Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia
Abstract Background Plasmodium vivax accounts for about 40% of all malaria infection in Ethiopia. Chloroquine (CQ) is the first line treatment for confirmed P. vivax malaria in the country. The first report of CQ treatment failure in P. vivax was from Debre Zeit, which suggested the presence of chlo...
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ftdoajarticles:oai:doaj.org/article:db6019f1c6af4e819e733ae392f6bffd 2023-05-15T15:11:48+02:00 Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia Muchohi Simon Elhassan Ibrahim Tesfaye Gezahegn Yamuah Lawrence Petros Beyene Teka Hiwot Kokwaro Gilbert Aseffa Abraham Engers Howard 2008-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-220 https://doaj.org/article/db6019f1c6af4e819e733ae392f6bffd EN eng BMC http://www.malariajournal.com/content/7/1/220 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-220 1475-2875 https://doaj.org/article/db6019f1c6af4e819e733ae392f6bffd Malaria Journal, Vol 7, Iss 1, p 220 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-220 2022-12-31T04:20:53Z Abstract Background Plasmodium vivax accounts for about 40% of all malaria infection in Ethiopia. Chloroquine (CQ) is the first line treatment for confirmed P. vivax malaria in the country. The first report of CQ treatment failure in P. vivax was from Debre Zeit, which suggested the presence of chloroquine resistance. Methods An in vivo drug efficacy study was conducted in Debre Zeit from June to August 2006. Eighty-seven patients with microscopically confirmed P. vivax malaria, aged between 8 months and 52 years, were recruited and treated under supervision with CQ (25 mg/kg over three days). Clinical and parasitological parameters were assessed during the 28 day follow-up period. CQ and desethylchloroquine (DCQ) blood and serum concentrations were determined with high performance liquid chromatography (HPLC) in patients who showed recurrent parasitaemia. Results Of the 87 patients recruited in the study, one was lost to follow-up and three were excluded due to P. falciparum infection during follow-up. A total of 83 (95%) of the study participants completed the follow-up. On enrolment, 39.8% had documented fever and 60.2% had a history of fever. The geometric mean parasite density of the patients was 7045 parasites/μl. Among these, four patients had recurrent parasitaemia on Day 28. The blood CQ plus DCQ concentrations of these four patients were all above the minimal effective concentration (> 100 ng/ml). Conclusion Chloroquine-resistant P. vivax parasites are emerging in Debre Zeit, Ethiopia. A multi-centre national survey is needed to better understand the extent of P. vivax resistance to CQ in Ethiopia. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Muchohi Simon Elhassan Ibrahim Tesfaye Gezahegn Yamuah Lawrence Petros Beyene Teka Hiwot Kokwaro Gilbert Aseffa Abraham Engers Howard Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Plasmodium vivax accounts for about 40% of all malaria infection in Ethiopia. Chloroquine (CQ) is the first line treatment for confirmed P. vivax malaria in the country. The first report of CQ treatment failure in P. vivax was from Debre Zeit, which suggested the presence of chloroquine resistance. Methods An in vivo drug efficacy study was conducted in Debre Zeit from June to August 2006. Eighty-seven patients with microscopically confirmed P. vivax malaria, aged between 8 months and 52 years, were recruited and treated under supervision with CQ (25 mg/kg over three days). Clinical and parasitological parameters were assessed during the 28 day follow-up period. CQ and desethylchloroquine (DCQ) blood and serum concentrations were determined with high performance liquid chromatography (HPLC) in patients who showed recurrent parasitaemia. Results Of the 87 patients recruited in the study, one was lost to follow-up and three were excluded due to P. falciparum infection during follow-up. A total of 83 (95%) of the study participants completed the follow-up. On enrolment, 39.8% had documented fever and 60.2% had a history of fever. The geometric mean parasite density of the patients was 7045 parasites/μl. Among these, four patients had recurrent parasitaemia on Day 28. The blood CQ plus DCQ concentrations of these four patients were all above the minimal effective concentration (> 100 ng/ml). Conclusion Chloroquine-resistant P. vivax parasites are emerging in Debre Zeit, Ethiopia. A multi-centre national survey is needed to better understand the extent of P. vivax resistance to CQ in Ethiopia. |
format |
Article in Journal/Newspaper |
author |
Muchohi Simon Elhassan Ibrahim Tesfaye Gezahegn Yamuah Lawrence Petros Beyene Teka Hiwot Kokwaro Gilbert Aseffa Abraham Engers Howard |
author_facet |
Muchohi Simon Elhassan Ibrahim Tesfaye Gezahegn Yamuah Lawrence Petros Beyene Teka Hiwot Kokwaro Gilbert Aseffa Abraham Engers Howard |
author_sort |
Muchohi Simon |
title |
Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia |
title_short |
Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia |
title_full |
Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia |
title_fullStr |
Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia |
title_full_unstemmed |
Chloroquine-resistant Plasmodium vivax malaria in Debre Zeit, Ethiopia |
title_sort |
chloroquine-resistant plasmodium vivax malaria in debre zeit, ethiopia |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-220 https://doaj.org/article/db6019f1c6af4e819e733ae392f6bffd |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 220 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/220 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-220 1475-2875 https://doaj.org/article/db6019f1c6af4e819e733ae392f6bffd |
op_doi |
https://doi.org/10.1186/1475-2875-7-220 |
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Malaria Journal |
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7 |
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1 |
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1766342592161644544 |