INCIDENCE OF DIARRHEA BY Clostridium difficile IN HEMATOLOGIC PATIENTS AND HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: RISK FACTORS FOR SEVERE FORMS AND DEATH
We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors associated with...
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Universidade de São Paulo (USP)
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Online Access: | https://doi.org/10.1590/S0036-46652014000400010 https://doaj.org/article/da533983ab004ce0b7dd9a909eadfda5 |
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ftdoajarticles:oai:doaj.org/article:da533983ab004ce0b7dd9a909eadfda5 2024-09-09T19:26:46+00:00 INCIDENCE OF DIARRHEA BY Clostridium difficile IN HEMATOLOGIC PATIENTS AND HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: RISK FACTORS FOR SEVERE FORMS AND DEATH Fernanda Spadão Juliana Gerhardt Thais Guimarães Frederico Dulley João Nóbrega de Almeida Junior Marjorie Vieira Batista Maria Aparecida Shikanai-Yasuda Anna Sara Levin Silvia Figueiredo Costa 2014-07-01T00:00:00Z https://doi.org/10.1590/S0036-46652014000400010 https://doaj.org/article/da533983ab004ce0b7dd9a909eadfda5 EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652014000400325&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652014000400010 https://doaj.org/article/da533983ab004ce0b7dd9a909eadfda5 Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 4, Pp 325-331 (2014) Hematology Bone marrow transplant C. difficile Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2014 ftdoajarticles https://doi.org/10.1590/S0036-46652014000400010 2024-08-05T17:49:30Z We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors associated with the severe form of the disease and death. The ELISA method (Ridascreen-Biopharm, Germany) for the detections of toxins A/B was used to identify C. difficile. A multivariate analysis was performed to evaluate potential factors associated with severe CDAD and death within 14 days after the diagnosis of CDAD, using multiple logistic regression. Sixty-six episodes were identified in 64 patients among 439 patients with diarrhea during the study period. CDA rate of incidence varied from 0.78 to 5.45 per 1,000 days of neutropenia and from 0.65 to 5.45 per 1,000 patient-days. The most common underlying disease was acute myeloid leukemia 30/64 (44%), 32/64 (46%) patients were neutropenic, 31/64 (45%) undergone allogeneic HSCT, 61/64 (88%) had previously used antibiotics and 9/64 (13%) have severe CDAD. Most of the patients (89%) received treatment with oral metronidazole and 19/64 (26%) died. The independent risk factors associated with death were the severe form of CDAD, and use of linezolid. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 56 4 325 331 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Hematology Bone marrow transplant C. difficile Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Hematology Bone marrow transplant C. difficile Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Fernanda Spadão Juliana Gerhardt Thais Guimarães Frederico Dulley João Nóbrega de Almeida Junior Marjorie Vieira Batista Maria Aparecida Shikanai-Yasuda Anna Sara Levin Silvia Figueiredo Costa INCIDENCE OF DIARRHEA BY Clostridium difficile IN HEMATOLOGIC PATIENTS AND HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: RISK FACTORS FOR SEVERE FORMS AND DEATH |
topic_facet |
Hematology Bone marrow transplant C. difficile Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
We describe the rate of incidence of Clostridium difficile-associated diarrhea (CDAD) in hematologic and patients undergone stem cell transplant (HSCT) at HC-FMUSP, from January 2007 to June 2011, using two denominators 1,000 patient and 1,000 days of neutropenia and the risk factors associated with the severe form of the disease and death. The ELISA method (Ridascreen-Biopharm, Germany) for the detections of toxins A/B was used to identify C. difficile. A multivariate analysis was performed to evaluate potential factors associated with severe CDAD and death within 14 days after the diagnosis of CDAD, using multiple logistic regression. Sixty-six episodes were identified in 64 patients among 439 patients with diarrhea during the study period. CDA rate of incidence varied from 0.78 to 5.45 per 1,000 days of neutropenia and from 0.65 to 5.45 per 1,000 patient-days. The most common underlying disease was acute myeloid leukemia 30/64 (44%), 32/64 (46%) patients were neutropenic, 31/64 (45%) undergone allogeneic HSCT, 61/64 (88%) had previously used antibiotics and 9/64 (13%) have severe CDAD. Most of the patients (89%) received treatment with oral metronidazole and 19/64 (26%) died. The independent risk factors associated with death were the severe form of CDAD, and use of linezolid. |
format |
Article in Journal/Newspaper |
author |
Fernanda Spadão Juliana Gerhardt Thais Guimarães Frederico Dulley João Nóbrega de Almeida Junior Marjorie Vieira Batista Maria Aparecida Shikanai-Yasuda Anna Sara Levin Silvia Figueiredo Costa |
author_facet |
Fernanda Spadão Juliana Gerhardt Thais Guimarães Frederico Dulley João Nóbrega de Almeida Junior Marjorie Vieira Batista Maria Aparecida Shikanai-Yasuda Anna Sara Levin Silvia Figueiredo Costa |
author_sort |
Fernanda Spadão |
title |
INCIDENCE OF DIARRHEA BY Clostridium difficile IN HEMATOLOGIC PATIENTS AND HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: RISK FACTORS FOR SEVERE FORMS AND DEATH |
title_short |
INCIDENCE OF DIARRHEA BY Clostridium difficile IN HEMATOLOGIC PATIENTS AND HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: RISK FACTORS FOR SEVERE FORMS AND DEATH |
title_full |
INCIDENCE OF DIARRHEA BY Clostridium difficile IN HEMATOLOGIC PATIENTS AND HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: RISK FACTORS FOR SEVERE FORMS AND DEATH |
title_fullStr |
INCIDENCE OF DIARRHEA BY Clostridium difficile IN HEMATOLOGIC PATIENTS AND HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: RISK FACTORS FOR SEVERE FORMS AND DEATH |
title_full_unstemmed |
INCIDENCE OF DIARRHEA BY Clostridium difficile IN HEMATOLOGIC PATIENTS AND HEMATOPOIETIC STEM CELL TRANSPLANTATION PATIENTS: RISK FACTORS FOR SEVERE FORMS AND DEATH |
title_sort |
incidence of diarrhea by clostridium difficile in hematologic patients and hematopoietic stem cell transplantation patients: risk factors for severe forms and death |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2014 |
url |
https://doi.org/10.1590/S0036-46652014000400010 https://doaj.org/article/da533983ab004ce0b7dd9a909eadfda5 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 56, Iss 4, Pp 325-331 (2014) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652014000400325&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/S0036-46652014000400010 https://doaj.org/article/da533983ab004ce0b7dd9a909eadfda5 |
op_doi |
https://doi.org/10.1590/S0036-46652014000400010 |
container_title |
Revista do Instituto de Medicina Tropical de São Paulo |
container_volume |
56 |
container_issue |
4 |
container_start_page |
325 |
op_container_end_page |
331 |
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1809896315737341952 |