Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources?
Abstract Background Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources and this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs in human sera, allowing better profiling of PFAS e...
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ftdoajarticles:oai:doaj.org/article:db4d6633453449d09ddb4e58d2aea622 2023-05-15T16:11:02+02:00 Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources? Xindi C. Hu Clifton Dassuncao Xianming Zhang Philippe Grandjean Pál Weihe Glenys M. Webster Flemming Nielsen Elsie M. Sunderland 2018-02-01T00:00:00Z https://doi.org/10.1186/s12940-018-0355-4 https://doaj.org/article/db4d6633453449d09ddb4e58d2aea622 EN eng BMC http://link.springer.com/article/10.1186/s12940-018-0355-4 https://doaj.org/toc/1476-069X doi:10.1186/s12940-018-0355-4 1476-069X https://doaj.org/article/db4d6633453449d09ddb4e58d2aea622 Environmental Health, Vol 17, Iss 1, Pp 1-15 (2018) Serum Fish and shellfish Consumer products Source attribution Homologues Perfluoroalkyl carboxylates (PFCAs) Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1186/s12940-018-0355-4 2022-12-31T12:21:03Z Abstract Background Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources and this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs in human sera, allowing better profiling of PFAS exposures. The composition of PFASs in human sera reflects the complexity of exposure sources but source identification can be confounded by differences in toxicokinetics affecting uptake, distribution, and elimination. Common PFASs, such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS) and their precursors are ubiquitous in multiple exposure sources. However, their composition varies among sources, which may impact associated adverse health effects. Methods We use available PFAS concentrations from several demographic groups in a North Atlantic seafood consuming population (Faroe Islands) to explore whether chemical fingerprints in human sera provide insights into predominant exposure sources. We compare serum PFAS profiles from Faroese individuals to other North American populations to investigate commonalities in potential exposure sources. We compare individuals with similar demographic and physiological characteristics and samples from the same years to reduce confounding by toxicokinetic differences and changing environmental releases. Results Using principal components analysis (PCA) confirmed by hierarchical clustering, we assess variability in serum PFAS concentrations across three Faroese groups. The first principal component (PC)/cluster consists of C9-C12 perfluoroalkyl carboxylates (PFCAs) and is consistent with measured PFAS profiles in consumed seafood. The second PC/cluster includes perfluorohexanesulfonic acid (PFHxS) and the PFOS precursor N-ethyl perfluorooctane sulfonamidoacetate (N-EtFOSAA), which are directly used or metabolized from fluorochemicals in consumer products such as carpet and food packaging. We find that the same compounds are associated with the same exposure ... Article in Journal/Newspaper Faroe Islands North Atlantic Directory of Open Access Journals: DOAJ Articles Faroe Islands Environmental Health 17 1 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Serum Fish and shellfish Consumer products Source attribution Homologues Perfluoroalkyl carboxylates (PFCAs) Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270 |
spellingShingle |
Serum Fish and shellfish Consumer products Source attribution Homologues Perfluoroalkyl carboxylates (PFCAs) Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270 Xindi C. Hu Clifton Dassuncao Xianming Zhang Philippe Grandjean Pál Weihe Glenys M. Webster Flemming Nielsen Elsie M. Sunderland Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources? |
topic_facet |
Serum Fish and shellfish Consumer products Source attribution Homologues Perfluoroalkyl carboxylates (PFCAs) Industrial medicine. Industrial hygiene RC963-969 Public aspects of medicine RA1-1270 |
description |
Abstract Background Humans are exposed to poly- and perfluoroalkyl substances (PFASs) from diverse sources and this has been associated with negative health impacts. Advances in analytical methods have enabled routine detection of more than 15 PFASs in human sera, allowing better profiling of PFAS exposures. The composition of PFASs in human sera reflects the complexity of exposure sources but source identification can be confounded by differences in toxicokinetics affecting uptake, distribution, and elimination. Common PFASs, such as perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS) and their precursors are ubiquitous in multiple exposure sources. However, their composition varies among sources, which may impact associated adverse health effects. Methods We use available PFAS concentrations from several demographic groups in a North Atlantic seafood consuming population (Faroe Islands) to explore whether chemical fingerprints in human sera provide insights into predominant exposure sources. We compare serum PFAS profiles from Faroese individuals to other North American populations to investigate commonalities in potential exposure sources. We compare individuals with similar demographic and physiological characteristics and samples from the same years to reduce confounding by toxicokinetic differences and changing environmental releases. Results Using principal components analysis (PCA) confirmed by hierarchical clustering, we assess variability in serum PFAS concentrations across three Faroese groups. The first principal component (PC)/cluster consists of C9-C12 perfluoroalkyl carboxylates (PFCAs) and is consistent with measured PFAS profiles in consumed seafood. The second PC/cluster includes perfluorohexanesulfonic acid (PFHxS) and the PFOS precursor N-ethyl perfluorooctane sulfonamidoacetate (N-EtFOSAA), which are directly used or metabolized from fluorochemicals in consumer products such as carpet and food packaging. We find that the same compounds are associated with the same exposure ... |
format |
Article in Journal/Newspaper |
author |
Xindi C. Hu Clifton Dassuncao Xianming Zhang Philippe Grandjean Pál Weihe Glenys M. Webster Flemming Nielsen Elsie M. Sunderland |
author_facet |
Xindi C. Hu Clifton Dassuncao Xianming Zhang Philippe Grandjean Pál Weihe Glenys M. Webster Flemming Nielsen Elsie M. Sunderland |
author_sort |
Xindi C. Hu |
title |
Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources? |
title_short |
Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources? |
title_full |
Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources? |
title_fullStr |
Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources? |
title_full_unstemmed |
Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources? |
title_sort |
can profiles of poly- and perfluoroalkyl substances (pfass) in human serum provide information on major exposure sources? |
publisher |
BMC |
publishDate |
2018 |
url |
https://doi.org/10.1186/s12940-018-0355-4 https://doaj.org/article/db4d6633453449d09ddb4e58d2aea622 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands North Atlantic |
genre_facet |
Faroe Islands North Atlantic |
op_source |
Environmental Health, Vol 17, Iss 1, Pp 1-15 (2018) |
op_relation |
http://link.springer.com/article/10.1186/s12940-018-0355-4 https://doaj.org/toc/1476-069X doi:10.1186/s12940-018-0355-4 1476-069X https://doaj.org/article/db4d6633453449d09ddb4e58d2aea622 |
op_doi |
https://doi.org/10.1186/s12940-018-0355-4 |
container_title |
Environmental Health |
container_volume |
17 |
container_issue |
1 |
_version_ |
1765996161206845440 |