Integrins, cancer and snake toxins (mini-review)
Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM). Integrins work as bi-directional mechanotransducers, conveying mechanical signal from outside to inside the cell through a cascade of ph...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:db9f93f43503414bbe3dbbd7ee467d25 2023-05-15T15:05:33+02:00 Integrins, cancer and snake toxins (mini-review) G. Rádis-Baptista 2005-09-01T00:00:00Z https://doi.org/10.1590/S1678-91992005000300002 https://doaj.org/article/db9f93f43503414bbe3dbbd7ee467d25 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000300002 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992005000300002 1678-9199 https://doaj.org/article/db9f93f43503414bbe3dbbd7ee467d25 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 11, Iss 3, Pp 217-241 (2005) integrin angiogenesis cancer apoptosis snake toxin snake venom C-type lectin metalloprotease disintegrin Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2005 ftdoajarticles https://doi.org/10.1590/S1678-91992005000300002 2022-12-31T01:09:40Z Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM). Integrins work as bi-directional mechanotransducers, conveying mechanical signal from outside to inside the cell through a cascade of phosphorylation signals. On the other hand, the signal from inside to outside controls the strength and affinity of integrin adhesion. As proteins of focal contact, integrins are involved in diverse cell functions, such as cell activation, migration, growth, and survival. In the development of neoplastic disease and metastatic tumor, integrins can influence cancer invasiveness and progression, as well as mediate the formation of new blood vessels (angiogenesis). Diverse snake venom toxins have the ability to interact with multiple integrins, what results in inhibition of cell attachment, inhibition of angiogenesis, and induction of apoptotic death of tumor and vascular endothelial cells. The aim of this review is to present data about snake venom toxins that bind to integrins and evoke antiangiogenesis and antitumoral effects. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 11 3 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
integrin angiogenesis cancer apoptosis snake toxin snake venom C-type lectin metalloprotease disintegrin Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
integrin angiogenesis cancer apoptosis snake toxin snake venom C-type lectin metalloprotease disintegrin Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 G. Rádis-Baptista Integrins, cancer and snake toxins (mini-review) |
topic_facet |
integrin angiogenesis cancer apoptosis snake toxin snake venom C-type lectin metalloprotease disintegrin Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Integrins encompass a family of transmembrane heterodimeric proteins of adhesion that maintain cells attached to other cells and to the extracellular matrix (ECM). Integrins work as bi-directional mechanotransducers, conveying mechanical signal from outside to inside the cell through a cascade of phosphorylation signals. On the other hand, the signal from inside to outside controls the strength and affinity of integrin adhesion. As proteins of focal contact, integrins are involved in diverse cell functions, such as cell activation, migration, growth, and survival. In the development of neoplastic disease and metastatic tumor, integrins can influence cancer invasiveness and progression, as well as mediate the formation of new blood vessels (angiogenesis). Diverse snake venom toxins have the ability to interact with multiple integrins, what results in inhibition of cell attachment, inhibition of angiogenesis, and induction of apoptotic death of tumor and vascular endothelial cells. The aim of this review is to present data about snake venom toxins that bind to integrins and evoke antiangiogenesis and antitumoral effects. |
format |
Article in Journal/Newspaper |
author |
G. Rádis-Baptista |
author_facet |
G. Rádis-Baptista |
author_sort |
G. Rádis-Baptista |
title |
Integrins, cancer and snake toxins (mini-review) |
title_short |
Integrins, cancer and snake toxins (mini-review) |
title_full |
Integrins, cancer and snake toxins (mini-review) |
title_fullStr |
Integrins, cancer and snake toxins (mini-review) |
title_full_unstemmed |
Integrins, cancer and snake toxins (mini-review) |
title_sort |
integrins, cancer and snake toxins (mini-review) |
publisher |
SciELO |
publishDate |
2005 |
url |
https://doi.org/10.1590/S1678-91992005000300002 https://doaj.org/article/db9f93f43503414bbe3dbbd7ee467d25 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 11, Iss 3, Pp 217-241 (2005) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992005000300002 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992005000300002 1678-9199 https://doaj.org/article/db9f93f43503414bbe3dbbd7ee467d25 |
op_doi |
https://doi.org/10.1590/S1678-91992005000300002 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
11 |
container_issue |
3 |
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1766337235355959296 |