Mosquito metallomics reveal copper and iron as critical factors for Plasmodium infection.

• Published in: PLOS Neglected Tropical Diseases
• Main Authors: Krystal Maya-Maldonado, Victor Cardoso-Jaime, Gabriela González-Olvera, Beatriz Osorio, Benito Recio-Tótoro, Pablo Manrique-Saide, Iram Pablo Rodríguez-Sánchez, Humberto Lanz-Mendoza, Fanis Missirlis, Fidel de la Cruz Hernández-Hernández
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2021
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Stripe
• Online Access: https://doi.org/10.1371/journal.pntd.0009509; https://doaj.org/article/dbe9eeb4d81b4a2ca57b85a7c8d2251b

Iron and copper chelation restricts Plasmodium growth in vitro and in mammalian hosts. The parasite alters metal homeostasis in red blood cells to its favor, for example metabolizing hemoglobin to hemozoin. Metal interactions with the mosquito have not, however, been studied. Here, we describe the m...