Neuritogenic effect of sea cucumber glucocerebrosides on NGF-induced PC12 cells via activation of the TrkA/CREB/BDNF signalling pathway

• Published in: Journal of Functional Foods
• Main Authors: Xiaoxu Wang, Peixu Cong, Yanjun Liu, Suyuan Tao, Qinsheng Chen, Jingfeng Wang, Jie Xu, Changhu Xue
• Format: Article in Journal/Newspaper
• Language: English
• Published: Elsevier 2018
• Subjects: PC12 cells; Sea cucumber cerebrosides; Neuritogenic effect; TrkA; CREB; BDNF; Nutrition. Foods and food supply; TX341-641; Mek; Cucumaria frondosa
• Online Access: https://doi.org/10.1016/j.jff.2018.04.035; https://doaj.org/article/db314bde19e4483eb402f9668d7965cb

Sea cucumber glucocerebrosides (SCGs), an important sphingolipid, have extensive functions in inhibiting the growth of cancer cells, but their potential to promote neuronal outgrowth hasn’t been well studied. Herein, we evaluated the neuritogenic effects of three Cucumaria frondosa SCGs series (SCG-...