Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study
Abstract Background Vertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk....
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ftdoajarticles:oai:doaj.org/article:da75a6f850704335900a180bff402a54 2023-05-15T18:34:31+02:00 Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study Waterloo Svanhild Nguyen Tuan Ahmed Luai A Center Jacqueline R Morseth Bente Nguyen Nguyen D Eisman John A Søgaard Anne J Emaus Nina 2012-08-01T00:00:00Z https://doi.org/10.1186/1471-2474-13-163 https://doaj.org/article/da75a6f850704335900a180bff402a54 EN eng BMC http://www.biomedcentral.com/1471-2474/13/163 https://doaj.org/toc/1471-2474 doi:10.1186/1471-2474-13-163 1471-2474 https://doaj.org/article/da75a6f850704335900a180bff402a54 BMC Musculoskeletal Disorders, Vol 13, Iss 1, p 163 (2012) Morphometry Vertebral fractures Risk factors Population based study Population attributable risk (par) Diseases of the musculoskeletal system RC925-935 article 2012 ftdoajarticles https://doi.org/10.1186/1471-2474-13-163 2022-12-31T07:26:19Z Abstract Background Vertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk. Methods Vertebral fracture was ascertained by VFA method (DXA, GE Lunar Prodigy) in 2887 men and women, aged between 38 and 87 years, in the population-based Tromsø Study 2007/2008. Bone mineral density (BMD; g/cm 2 ) at the hip was measured by DXA. Lifestyle information was collected by questionnaires. Multivariable logistic regression model, with anthropometric and lifestyle factors included, was used to assess the association between each or combined risk factors and vertebral fracture risk. Population attributable risk was estimated for combined risk factors in the final multivariable model. Results In both sexes, age (odds ratio [OR] per 5 year increase: 1.32; 95% CI 1.19-1.45 in women and 1.21; 95% CI 1.10-1.33 in men) and BMD (OR per SD decrease: 1.60; 95% CI 1.34-1.90 in women and1.40; 95% CI 1.18-1.67 in men) were independent risk factors for vertebral fracture. At BMD levels higher than 0.85 g/cm 2 , men had a greater risk of fracture than women (OR 1.52; 95% CI 1.14-2.04), after adjusting for age. In women and men, respectively, approximately 46% and 33% of vertebral fracture risk was attributable to advancing age (more than 70 years) and low BMD (less than 0.85 g/cm 2 ), with the latter having a greater effect than the former. Conclusions These data confirm that age and BMD are major risk factors for vertebral fracture risk. However, in both sexes the two factors accounted for less than half of fracture risk. The identification of individuals with vertebral fracture is still a challenge. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Tromsø BMC Musculoskeletal Disorders 13 1 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Morphometry Vertebral fractures Risk factors Population based study Population attributable risk (par) Diseases of the musculoskeletal system RC925-935 |
spellingShingle |
Morphometry Vertebral fractures Risk factors Population based study Population attributable risk (par) Diseases of the musculoskeletal system RC925-935 Waterloo Svanhild Nguyen Tuan Ahmed Luai A Center Jacqueline R Morseth Bente Nguyen Nguyen D Eisman John A Søgaard Anne J Emaus Nina Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
topic_facet |
Morphometry Vertebral fractures Risk factors Population based study Population attributable risk (par) Diseases of the musculoskeletal system RC925-935 |
description |
Abstract Background Vertebral fractures, the most common type of osteoporotic fractures, are associated with increased risk of subsequent fracture, morbidity, and mortality. The aim of this study was to examine the contribution of important risk factors to the variability in vertebral fracture risk. Methods Vertebral fracture was ascertained by VFA method (DXA, GE Lunar Prodigy) in 2887 men and women, aged between 38 and 87 years, in the population-based Tromsø Study 2007/2008. Bone mineral density (BMD; g/cm 2 ) at the hip was measured by DXA. Lifestyle information was collected by questionnaires. Multivariable logistic regression model, with anthropometric and lifestyle factors included, was used to assess the association between each or combined risk factors and vertebral fracture risk. Population attributable risk was estimated for combined risk factors in the final multivariable model. Results In both sexes, age (odds ratio [OR] per 5 year increase: 1.32; 95% CI 1.19-1.45 in women and 1.21; 95% CI 1.10-1.33 in men) and BMD (OR per SD decrease: 1.60; 95% CI 1.34-1.90 in women and1.40; 95% CI 1.18-1.67 in men) were independent risk factors for vertebral fracture. At BMD levels higher than 0.85 g/cm 2 , men had a greater risk of fracture than women (OR 1.52; 95% CI 1.14-2.04), after adjusting for age. In women and men, respectively, approximately 46% and 33% of vertebral fracture risk was attributable to advancing age (more than 70 years) and low BMD (less than 0.85 g/cm 2 ), with the latter having a greater effect than the former. Conclusions These data confirm that age and BMD are major risk factors for vertebral fracture risk. However, in both sexes the two factors accounted for less than half of fracture risk. The identification of individuals with vertebral fracture is still a challenge. |
format |
Article in Journal/Newspaper |
author |
Waterloo Svanhild Nguyen Tuan Ahmed Luai A Center Jacqueline R Morseth Bente Nguyen Nguyen D Eisman John A Søgaard Anne J Emaus Nina |
author_facet |
Waterloo Svanhild Nguyen Tuan Ahmed Luai A Center Jacqueline R Morseth Bente Nguyen Nguyen D Eisman John A Søgaard Anne J Emaus Nina |
author_sort |
Waterloo Svanhild |
title |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_short |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_full |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_fullStr |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_full_unstemmed |
Important risk factors and attributable risk of vertebral fractures in the population-based Tromsø study |
title_sort |
important risk factors and attributable risk of vertebral fractures in the population-based tromsø study |
publisher |
BMC |
publishDate |
2012 |
url |
https://doi.org/10.1186/1471-2474-13-163 https://doaj.org/article/da75a6f850704335900a180bff402a54 |
geographic |
Tromsø |
geographic_facet |
Tromsø |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
BMC Musculoskeletal Disorders, Vol 13, Iss 1, p 163 (2012) |
op_relation |
http://www.biomedcentral.com/1471-2474/13/163 https://doaj.org/toc/1471-2474 doi:10.1186/1471-2474-13-163 1471-2474 https://doaj.org/article/da75a6f850704335900a180bff402a54 |
op_doi |
https://doi.org/10.1186/1471-2474-13-163 |
container_title |
BMC Musculoskeletal Disorders |
container_volume |
13 |
container_issue |
1 |
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