Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach
Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-gu...
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ftdoajarticles:oai:doaj.org/article:db0d181c607341afa263f0c304a84db8 2024-09-09T19:26:02+00:00 Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach Siti Junaidah Ahmad Mohd Badrin Hanizam Abdul Rahim Syarul Nataqain Baharum Mohd Shukri Baba Noraziah Mohamad Zin 2017-01-01T00:00:00Z https://doi.org/10.1155/2017/2189814 https://doaj.org/article/db0d181c607341afa263f0c304a84db8 EN eng Wiley http://dx.doi.org/10.1155/2017/2189814 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2017/2189814 https://doaj.org/article/db0d181c607341afa263f0c304a84db8 Journal of Tropical Medicine, Vol 2017 (2017) Arctic medicine. Tropical medicine RC955-962 article 2017 ftdoajarticles https://doi.org/10.1155/2017/2189814 2024-08-05T17:48:38Z Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process. Metabolomics is an emerging “omics” technology in systems biology study which integrated in process of discovering drug from natural products. Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process. The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (1H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds. The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products. Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2017 1 7 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Siti Junaidah Ahmad Mohd Badrin Hanizam Abdul Rahim Syarul Nataqain Baharum Mohd Shukri Baba Noraziah Mohamad Zin Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Natural products continue to play an important role as a source of biologically active substances for the development of new drug. Streptomyces, Gram-positive bacteria which are widely distributed in nature, are one of the most popular sources of natural antibiotics. Recently, by using a bioassay-guided fractionation, an antimalarial compound, Gancidin-W, has been discovered from these bacteria. However, this classical method in identifying potentially novel bioactive compounds from the natural products requires considerable effort and is a time-consuming process. Metabolomics is an emerging “omics” technology in systems biology study which integrated in process of discovering drug from natural products. Metabolomics approach in finding novel therapeutics agent for malaria offers dereplication step in screening phase to shorten the process. The highly sensitive instruments, such as Liquid Chromatography-Mass Spectrophotometry (LC-MS), Gas Chromatography-Mass Spectrophotometry (GC-MS), and Nuclear Magnetic Resonance (1H-NMR) spectroscopy, provide a wide range of information in the identification of potentially bioactive compounds. The current paper reviews concepts of metabolomics and its application in drug discovery of malaria treatment as well as assessing the antimalarial activity from natural products. Metabolomics approach in malaria drug discovery is still new and needs to be initiated, especially for drug research in Malaysia. |
format |
Article in Journal/Newspaper |
author |
Siti Junaidah Ahmad Mohd Badrin Hanizam Abdul Rahim Syarul Nataqain Baharum Mohd Shukri Baba Noraziah Mohamad Zin |
author_facet |
Siti Junaidah Ahmad Mohd Badrin Hanizam Abdul Rahim Syarul Nataqain Baharum Mohd Shukri Baba Noraziah Mohamad Zin |
author_sort |
Siti Junaidah Ahmad |
title |
Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach |
title_short |
Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach |
title_full |
Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach |
title_fullStr |
Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach |
title_full_unstemmed |
Discovery of Antimalarial Drugs from Streptomycetes Metabolites Using a Metabolomic Approach |
title_sort |
discovery of antimalarial drugs from streptomycetes metabolites using a metabolomic approach |
publisher |
Wiley |
publishDate |
2017 |
url |
https://doi.org/10.1155/2017/2189814 https://doaj.org/article/db0d181c607341afa263f0c304a84db8 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2017 (2017) |
op_relation |
http://dx.doi.org/10.1155/2017/2189814 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2017/2189814 https://doaj.org/article/db0d181c607341afa263f0c304a84db8 |
op_doi |
https://doi.org/10.1155/2017/2189814 |
container_title |
Journal of Tropical Medicine |
container_volume |
2017 |
container_start_page |
1 |
op_container_end_page |
7 |
_version_ |
1809895742144249856 |