CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues
Lumpfish (Cyclopterus lumpus), a North Atlantic “cleaner“ fish, is utilized to biocontrol salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar) farms. Lumpfish require excellent vision to scan for and eat louse on salmon skin. The lumpfish eye immune response to infectious diseases...
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ftdoajarticles:oai:doaj.org/article:da03ea836177466b9516509443ff4280 2023-05-15T15:32:35+02:00 CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues Robert L. Gendron Hélène Paradis Raahyma Ahmad Kenneth Kao Danny Boyce William V. Good Surendra Kumar Ignacio Vasquez Trung Cao Ahmed Hossain Setu Chakraborty Katherinne Valderrama Javier Santander 2020-11-01T00:00:00Z https://doi.org/10.3389/fimmu.2020.576897 https://doaj.org/article/da03ea836177466b9516509443ff4280 EN eng Frontiers Media S.A. https://www.frontiersin.org/articles/10.3389/fimmu.2020.576897/full https://doaj.org/toc/1664-3224 1664-3224 doi:10.3389/fimmu.2020.576897 https://doaj.org/article/da03ea836177466b9516509443ff4280 Frontiers in Immunology, Vol 11 (2020) lumpfish (Cyclopterus lumpus L.) eye immune response infection cluster of differentiation 10 immunoglobulin M Immunologic diseases. Allergy RC581-607 article 2020 ftdoajarticles https://doi.org/10.3389/fimmu.2020.576897 2022-12-31T15:51:24Z Lumpfish (Cyclopterus lumpus), a North Atlantic “cleaner“ fish, is utilized to biocontrol salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar) farms. Lumpfish require excellent vision to scan for and eat louse on salmon skin. The lumpfish eye immune response to infectious diseases has not been explored. We examined the ocular response to a natural parasite infection in wild lumpfish and to an experimental bacterial infection in cultured lumpfish. Cysts associated with natural myxozoan infection in the ocular scleral cartilage of wild adult lumpfish harbored cells expressing cluster of differentiation 10 (CD10) and immunoglobulin M (IgM). Experimental Vibrio anguillarum infection, which led to exophthalmos and disorganization of the retinal tissues was associated with disruption of normal CD10 expression, CD10+ cellular infiltration and IgM expression. We further describe the lumpfish CD10 orthologue and characterize the lumpfish scleral skeleton in the context of myxozoan scleral cysts. We propose that lumpfish develop an intraocular response to pathogens, exemplified herein by myxozoan and V. anguillarum infection involving novel CD10+ cells and IgM+ cells to contain and mitigate damage to eye structures. This work is the first demonstration of CD10 and IgM expressing cells in a novel ocular immune system component in response to disease in a teleost. Article in Journal/Newspaper Atlantic salmon North Atlantic Salmo salar Directory of Open Access Journals: DOAJ Articles Frontiers in Immunology 11 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
lumpfish (Cyclopterus lumpus L.) eye immune response infection cluster of differentiation 10 immunoglobulin M Immunologic diseases. Allergy RC581-607 |
spellingShingle |
lumpfish (Cyclopterus lumpus L.) eye immune response infection cluster of differentiation 10 immunoglobulin M Immunologic diseases. Allergy RC581-607 Robert L. Gendron Hélène Paradis Raahyma Ahmad Kenneth Kao Danny Boyce William V. Good Surendra Kumar Ignacio Vasquez Trung Cao Ahmed Hossain Setu Chakraborty Katherinne Valderrama Javier Santander CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues |
topic_facet |
lumpfish (Cyclopterus lumpus L.) eye immune response infection cluster of differentiation 10 immunoglobulin M Immunologic diseases. Allergy RC581-607 |
description |
Lumpfish (Cyclopterus lumpus), a North Atlantic “cleaner“ fish, is utilized to biocontrol salmon louse (Lepeophtheirus salmonis) in Atlantic salmon (Salmo salar) farms. Lumpfish require excellent vision to scan for and eat louse on salmon skin. The lumpfish eye immune response to infectious diseases has not been explored. We examined the ocular response to a natural parasite infection in wild lumpfish and to an experimental bacterial infection in cultured lumpfish. Cysts associated with natural myxozoan infection in the ocular scleral cartilage of wild adult lumpfish harbored cells expressing cluster of differentiation 10 (CD10) and immunoglobulin M (IgM). Experimental Vibrio anguillarum infection, which led to exophthalmos and disorganization of the retinal tissues was associated with disruption of normal CD10 expression, CD10+ cellular infiltration and IgM expression. We further describe the lumpfish CD10 orthologue and characterize the lumpfish scleral skeleton in the context of myxozoan scleral cysts. We propose that lumpfish develop an intraocular response to pathogens, exemplified herein by myxozoan and V. anguillarum infection involving novel CD10+ cells and IgM+ cells to contain and mitigate damage to eye structures. This work is the first demonstration of CD10 and IgM expressing cells in a novel ocular immune system component in response to disease in a teleost. |
format |
Article in Journal/Newspaper |
author |
Robert L. Gendron Hélène Paradis Raahyma Ahmad Kenneth Kao Danny Boyce William V. Good Surendra Kumar Ignacio Vasquez Trung Cao Ahmed Hossain Setu Chakraborty Katherinne Valderrama Javier Santander |
author_facet |
Robert L. Gendron Hélène Paradis Raahyma Ahmad Kenneth Kao Danny Boyce William V. Good Surendra Kumar Ignacio Vasquez Trung Cao Ahmed Hossain Setu Chakraborty Katherinne Valderrama Javier Santander |
author_sort |
Robert L. Gendron |
title |
CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues |
title_short |
CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues |
title_full |
CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues |
title_fullStr |
CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues |
title_full_unstemmed |
CD10+ Cells and IgM in Pathogen Response in Lumpfish (Cyclopterus lumpus) Eye Tissues |
title_sort |
cd10+ cells and igm in pathogen response in lumpfish (cyclopterus lumpus) eye tissues |
publisher |
Frontiers Media S.A. |
publishDate |
2020 |
url |
https://doi.org/10.3389/fimmu.2020.576897 https://doaj.org/article/da03ea836177466b9516509443ff4280 |
genre |
Atlantic salmon North Atlantic Salmo salar |
genre_facet |
Atlantic salmon North Atlantic Salmo salar |
op_source |
Frontiers in Immunology, Vol 11 (2020) |
op_relation |
https://www.frontiersin.org/articles/10.3389/fimmu.2020.576897/full https://doaj.org/toc/1664-3224 1664-3224 doi:10.3389/fimmu.2020.576897 https://doaj.org/article/da03ea836177466b9516509443ff4280 |
op_doi |
https://doi.org/10.3389/fimmu.2020.576897 |
container_title |
Frontiers in Immunology |
container_volume |
11 |
_version_ |
1766363084522258432 |