Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsiveness.
The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a devastating neurodegenerative disease with no effective treatment, which affects an increasing number of people in Brazil. Immune cells from the adaptive compartment are involved in disease m...
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ftdoajarticles:oai:doaj.org/article:db81415417f94efdb20bd8811409b193 2023-05-15T15:06:55+02:00 Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsiveness. Brenda Rocamonde Nicolas Futsch Noemia Orii Omran Allatif Augusto Cesar Penalva de Oliveira Renaud Mahieux Jorge Casseb Hélène Dutartre 2021-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009940 https://doaj.org/article/db81415417f94efdb20bd8811409b193 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009940 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009940 https://doaj.org/article/db81415417f94efdb20bd8811409b193 PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009940 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009940 2022-12-30T20:37:23Z The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a devastating neurodegenerative disease with no effective treatment, which affects an increasing number of people in Brazil. Immune cells from the adaptive compartment are involved in disease manifestation but whether innate cell functions participate in disease occurrence has not been evaluated. In this study, we analyzed innate cell responses at steady state and after blood cell stimulation using an agonist of the toll-like receptor (TLR)7/8-signaling pathway in blood samples from HTLV-1-infected volunteers, including asymptomatic carriers and HAM/TSP patients. We observed a lower response of IFNα+ DCs and monocytes in HAM/TSP compared to asymptomatic carriers, as a potential consequence of corticosteroid treatments. In contrast, a higher frequency of monocytes producing MIP-1α and pDC producing IL-12 was detected in HAM/TSP blood samples, together with higher IFNγ responsiveness of NK cells, suggesting an increased sensitivity to inflammatory response in HAM/TSP patients compared to asymptomatic carriers. This sustained inflammatory responsiveness could be linked or be at the origin of the neuroinflammatory status in HAM/TSP patients. Therefore, the mechanism underlying this dysregulations could shed light onto the origins of HAM/TSP disease. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 11 e0009940 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Brenda Rocamonde Nicolas Futsch Noemia Orii Omran Allatif Augusto Cesar Penalva de Oliveira Renaud Mahieux Jorge Casseb Hélène Dutartre Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsiveness. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The Human T-cell Leukemia Virus-1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) is a devastating neurodegenerative disease with no effective treatment, which affects an increasing number of people in Brazil. Immune cells from the adaptive compartment are involved in disease manifestation but whether innate cell functions participate in disease occurrence has not been evaluated. In this study, we analyzed innate cell responses at steady state and after blood cell stimulation using an agonist of the toll-like receptor (TLR)7/8-signaling pathway in blood samples from HTLV-1-infected volunteers, including asymptomatic carriers and HAM/TSP patients. We observed a lower response of IFNα+ DCs and monocytes in HAM/TSP compared to asymptomatic carriers, as a potential consequence of corticosteroid treatments. In contrast, a higher frequency of monocytes producing MIP-1α and pDC producing IL-12 was detected in HAM/TSP blood samples, together with higher IFNγ responsiveness of NK cells, suggesting an increased sensitivity to inflammatory response in HAM/TSP patients compared to asymptomatic carriers. This sustained inflammatory responsiveness could be linked or be at the origin of the neuroinflammatory status in HAM/TSP patients. Therefore, the mechanism underlying this dysregulations could shed light onto the origins of HAM/TSP disease. |
format |
Article in Journal/Newspaper |
author |
Brenda Rocamonde Nicolas Futsch Noemia Orii Omran Allatif Augusto Cesar Penalva de Oliveira Renaud Mahieux Jorge Casseb Hélène Dutartre |
author_facet |
Brenda Rocamonde Nicolas Futsch Noemia Orii Omran Allatif Augusto Cesar Penalva de Oliveira Renaud Mahieux Jorge Casseb Hélène Dutartre |
author_sort |
Brenda Rocamonde |
title |
Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsiveness. |
title_short |
Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsiveness. |
title_full |
Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsiveness. |
title_fullStr |
Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsiveness. |
title_full_unstemmed |
Immunoprofiling of fresh HAM/TSP blood samples shows altered innate cell responsiveness. |
title_sort |
immunoprofiling of fresh ham/tsp blood samples shows altered innate cell responsiveness. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009940 https://doaj.org/article/db81415417f94efdb20bd8811409b193 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009940 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009940 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009940 https://doaj.org/article/db81415417f94efdb20bd8811409b193 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009940 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
11 |
container_start_page |
e0009940 |
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