Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach.
Leishmania (Leishmania) infantum is the zoonotic agent of visceral leishmaniasis (VL), a disease with a global distribution. The transmission scenario of VL has been undergoing changes worldwide, with the biologic cycle invading urbanized areas and dispersing the parasites into other previously free...
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ftdoajarticles:oai:doaj.org/article:dab4d91da28d4f9ab2139a8d5fe81481 2023-05-15T15:10:02+02:00 Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach. Aline Kuhn Sbruzzi Pasquali Rafael Antunes Baggio Walter Antonio Boeger Nilsa González-Britez Deborah Carbonera Guedes Enmanuel Céspedes Chaves Vanete Thomaz-Soccol 2019-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007639 https://doaj.org/article/dab4d91da28d4f9ab2139a8d5fe81481 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007639 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007639 https://doaj.org/article/dab4d91da28d4f9ab2139a8d5fe81481 PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007639 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007639 2022-12-31T07:17:08Z Leishmania (Leishmania) infantum is the zoonotic agent of visceral leishmaniasis (VL), a disease with a global distribution. The transmission scenario of VL has been undergoing changes worldwide, with the biologic cycle invading urbanized areas and dispersing the parasites into other previously free areas. The epidemiological cycle in Brazil has dispersed from the Northeast to other regions of the country. In this study, an integrative approach, including genotyping Brazilian strains of L. (L.) infantum for 14 microsatellite markers and reviewing historical records of the disease, was used to assess dispersion routes throughout central-southern Brazil. Our results support three L. (L.) infantum dispersion routes: A) dispersion from Bolivia to the states of Mato Grosso, Mato Grosso do Sul and São Paulo via the Bolivia-Brazil gas pipeline from 1998 to 2005; B) VL dispersion from Paraguay to the Brazilian side of the triple border (Foz do Iguaçu and Santa Terezinha de Itaipu) during after 2012; and C) emergence of a new L. (L.) infantum cluster in western Santa Catarina State and its dispersion to southern Paraná State (municipality of Pato Branco), after 2013. Hypotheses regarding possible entries of Leishmania (L.) infantum into the area of the triple border are presented and discussed. Understanding how VL has dispersed is vital to the development of control measures for this disease and to avoid future dispersion events. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 8 e0007639 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Aline Kuhn Sbruzzi Pasquali Rafael Antunes Baggio Walter Antonio Boeger Nilsa González-Britez Deborah Carbonera Guedes Enmanuel Céspedes Chaves Vanete Thomaz-Soccol Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Leishmania (Leishmania) infantum is the zoonotic agent of visceral leishmaniasis (VL), a disease with a global distribution. The transmission scenario of VL has been undergoing changes worldwide, with the biologic cycle invading urbanized areas and dispersing the parasites into other previously free areas. The epidemiological cycle in Brazil has dispersed from the Northeast to other regions of the country. In this study, an integrative approach, including genotyping Brazilian strains of L. (L.) infantum for 14 microsatellite markers and reviewing historical records of the disease, was used to assess dispersion routes throughout central-southern Brazil. Our results support three L. (L.) infantum dispersion routes: A) dispersion from Bolivia to the states of Mato Grosso, Mato Grosso do Sul and São Paulo via the Bolivia-Brazil gas pipeline from 1998 to 2005; B) VL dispersion from Paraguay to the Brazilian side of the triple border (Foz do Iguaçu and Santa Terezinha de Itaipu) during after 2012; and C) emergence of a new L. (L.) infantum cluster in western Santa Catarina State and its dispersion to southern Paraná State (municipality of Pato Branco), after 2013. Hypotheses regarding possible entries of Leishmania (L.) infantum into the area of the triple border are presented and discussed. Understanding how VL has dispersed is vital to the development of control measures for this disease and to avoid future dispersion events. |
format |
Article in Journal/Newspaper |
author |
Aline Kuhn Sbruzzi Pasquali Rafael Antunes Baggio Walter Antonio Boeger Nilsa González-Britez Deborah Carbonera Guedes Enmanuel Céspedes Chaves Vanete Thomaz-Soccol |
author_facet |
Aline Kuhn Sbruzzi Pasquali Rafael Antunes Baggio Walter Antonio Boeger Nilsa González-Britez Deborah Carbonera Guedes Enmanuel Céspedes Chaves Vanete Thomaz-Soccol |
author_sort |
Aline Kuhn Sbruzzi Pasquali |
title |
Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach. |
title_short |
Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach. |
title_full |
Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach. |
title_fullStr |
Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach. |
title_full_unstemmed |
Dispersion of Leishmania (Leishmania) infantum in central-southern Brazil: Evidence from an integrative approach. |
title_sort |
dispersion of leishmania (leishmania) infantum in central-southern brazil: evidence from an integrative approach. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007639 https://doaj.org/article/dab4d91da28d4f9ab2139a8d5fe81481 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 8, p e0007639 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007639 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007639 https://doaj.org/article/dab4d91da28d4f9ab2139a8d5fe81481 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007639 |
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PLOS Neglected Tropical Diseases |
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13 |
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8 |
container_start_page |
e0007639 |
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