The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus

Abstract Background It is anticipated that malaria elimination efforts in Africa will be hampered by increasing resistance to the limited arsenal of insecticides approved for use in public health. However, insecticide susceptibility status of vector populations evaluated under standard insectary tes...

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Published in:Malaria Journal
Main Authors: Katey D. Glunt, Shüné V. Oliver, Richard H. Hunt, Krijn P. Paaijmans
Format: Article in Journal/Newspaper
Language:English
Published: BMC 2018
Subjects:
Online Access:https://doi.org/10.1186/s12936-018-2250-4
https://doaj.org/article/daa13262d18545ac8c33beb889bf5cf2
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spelling ftdoajarticles:oai:doaj.org/article:daa13262d18545ac8c33beb889bf5cf2 2023-05-15T15:14:23+02:00 The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus Katey D. Glunt Shüné V. Oliver Richard H. Hunt Krijn P. Paaijmans 2018-04-01T00:00:00Z https://doi.org/10.1186/s12936-018-2250-4 https://doaj.org/article/daa13262d18545ac8c33beb889bf5cf2 EN eng BMC http://link.springer.com/article/10.1186/s12936-018-2250-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-018-2250-4 1475-2875 https://doaj.org/article/daa13262d18545ac8c33beb889bf5cf2 Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018) Anopheles funestus Anopheles arabiensis WHO tube bioassays Environmental variation Insecticide resistance Malaria elimination Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1186/s12936-018-2250-4 2022-12-31T00:15:55Z Abstract Background It is anticipated that malaria elimination efforts in Africa will be hampered by increasing resistance to the limited arsenal of insecticides approved for use in public health. However, insecticide susceptibility status of vector populations evaluated under standard insectary test conditions can give a false picture of the threat, as the thermal environment in which the insect and insecticide interact plays a significant role in insecticide toxicity. Methods The effect of temperature on the expression of the standard WHO insecticide resistance phenotype was examined using Anopheles arabiensis and Anopheles funestus strains: a susceptible strain and the derived resistant strain, selected in the laboratory for resistance to DDT or pyrethroids. The susceptibility of mosquitoes to the pyrethroid deltamethrin or the carbamate bendiocarb was assessed at 18, 25 or 30 °C. The ability of the pyrethroid synergist piperonyl-butoxide (PBO) to restore pyrethroid susceptibility was also assessed at these temperatures. Results Temperature impacted the toxicity of deltamethrin and bendiocarb. Although the resistant An. funestus strain was uniformly resistant to deltamethrin across temperatures, increasing temperature increased the resistance of the susceptible An. arabiensis strain. Against susceptible An. funestus and resistant An. arabiensis females, deltamethrin exposure at temperatures both lower and higher than standard insectary conditions increased mortality. PBO exposure completely restored deltamethrin susceptibility at all temperatures. Bendiocarb displayed a consistently positive temperature coefficient against both susceptible and resistant An. funestus strains, with survival increasing as temperature increased. Conclusions Environmental temperature has a marked effect on the efficacy of insecticides used in public health against important African malaria vectors. Caution must be exercised when drawing conclusions about a chemical’s efficacy from laboratory assays performed at only one ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 17 1
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Anopheles funestus
Anopheles arabiensis
WHO tube bioassays
Environmental variation
Insecticide resistance
Malaria elimination
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
spellingShingle Anopheles funestus
Anopheles arabiensis
WHO tube bioassays
Environmental variation
Insecticide resistance
Malaria elimination
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
Katey D. Glunt
Shüné V. Oliver
Richard H. Hunt
Krijn P. Paaijmans
The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus
topic_facet Anopheles funestus
Anopheles arabiensis
WHO tube bioassays
Environmental variation
Insecticide resistance
Malaria elimination
Arctic medicine. Tropical medicine
RC955-962
Infectious and parasitic diseases
RC109-216
description Abstract Background It is anticipated that malaria elimination efforts in Africa will be hampered by increasing resistance to the limited arsenal of insecticides approved for use in public health. However, insecticide susceptibility status of vector populations evaluated under standard insectary test conditions can give a false picture of the threat, as the thermal environment in which the insect and insecticide interact plays a significant role in insecticide toxicity. Methods The effect of temperature on the expression of the standard WHO insecticide resistance phenotype was examined using Anopheles arabiensis and Anopheles funestus strains: a susceptible strain and the derived resistant strain, selected in the laboratory for resistance to DDT or pyrethroids. The susceptibility of mosquitoes to the pyrethroid deltamethrin or the carbamate bendiocarb was assessed at 18, 25 or 30 °C. The ability of the pyrethroid synergist piperonyl-butoxide (PBO) to restore pyrethroid susceptibility was also assessed at these temperatures. Results Temperature impacted the toxicity of deltamethrin and bendiocarb. Although the resistant An. funestus strain was uniformly resistant to deltamethrin across temperatures, increasing temperature increased the resistance of the susceptible An. arabiensis strain. Against susceptible An. funestus and resistant An. arabiensis females, deltamethrin exposure at temperatures both lower and higher than standard insectary conditions increased mortality. PBO exposure completely restored deltamethrin susceptibility at all temperatures. Bendiocarb displayed a consistently positive temperature coefficient against both susceptible and resistant An. funestus strains, with survival increasing as temperature increased. Conclusions Environmental temperature has a marked effect on the efficacy of insecticides used in public health against important African malaria vectors. Caution must be exercised when drawing conclusions about a chemical’s efficacy from laboratory assays performed at only one ...
format Article in Journal/Newspaper
author Katey D. Glunt
Shüné V. Oliver
Richard H. Hunt
Krijn P. Paaijmans
author_facet Katey D. Glunt
Shüné V. Oliver
Richard H. Hunt
Krijn P. Paaijmans
author_sort Katey D. Glunt
title The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus
title_short The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus
title_full The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus
title_fullStr The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus
title_full_unstemmed The impact of temperature on insecticide toxicity against the malaria vectors Anopheles arabiensis and Anopheles funestus
title_sort impact of temperature on insecticide toxicity against the malaria vectors anopheles arabiensis and anopheles funestus
publisher BMC
publishDate 2018
url https://doi.org/10.1186/s12936-018-2250-4
https://doaj.org/article/daa13262d18545ac8c33beb889bf5cf2
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source Malaria Journal, Vol 17, Iss 1, Pp 1-8 (2018)
op_relation http://link.springer.com/article/10.1186/s12936-018-2250-4
https://doaj.org/toc/1475-2875
doi:10.1186/s12936-018-2250-4
1475-2875
https://doaj.org/article/daa13262d18545ac8c33beb889bf5cf2
op_doi https://doi.org/10.1186/s12936-018-2250-4
container_title Malaria Journal
container_volume 17
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