 53.8 in the control group (untreated). The perfusion of the portal system carried out at 35 days after treatment clearly showed the elimination of all the parasites in the treated group, whereas a recovery mean of 144.7 worms/mouse was detected in the control group (untreated). These findings confirm the efficacy of oxamniquine at the skin phase of infection, and also show similarity with the immunization method that uses irradiated cercariae. The practical application of these findings in the medical clinic is discussed too Camundongos infectados transcutaneamente com cerca de 400 cercárias foram submetidos a tratamento com oxamniquina (400 mg/kg), 24 horas após a infecção. A recuperação dos esquistossômulos a nível da pele mostrou a atividade da droga nos parasitos e impediu praticamente sua migração para os pulmões. A recuperação a nível pulmonar (96 horas após tratamento) mostrou uma média de 0,6 vermes por camundongo no grupo tratado e 53,8 no grupo controle, não tratado. A perfusão do sistema porta, realizada aos 35 dias após infecção, mostrou claramente a eliminação de todos os parasitos no grupo tratado, enquanto foi recuperada uma média de 144,7 vermes no grupo controle, não tratado. Estes achados vem comprovar a eficácia da oxamniquina na fase cutânea da infecção e mostra analogia com o sistema de imunização que usa cercárias irradiadas. Também se discute a aplicação destes resultados na clínica |
format |
Article in Journal/Newspaper |
author |
Paulo Marcos Zech Coelho Rômulo Teixeira de Mello Silvia Elizabeth Gerken |
author_facet |
Paulo Marcos Zech Coelho Rômulo Teixeira de Mello Silvia Elizabeth Gerken |
author_sort |
Paulo Marcos Zech Coelho |
title |
Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection Schistosoma mansoni: avaliação da atividade da oxamniquina (Mansil*) em esquistossômulos com 24 horas após infecção |
title_short |
Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection Schistosoma mansoni: avaliação da atividade da oxamniquina (Mansil*) em esquistossômulos com 24 horas após infecção |
title_full |
Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection Schistosoma mansoni: avaliação da atividade da oxamniquina (Mansil*) em esquistossômulos com 24 horas após infecção |
title_fullStr |
Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection Schistosoma mansoni: avaliação da atividade da oxamniquina (Mansil*) em esquistossômulos com 24 horas após infecção |
title_full_unstemmed |
Schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection Schistosoma mansoni: avaliação da atividade da oxamniquina (Mansil*) em esquistossômulos com 24 horas após infecção |
title_sort |
schistosoma mansoni: evaluation of the activity of oxamniquine on schistosomules, at 24 hours after infection schistosoma mansoni: avaliação da atividade da oxamniquina (mansil*) em esquistossômulos com 24 horas após infecção |
publisher |
Universidade de São Paulo (USP) |
publishDate |
1993 |
url |
https://doi.org/10.1590/S0036-46651993000600013 https://doaj.org/article/dc10ee885ffb4747aeedc3dc3dfc8bdd |
long_lat |
ENVELOPE(6.521,6.521,62.644,62.644) ENVELOPE(159.167,159.167,-78.100,-78.100) |
geographic |
Arctic Droga The Portal |
geographic_facet |
Arctic Droga The Portal |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 35, Iss 6, Pp 557-561 (1993) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46651993000600013 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46651993000600013 0036-4665 1678-9946 https://doaj.org/article/dc10ee885ffb4747aeedc3dc3dfc8bdd |
op_doi |
https://doi.org/10.1590/S0036-46651993000600013 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
35 |
container_issue |
6 |
container_start_page |
557 |
op_container_end_page |
561 |
_version_ |
1809897648494215168 |