Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru.
During the last 50 years, the geographic range of the mosquito Aedes aegypti has increased dramatically, in parallel with a sharp increase in the disease burden from the viruses it transmits, including Zika, chikungunya, and dengue. There is a growing consensus that vector control is essential to pr...
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ftdoajarticles:oai:doaj.org/article:d9e131865783454789e816114381bdff 2023-05-15T15:14:11+02:00 Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. Robert C Reiner Steven T Stoddard Gonzalo M Vazquez-Prokopec Helvio Astete T Alex Perkins Moises Sihuincha Jeffrey D Stancil David L Smith Tadeuz J Kochel Eric S Halsey Uriel Kitron Amy C Morrison Thomas W Scott 2019-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007255 https://doaj.org/article/d9e131865783454789e816114381bdff EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007255 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007255 https://doaj.org/article/d9e131865783454789e816114381bdff PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007255 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007255 2022-12-31T13:12:52Z During the last 50 years, the geographic range of the mosquito Aedes aegypti has increased dramatically, in parallel with a sharp increase in the disease burden from the viruses it transmits, including Zika, chikungunya, and dengue. There is a growing consensus that vector control is essential to prevent Aedes-borne diseases, even as effective vaccines become available. What remains unclear is how effective vector control is across broad operational scales because the data and the analytical tools necessary to isolate the effect of vector-oriented interventions have not been available. We developed a statistical framework to model Ae. aegypti abundance over space and time and applied it to explore the impact of citywide vector control conducted by the Ministry of Health (MoH) in Iquitos, Peru, over a 12-year period. Citywide interventions involved multiple rounds of intradomicile insecticide space spray over large portions of urban Iquitos (up to 40% of all residences) in response to dengue outbreaks. Our model captured significant levels of spatial, temporal, and spatio-temporal variation in Ae. aegypti abundance within and between years and across the city. We estimated the shape of the relationship between the coverage of neighborhood-level vector control and reductions in female Ae. aegypti abundance; i.e., the dose-response curve. The dose-response curve, with its associated uncertainties, can be used to gauge the necessary spraying effort required to achieve a desired effect and is a critical tool currently absent from vector control programs. We found that with complete neighborhood coverage MoH intra-domicile space spray would decrease Ae. aegypti abundance on average by 67% in the treated neighborhood. Our framework can be directly translated to other interventions in other locations with geolocated mosquito abundance data. Results from our analysis can be used to inform future vector-control applications in Ae. aegypti endemic areas globally. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 5 e0007255 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Robert C Reiner Steven T Stoddard Gonzalo M Vazquez-Prokopec Helvio Astete T Alex Perkins Moises Sihuincha Jeffrey D Stancil David L Smith Tadeuz J Kochel Eric S Halsey Uriel Kitron Amy C Morrison Thomas W Scott Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
During the last 50 years, the geographic range of the mosquito Aedes aegypti has increased dramatically, in parallel with a sharp increase in the disease burden from the viruses it transmits, including Zika, chikungunya, and dengue. There is a growing consensus that vector control is essential to prevent Aedes-borne diseases, even as effective vaccines become available. What remains unclear is how effective vector control is across broad operational scales because the data and the analytical tools necessary to isolate the effect of vector-oriented interventions have not been available. We developed a statistical framework to model Ae. aegypti abundance over space and time and applied it to explore the impact of citywide vector control conducted by the Ministry of Health (MoH) in Iquitos, Peru, over a 12-year period. Citywide interventions involved multiple rounds of intradomicile insecticide space spray over large portions of urban Iquitos (up to 40% of all residences) in response to dengue outbreaks. Our model captured significant levels of spatial, temporal, and spatio-temporal variation in Ae. aegypti abundance within and between years and across the city. We estimated the shape of the relationship between the coverage of neighborhood-level vector control and reductions in female Ae. aegypti abundance; i.e., the dose-response curve. The dose-response curve, with its associated uncertainties, can be used to gauge the necessary spraying effort required to achieve a desired effect and is a critical tool currently absent from vector control programs. We found that with complete neighborhood coverage MoH intra-domicile space spray would decrease Ae. aegypti abundance on average by 67% in the treated neighborhood. Our framework can be directly translated to other interventions in other locations with geolocated mosquito abundance data. Results from our analysis can be used to inform future vector-control applications in Ae. aegypti endemic areas globally. |
format |
Article in Journal/Newspaper |
author |
Robert C Reiner Steven T Stoddard Gonzalo M Vazquez-Prokopec Helvio Astete T Alex Perkins Moises Sihuincha Jeffrey D Stancil David L Smith Tadeuz J Kochel Eric S Halsey Uriel Kitron Amy C Morrison Thomas W Scott |
author_facet |
Robert C Reiner Steven T Stoddard Gonzalo M Vazquez-Prokopec Helvio Astete T Alex Perkins Moises Sihuincha Jeffrey D Stancil David L Smith Tadeuz J Kochel Eric S Halsey Uriel Kitron Amy C Morrison Thomas W Scott |
author_sort |
Robert C Reiner |
title |
Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. |
title_short |
Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. |
title_full |
Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. |
title_fullStr |
Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. |
title_full_unstemmed |
Estimating the impact of city-wide Aedes aegypti population control: An observational study in Iquitos, Peru. |
title_sort |
estimating the impact of city-wide aedes aegypti population control: an observational study in iquitos, peru. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007255 https://doaj.org/article/d9e131865783454789e816114381bdff |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007255 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007255 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007255 https://doaj.org/article/d9e131865783454789e816114381bdff |
op_doi |
https://doi.org/10.1371/journal.pntd.0007255 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
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5 |
container_start_page |
e0007255 |
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1766344668267675648 |