Red propolis reduces inflammation in cyclophosphamide-induced hemorrhagic cystitis in rats
Introduction. Cyclophosphamide (CP) is used to treat malignant neoplasias and control autoimmune diseases. Still, one of its metabolites, acrolein, is toxic to the urothelium and can lead to hemorrhagic cystitis and severe discomfort. Objective. To evaluate the ability of red propolis to prevent and...
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Instituto Nacional de Salud
2022
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ftdoajarticles:oai:doaj.org/article:dbc9c5e3fca646d8bb005821c26b1235 2023-05-15T15:10:40+02:00 Red propolis reduces inflammation in cyclophosphamide-induced hemorrhagic cystitis in rats Nayanna de Oliveira Ramos Melo Hélio De Sousa Peres Júnior Clara Araujo Diniz Matheus De Sousa Silva Telma Leda Gomes de Lemos Francisco Vagnaldo Fechine Jamacaru Conceição Aparecida Dornelas 2022-06-01T00:00:00Z https://doi.org/10.7705/biomedica.6087 https://doaj.org/article/dbc9c5e3fca646d8bb005821c26b1235 EN ES eng spa Instituto Nacional de Salud https://revistabiomedica.org/index.php/biomedica/article/view/6087 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.6087 https://doaj.org/article/dbc9c5e3fca646d8bb005821c26b1235 Biomédica: revista del Instituto Nacional de Salud, Vol 42, Iss 2, Pp 253-263 (2022) cystitis cyclophosphamide propolis models animal Medicine R Arctic medicine. Tropical medicine RC955-962 article 2022 ftdoajarticles https://doi.org/10.7705/biomedica.6087 2022-12-30T23:18:49Z Introduction. Cyclophosphamide (CP) is used to treat malignant neoplasias and control autoimmune diseases. Still, one of its metabolites, acrolein, is toxic to the urothelium and can lead to hemorrhagic cystitis and severe discomfort. Objective. To evaluate the ability of red propolis to prevent and treat CP-induced hemorrhagic cystitis in rats. Materials and methods. Red propolis was extracted in 1% gum arabic and administered subcutaneously (sc). In the first experiment, groups IA, IIA, and IIIA and groups IB, IIB, and IIIB received water, gum arabic (GA), or propolis, respectively, for 30 days. Then water (controls) or CP (treatment) was administered i.p. In the second experiment, groups IVA, VA, and VIA received water i.p. while groups IVB, VB, and VIB received CP i.p. This was followed by 5 injections at 2-hour intervals with either water, GA, or propolis. Bladder tissue was examined according to Gray’s criteria. Results. The total inflammatory histology score was significantly smaller in group VIB (11.33 ± 2.07). Mild inflammation predominated in group VIB while most of the animals in group IVB had severe inflammation (p=0.0375). Ulcers were predominantly multiple in Groups IVA and VB but rare or absent in Group VIB (p=0.0118). Urothelial cells were mostly absent in groups IVB and VB and present/normal in group VIB (p=0.0052). Fibrin was abundant in groups IVB and VA but mostly absent in group VIB (p=0.0273). Conclusions. Red propolis can reduce inflammation in CP-induced hemorrhagic cystitis in rats. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 42 2 253 263 |
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English Spanish |
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cystitis cyclophosphamide propolis models animal Medicine R Arctic medicine. Tropical medicine RC955-962 |
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cystitis cyclophosphamide propolis models animal Medicine R Arctic medicine. Tropical medicine RC955-962 Nayanna de Oliveira Ramos Melo Hélio De Sousa Peres Júnior Clara Araujo Diniz Matheus De Sousa Silva Telma Leda Gomes de Lemos Francisco Vagnaldo Fechine Jamacaru Conceição Aparecida Dornelas Red propolis reduces inflammation in cyclophosphamide-induced hemorrhagic cystitis in rats |
topic_facet |
cystitis cyclophosphamide propolis models animal Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction. Cyclophosphamide (CP) is used to treat malignant neoplasias and control autoimmune diseases. Still, one of its metabolites, acrolein, is toxic to the urothelium and can lead to hemorrhagic cystitis and severe discomfort. Objective. To evaluate the ability of red propolis to prevent and treat CP-induced hemorrhagic cystitis in rats. Materials and methods. Red propolis was extracted in 1% gum arabic and administered subcutaneously (sc). In the first experiment, groups IA, IIA, and IIIA and groups IB, IIB, and IIIB received water, gum arabic (GA), or propolis, respectively, for 30 days. Then water (controls) or CP (treatment) was administered i.p. In the second experiment, groups IVA, VA, and VIA received water i.p. while groups IVB, VB, and VIB received CP i.p. This was followed by 5 injections at 2-hour intervals with either water, GA, or propolis. Bladder tissue was examined according to Gray’s criteria. Results. The total inflammatory histology score was significantly smaller in group VIB (11.33 ± 2.07). Mild inflammation predominated in group VIB while most of the animals in group IVB had severe inflammation (p=0.0375). Ulcers were predominantly multiple in Groups IVA and VB but rare or absent in Group VIB (p=0.0118). Urothelial cells were mostly absent in groups IVB and VB and present/normal in group VIB (p=0.0052). Fibrin was abundant in groups IVB and VA but mostly absent in group VIB (p=0.0273). Conclusions. Red propolis can reduce inflammation in CP-induced hemorrhagic cystitis in rats. |
format |
Article in Journal/Newspaper |
author |
Nayanna de Oliveira Ramos Melo Hélio De Sousa Peres Júnior Clara Araujo Diniz Matheus De Sousa Silva Telma Leda Gomes de Lemos Francisco Vagnaldo Fechine Jamacaru Conceição Aparecida Dornelas |
author_facet |
Nayanna de Oliveira Ramos Melo Hélio De Sousa Peres Júnior Clara Araujo Diniz Matheus De Sousa Silva Telma Leda Gomes de Lemos Francisco Vagnaldo Fechine Jamacaru Conceição Aparecida Dornelas |
author_sort |
Nayanna de Oliveira Ramos Melo |
title |
Red propolis reduces inflammation in cyclophosphamide-induced hemorrhagic cystitis in rats |
title_short |
Red propolis reduces inflammation in cyclophosphamide-induced hemorrhagic cystitis in rats |
title_full |
Red propolis reduces inflammation in cyclophosphamide-induced hemorrhagic cystitis in rats |
title_fullStr |
Red propolis reduces inflammation in cyclophosphamide-induced hemorrhagic cystitis in rats |
title_full_unstemmed |
Red propolis reduces inflammation in cyclophosphamide-induced hemorrhagic cystitis in rats |
title_sort |
red propolis reduces inflammation in cyclophosphamide-induced hemorrhagic cystitis in rats |
publisher |
Instituto Nacional de Salud |
publishDate |
2022 |
url |
https://doi.org/10.7705/biomedica.6087 https://doaj.org/article/dbc9c5e3fca646d8bb005821c26b1235 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 42, Iss 2, Pp 253-263 (2022) |
op_relation |
https://revistabiomedica.org/index.php/biomedica/article/view/6087 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.6087 https://doaj.org/article/dbc9c5e3fca646d8bb005821c26b1235 |
op_doi |
https://doi.org/10.7705/biomedica.6087 |
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Biomédica |
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42 |
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2 |
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253 |
op_container_end_page |
263 |
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1766341653428174848 |