Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp.
The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G ( 1 ), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine...
Published in: | Marine Drugs |
---|---|
Main Authors: | , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
MDPI AG
2019
|
Subjects: | |
Online Access: | https://doi.org/10.3390/md17020114 https://doaj.org/article/da47d8869db64a3ab189db3cde0536b4 |
id |
ftdoajarticles:oai:doaj.org/article:da47d8869db64a3ab189db3cde0536b4 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:da47d8869db64a3ab189db3cde0536b4 2023-05-15T17:41:28+02:00 Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. Alfredo F. Braña Aida Sarmiento-Vizcaíno Ignacio Pérez-Victoria Jesús Martín Luis Otero Juan José Palacios-Gutiérrez Jonathan Fernández Yamina Mohamedi Tania Fontanil Marina Salmón Santiago Cal Fernando Reyes Luis A. García Gloria Blanco 2019-02-01T00:00:00Z https://doi.org/10.3390/md17020114 https://doaj.org/article/da47d8869db64a3ab189db3cde0536b4 EN eng MDPI AG https://www.mdpi.com/1660-3397/17/2/114 https://doaj.org/toc/1660-3397 1660-3397 doi:10.3390/md17020114 https://doaj.org/article/da47d8869db64a3ab189db3cde0536b4 Marine Drugs, Vol 17, Iss 2, p 114 (2019) desertomycin macrolide Streptomyces seaweed associated actinobacteria actinomycetes intertidal seaweed Biology (General) QH301-705.5 article 2019 ftdoajarticles https://doi.org/10.3390/md17020114 2022-12-30T22:36:03Z The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G ( 1 ), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete Streptomyces althioticus MSM3, isolated from samples of the intertidal seaweed Ulva sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Particularly interesting is its strong antibiotic activity against Mycobacterium tuberculosis clinical isolates, resistant to antibiotics in clinical use. To the best of our knowledge, this is the first report on a member of the desertomycin family displaying such activity. Additionally, desertomycin G shows strong antibiotic activities against other relevant Gram-positive clinical pathogens such as Corynebacterium urealyticum , Staphylococcus aureus , Streptococcus pneumoniae , Streptococcus pyogenes , Enterococcus faecium , Enterococcus faecalis , and Clostridium perfringens . Desertomycin G also displays moderate antibiotic activity against relevant Gram-negative clinical pathogens such as Bacteroides fragilis , Haemophilus influenzae and Neisseria meningitidis . In addition, the compound affects viability of tumor cell lines, such as human breast adenocarcinoma (MCF-7) and colon carcinoma (DLD-1), but not normal mammary fibroblasts. Article in Journal/Newspaper Northeast Atlantic Directory of Open Access Journals: DOAJ Articles Marine Drugs 17 2 114 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
desertomycin macrolide Streptomyces seaweed associated actinobacteria actinomycetes intertidal seaweed Biology (General) QH301-705.5 |
spellingShingle |
desertomycin macrolide Streptomyces seaweed associated actinobacteria actinomycetes intertidal seaweed Biology (General) QH301-705.5 Alfredo F. Braña Aida Sarmiento-Vizcaíno Ignacio Pérez-Victoria Jesús Martín Luis Otero Juan José Palacios-Gutiérrez Jonathan Fernández Yamina Mohamedi Tania Fontanil Marina Salmón Santiago Cal Fernando Reyes Luis A. García Gloria Blanco Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
topic_facet |
desertomycin macrolide Streptomyces seaweed associated actinobacteria actinomycetes intertidal seaweed Biology (General) QH301-705.5 |
description |
The isolation and structural elucidation of a structurally new desertomycin, designated as desertomycin G ( 1 ), with strong antibiotic activity against several clinically relevant antibiotic resistant pathogens are described herein. This new natural product was obtained from cultures of the marine actinomycete Streptomyces althioticus MSM3, isolated from samples of the intertidal seaweed Ulva sp. collected in the Cantabrian Sea (Northeast Atlantic Ocean). Particularly interesting is its strong antibiotic activity against Mycobacterium tuberculosis clinical isolates, resistant to antibiotics in clinical use. To the best of our knowledge, this is the first report on a member of the desertomycin family displaying such activity. Additionally, desertomycin G shows strong antibiotic activities against other relevant Gram-positive clinical pathogens such as Corynebacterium urealyticum , Staphylococcus aureus , Streptococcus pneumoniae , Streptococcus pyogenes , Enterococcus faecium , Enterococcus faecalis , and Clostridium perfringens . Desertomycin G also displays moderate antibiotic activity against relevant Gram-negative clinical pathogens such as Bacteroides fragilis , Haemophilus influenzae and Neisseria meningitidis . In addition, the compound affects viability of tumor cell lines, such as human breast adenocarcinoma (MCF-7) and colon carcinoma (DLD-1), but not normal mammary fibroblasts. |
format |
Article in Journal/Newspaper |
author |
Alfredo F. Braña Aida Sarmiento-Vizcaíno Ignacio Pérez-Victoria Jesús Martín Luis Otero Juan José Palacios-Gutiérrez Jonathan Fernández Yamina Mohamedi Tania Fontanil Marina Salmón Santiago Cal Fernando Reyes Luis A. García Gloria Blanco |
author_facet |
Alfredo F. Braña Aida Sarmiento-Vizcaíno Ignacio Pérez-Victoria Jesús Martín Luis Otero Juan José Palacios-Gutiérrez Jonathan Fernández Yamina Mohamedi Tania Fontanil Marina Salmón Santiago Cal Fernando Reyes Luis A. García Gloria Blanco |
author_sort |
Alfredo F. Braña |
title |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_short |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_full |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_fullStr |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_full_unstemmed |
Desertomycin G, a New Antibiotic with Activity against Mycobacterium tuberculosis and Human Breast Tumor Cell Lines Produced by Streptomyces althioticus MSM3, Isolated from the Cantabrian Sea Intertidal Macroalgae Ulva sp. |
title_sort |
desertomycin g, a new antibiotic with activity against mycobacterium tuberculosis and human breast tumor cell lines produced by streptomyces althioticus msm3, isolated from the cantabrian sea intertidal macroalgae ulva sp. |
publisher |
MDPI AG |
publishDate |
2019 |
url |
https://doi.org/10.3390/md17020114 https://doaj.org/article/da47d8869db64a3ab189db3cde0536b4 |
genre |
Northeast Atlantic |
genre_facet |
Northeast Atlantic |
op_source |
Marine Drugs, Vol 17, Iss 2, p 114 (2019) |
op_relation |
https://www.mdpi.com/1660-3397/17/2/114 https://doaj.org/toc/1660-3397 1660-3397 doi:10.3390/md17020114 https://doaj.org/article/da47d8869db64a3ab189db3cde0536b4 |
op_doi |
https://doi.org/10.3390/md17020114 |
container_title |
Marine Drugs |
container_volume |
17 |
container_issue |
2 |
container_start_page |
114 |
_version_ |
1766143053059325952 |